Exercise interventions on health related quality of life for cancer survivors

Mishra, Shiraz I.; Aziz, Noreen M.; Scherer, Roberta W.; Baquet, Claudia R.; Berlanstein, Debra R; Geigle, Paula M

doi:10.1002/14651858.cd007566

Cited by 257 publications

(384 citation statements)

References 49 publications

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“…Our results are similar to previous studies and meta-analysis [8,36,[51][52][53][54][55][56]. However, this is a post-treatment study, which may lead to greater changes than previous studies developed during chemotherapy [57], suggesting that the best opportunity to modify PROs should be after cancer (neo) adjuvant treatments.…”

supporting

confidence: 88%

“…These impairments to physical capacity, assessed by maximum oxygen consumption (VO 2max ) [6], and changes in body composition (muscle mass loss and fat mass gain) have been related to poorer survival and higher risk of metabolic diseases [7]. It has been reported that exercise is an integrative intervention that could eliminate, prevent, or reduce these side effects [8]. However, very few patients are aware of and follow the exercise recommendations [9,10] possibly because clinical oncologists, during early treatment of breast cancer, may not place emphasis on exercise with this therapy being relegated to a low priority in the (neo) adjuvant treatments.…”

Section: Introductionmentioning

confidence: 99%

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Supervised physical exercise improves VO2max, quality of life, and health in early stage breast cancer patients: a randomized controlled trial

Casla

López-Tarruella

Jerez

et al. 2015

Breast Cancer Res Treat

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Breast cancer patients suffer impairment in cardiorespiratory fitness after treatment for primary disease, affecting patients' health and survival. The aim of this study was to evaluate the ability of a pragmatic exercise intervention to improve cardiorespiratory fitness of breast cancer patients after primary treatment. Between February 2013 and December 2014, 94 women with early stage (I-III) breast cancer, 1-36 months post-chemotherapy, and radiotherapy were randomly assigned to an intervention program (EX) combining supervised aerobic and resistance exercise (n = 44) or usual care (CON) (n = 45) for 12 weeks. Primary study endpoint was VO 2max . Secondary endpoints were muscle strength, shoulder range of motion, body composition, and quality of life (QoL). Assessments were undertaken at baseline, 12-week, and 6-month followups. Eighty-nine patients aged 29-69 years were assessed at baseline and 12 weeks. The EX group showed significant improvements in VO 2max , muscle strength, percent fat, and lean mass (p B 0.001 in all cases) and QoL compared with usual care (CON). Apart from body composition, improvements were maintained for the EX at 6-month follow-up. There were no adverse events during the testing or exercise intervention program. A combined exercise intervention produced considerable improvement in cardiorespiratory fitness, physical function, and quality of life in breast cancer patients previously treated with chemotherapy and radiation therapy. Importantly, most of these benefits were maintained 6 months after ceasing the supervised exercise intervention.

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supporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Supervised physical exercise improves VO2max, quality of life, and health in early stage breast cancer patients: a randomized controlled trial

Casla

López-Tarruella

Jerez

et al. 2015

Breast Cancer Res Treat

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“…Our study found that patients with stage IV disease who received surgery and CCRT had the worst HRQoL over time. Recent studies reported that colorectal cancer patients in stage IV were associated with a lower HRQoL (Färkkilä et al, 2013;Nuhu et al, 2013). Patients with advanced colorectal cancer often receive more aggressive cancer therapies that could have more side effects, thereby potentially having a negative impact on the perceived HRQoL.…”

Section: Discussionmentioning

confidence: 99%

Patient and Clinical Variables Account for Changes in Health-related Quality of Life and Symptom Burden as Treatment Outcomes in Colorectal Cancer: A Longitudinal Study

Hung¹,

Chien²,

Tsay³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Objective: The aim of the current study was to evaluate changes in treatment outcomes in terms of healthrelated quality of life (HRQoL) and symptom burden at zero, one, three, and six months after an initial diagnosis of colorectal cancer. The demographic and clinical characteristics that account for outcome changes in patients were investigated using a repeated measures framework. Methods and Materials: A cohort study was performed of 134 colorectal cancer patients followed from diagnosis to 6 months post-treatment in Central Taiwan. HRQoL and symptoms were assessed at diagnosis and one, three, and six months thereafter. The Functional Assessment of Cancer Therapy-Colon (FACT-C) questionnaire, VAS pain, and the Memorial Symptom Assessment Scale (MSAS) were used for data collection. A generalized estimating equation (GEE) was applied for statistical analysis. Results: The majority of the patients were male (55%) and married (91.5%). The mean age was 60.4 years (SD = 11.71). Most were diagnosed stage III and IV colorectal cancer (54.5%). All underwent surgery; some also received chemotherapy (CT) or concurrent chemoradiation therapy (CCRT). The results of the GEE showed that overall, the HRQoL, pain, and symptoms of the patients significantly improved over the treatment period. Patients with stage IV disease who had received surgery and CCRT showed the worst HRQoL. Females, patients with comorbidity, and stage IV patients had higher pain scores over time. Female and stage IV patients had more severe physical symptoms, whereas stage II and IV patients had worse psychological symptoms over time. Conclusion: The patients' HRQoL, pain, and symptoms significantly improved over the 6-month treatment period. Certain patient and clinical variables accounted for changes in treatment outcomes regarding HRQoL and symptom burden in colorectal cancer patients.

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“…Physical exercise has in general a positive impact on many biological processes such as energy expenditure, insulin resistance, inflammation and most body organs and tissues. In cancer patients, there is evidence that physical exercise contributes to reduce fatigue [1], improves quality of life [2,3] and relieves many of the adverse side-effects experienced both during and after treatment [4,5].…”

Section: Introductionmentioning

confidence: 99%

Effect of physical exercise on muscle mass and strength in cancer patients during treatment—A systematic review

Stene¹,

Helbostad²,

Balstad³

et al. 2013

Critical Reviews in Oncology/Hematology

172

105

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Exercise interventions on health related quality of life for cancer survivors

Cited by 257 publications

References 49 publications

Supervised physical exercise improves VO2max, quality of life, and health in early stage breast cancer patients: a randomized controlled trial

Supervised physical exercise improves VO2max, quality of life, and health in early stage breast cancer patients: a randomized controlled trial

Patient and Clinical Variables Account for Changes in Health-related Quality of Life and Symptom Burden as Treatment Outcomes in Colorectal Cancer: A Longitudinal Study

Effect of physical exercise on muscle mass and strength in cancer patients during treatment—A systematic review

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