Exercise Intervention for Late-Life Depression

Klil-Drori, Sivan; Klil-Drori, Adi J.; Pira, Shamira; Rej, Soham

doi:10.4088/jcp.19r12877

Cited by 39 publications

(29 citation statements)

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“…Nasstasia et al ( 53) used a structured multimodal exercise program combined with motivational interviewing (MI) as adjunctive therapy in patients aged 15-25 with major depression (MDD), resulting in a significant difference in the revised Beck Depression Inventory II (BDI-II) cognitive and affective subscales of the intervention group after treatment and improved somatic health and behavioral activation. Several studies of patients with late-life (older than 65) depression (152) have also confirmed that exercise reduced depressive symptoms.…”

Section: The Therapeutic Effect Of Exercise On Depressionmentioning

confidence: 78%

The Effects and Mechanisms of Exercise on the Treatment of Depression

Xie

Sun

et al. 2021

Front. Psychiatry

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Background: It is necessary to seek alternative therapies for depression, because side effects of medications lead to poor adherence and some patients do not achieve a clinical treatment effect. Recently the role of exercise as a low-cost and easy-to-use treatment for depression has gained attention with a number of studies showing that exercise is effective at reducing depressive symptoms and improving body functions such as cardiorespiratory system and cognitive function. Because of the heterogeneity of exercise therapy programs, there is no standardized and unified program. Few studies have summarized the specific properties of exercise programs (type, intensity, duration, and frequency) and clinical prescriptions for exercise are not mentioned in most articles.Aims: This study aimed to investigate the feasibility and efficacy of exercise therapy for patients with depression, in order to appraise the evidence and outline accepted guidelines to direct individualized treatment plans for patients with depression based on their individual situations.Methods: A systematic review of English language literature including papers published from 2010 to present in PubMed was performed. Given the feasibility of prescribing exercise therapy for patients with depression, nearly 3 years of clinical studies on the treatments of depressive symptoms with exercise were first reviewed, comparing the exercise programs utilized.Conclusions: Exercise has therapeutic effects on depression in all age groups (mostly 18–65 years old), as a single therapy, an adjuvant therapy, or a combination therapy, and the benefits of exercise therapy are comparable to traditional treatments for depression. Moderate intensity exercise is enough to reduce depressive symptoms, but higher-dose exercise is better for overall functioning. Exercise therapy has become more widely used because of its benefits to the cardiovascular system, emotional state, and systemic functions.Recommendations: Aerobic exercise/mind-body exercise (3–5 sessions per week with moderate intensity lasting for 4–16 weeks) is recommended. Individualized protocols in the form of group exercise with supervision are effective at increasing adherence to treatment.

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Section: The Therapeutic Effect Of Exercise On Depressionmentioning

confidence: 78%

The Effects and Mechanisms of Exercise on the Treatment of Depression

Xie

Sun

et al. 2021

Front. Psychiatry

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show abstract

“…Despite the adoption of a relatively homogeneous prescription approach, aerobic and strength training have been, for the most part, associated with benefits across a diverse range of populations (e.g., Bishop et al, 1999;Voisin et al, 2015;Flannery et al, 2019;Klil-Drori et al, 2020;Maestroni et al, 2020). On this evidence, it is assumed that a standardized, largely homogeneous exercise prescription that adopts a conventional approach is safe, efficacious, and therefore sufficient.…”

Section: Current Limitations Of Exercise Recommendations For Health Amentioning

confidence: 99%

Network Physiology of Exercise: Vision and Perspectives

et al. 2020

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The basic theoretical assumptions of Exercise Physiology and its research directions, strongly influenced by reductionism, may hamper the full potential of basic science investigations, and various practical applications to sports performance and exercise as medicine. The aim of this perspective and programmatic article is to: (i) revise the current paradigm of Exercise Physiology and related research on the basis of principles and empirical findings in the new emerging field of Network Physiology and Complex Systems Science; (ii) initiate a new area in Exercise and Sport Science, Network Physiology of Exercise (NPE), with focus on basic laws of interactions and principles of coordination and integration among diverse physiological systems across spatio-temporal scales (from the sub-cellular level to the entire organism), to understand how physiological states and functions emerge, and to improve the efficacy of exercise in health and sport performance; and (iii) to create a forum for developing new research methodologies applicable to the new NPE field, to infer and quantify nonlinear dynamic forms of coupling among diverse systems and establish basic principles of coordination and network organization of physiological systems. Here, we present a programmatic approach for future research directions and potential practical applications. By focusing on research efforts to improve the knowledge about nested dynamics of vertical network interactions, and particularly, the horizontal integration of key organ systems during exercise, NPE may enrich Basic Physiology and diverse fields like Exercise and Sports Physiology, Sports Medicine, Sports Rehabilitation, Sport Science or Training Science and improve the understanding of diverse exercise-related phenomena such as sports performance, fatigue, overtraining, or sport injuries.

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“…These contrasting results maybe explained by differences in the etiology of depressive symptoms and intensity of exercise, which may be interacting with one another. Moreover, the decreased HAMD by increasing level of exercise experienced in moderate duration of exercise condition, might suggest that there is bene cial effect of exercise on depressive symptoms [1] . Is it plausible that different mechanism are at work with respect to the moderate and short duration of exercise?…”

Section: Discussionmentioning

confidence: 99%

“…Depressive disorder often adversely affects psychosocial and physical functioning, including poor occupational functioning, role functioning, social functioning, physical health, as well as leads to high levels of disability [1] . According to World Health Organization (WHO) reports, the major depressive disorder will be the second leading cause of incapacitating disease by 2020 [2] .…”

Section: Introductionmentioning

confidence: 99%

The menopausal symptoms and depressive symptoms were efficacy of interaction between levels and duration of exercise in perimenopausal women:a cross- sectional study

S¹,

Zhang²,

W³

et al. 2020

Preprint

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Background Depressive disorder often adversely affects psychosocial and physical functioning. Exercise is one of the most commonly used alternatives for mood disorders and menopausal symptoms during the menopausal transition. This study aimed to investigate the interaction between levels and duration of exercise and their effects on menopausal symptoms and depressive symptoms. Methods We enrolled 512 healthy women aged 40–60 years. Exercise history, menopausal symptoms (MKS), and depressive symptoms (HAMD) were determined based on self-report. Menopausal symptoms and depressive symptoms was analyzed using a 2-way analysis of variance(ANOVA) with levels of exercise and duration of exercise as factors, respectively. Significant main effects or interactions were examined using Fisher’s Least Significant Difference (LSD) tests. Specific planned comparisons were made using Bonferroni corrections. Results There were interactions between levels and duration of exercise on the change in menopausal symptoms and depressive symptoms, respectively[ F (6,512) = 3.597, F (6,512) = 2.128, p <0.05]. Pairwise comparisons of the interaction revealed that, with moderate duration of exercise, those women who did high level of exercise had lower scores of MKS and HAMD than those who seldom exercised ( P <0.05). Short or long duration of exercise and low or high levels of exercise was not effective at reducing scores of MKS and HAMD( p >0.05). Conclusions The relationship between exercise and menopausal symptoms had a U-shaped trend. The relationship between exercise and depressive symptoms also had a U-shaped trend.

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Exercise Intervention for Late-Life Depression

Cited by 39 publications

References 0 publications

The Effects and Mechanisms of Exercise on the Treatment of Depression

The Effects and Mechanisms of Exercise on the Treatment of Depression

Network Physiology of Exercise: Vision and Perspectives

The menopausal symptoms and depressive symptoms were efficacy of interaction between levels and duration of exercise in perimenopausal women:a cross- sectional study

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