Exercise intensity, redox homeostasis and inflammation in type 2 diabetes mellitus

Mallard, Alistair R.; Hollekim-Strand, Siri Marte; Coombes, Jeff S.; Ingul, Charlotte Björk

doi:10.1016/j.jsams.2017.03.014

Cited by 28 publications

(58 citation statements)

References 27 publications

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“…However, currently, no studies have comprehensively examined the effect of HIIT on inflammatory cytokines and adipokines 34,38 for which effects have been mixed. [39][40][41][42] Therefore, the aim of this meta-analysis was to assess the impact of HIIT on inflammatory cytokine and adipokines in individuals with metabolic disorders, together with the modulatory effects of the training protocol and the participants physiological characteristics.…”

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confidence: 99%

The impact of high‐intensity interval training on inflammatory markers in metabolic disorders: A meta‐analysis

Khalafi

Symonds

2020

Scandinavian Med Sci Sports

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Chronic, low-grade systematic inflammation contributes to the pathogenesis of many metabolic disorders, 1 which are usually accompanied with excess adiposity. Adipose tissue is a large metabolic organ that regulates inflammatory responses due to the secretion of pro-and anti-inflammatory cytokines. 2 These can then contribute to the onset of insulin resistance 3-6 and cardiovascular disease (CVD). 7,8 An imbalanced ratio of pro-and anti-inflammatory cytokines/adipokines with excess fat mass 9 is prevalent with the metabolic syndrome (MS), 10 type 1 (T1D), 11 and 2 diabetes (T2D), 12 polycystic ovary syndrome (PCOS), 13,14 and non-alcoholic fatty liver disease (NAFLD). 15 Cytokines are

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confidence: 99%

The impact of high‐intensity interval training on inflammatory markers in metabolic disorders: A meta‐analysis

Khalafi

Symonds

2020

Scandinavian Med Sci Sports

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“…The fact that the selected papers for this review have found results different from the others may be associated then, according to Brun et al 26 and Krousel et al, 27 to the use of low intensity interventions, low volume or low compliance to intervention being the study of Mallard et al, 16 the only one to use training of moderate and intense intensities. These authors report that both MICT (Moderate Intensity Continuous Training) and HIIT (High Intensity Interval Training) had no effect on oxidative stress and inflammatory levels in individuals with T2DM over the 12 weeks of intervention with one year follow-up.…”

Section: Discussionmentioning

confidence: 93%

“…In the study by Mallard et al, 16 36 participants with T2DM were allocated into two groups in a randomized, HIIT (High Intensity Interval Training) or MICT (Moderate Intensity Continuous Training) group, through of a parallel design. Participants completed the first phase of 12 weeks of specific intensity physical training with a combination of supervised and home training.…”

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confidence: 99%

Physical Training on Glycemia and Oxidative Stress in Type 2 Diabetes: A Systematic Review

Oliveira

Ribeiro

Silva

et al. 2020

Rev Bras Med Esporte

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Introduction: Diabetes mellitus is accompanied by increased formation of reactive oxygen species (ROS) and decreased antioxidant capacity, leading to oxidative damage to cellular components. There is evidence to suggest that regular physical training positively changes oxidative homeostasis in the cells and tissues by lowering basal levels of oxidative damage, increasing resistance to oxidative stress. Objective: To verify the possible effects of aerobic physical training and resistance on glycemia and oxidative metabolism, and to determine whether there is any difference in outcomes resulting from different types of training in sedentary people with Type 2 Diabetes Mellitus (T2DM). Methods: A systematic review of controlled and randomized trials based on PRISMA. The databases LILACS, IBECS, Pubmed/MEDLINE, Cochrane Library, SciELO, PEDro, ScienceDirect and BIREME were searched, combining the descriptors type 2 diabetes mellitus, resistance training, aerobic exercise and oxidative stress in Portuguese, English and Spanish. The methodological quality of the papers was assessed by the PEDro scale. The data were read, analyzed, extracted and summarized. Results: Of the 1386 papers retrieved, only five met the inclusion criteria. The five selected papers, consisting of controlled and randomized clinical trials, were summarized. Conclusion: There have been many published studies reporting on exercises and diabetes. However, there is limitation when it comes to comparing their results. The variability of research methods and measurement instruments used makes it difficult to draw conclusions as to which physical training modality is most effective in reducing glycemic levels and oxidative stress in sedentary individuals with T2DM, considering that in each study analyzed in this review, the response to these variables is different. In future research, it would be important to standardize exercise modality, intensity, training time and evaluation parameters. Level of evidence I; Systematic review of RCTs (Randomized controlled trials).

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“…In our investigation, both the MCT and HIIT combined with RT regimens reduced the circulating levels of IL-6 following 1-year of exercise when compared with the control group, whereas no results were observed for the remaining in ammatory markers. The number of investigations that have analysed the impact of HIIT on the in ammatory pro le in T2DM are scarce, with only two shortterm interventions (< 12-week duration) reporting no substantial effects on IL-6, TNF-α, and CRP (16,17).…”

Section: Discussionmentioning

confidence: 99%

“…However, the same review suggested that there was no consensus on the long-term effects of HIIT, nor the effectiveness of HIIT vs. MCT on lipid pro le in individuals with T2DM, mainly owing to the inexistence of longer interventions or the reduced number of randomized control trials (RCT) analysing both protocols. As far as the in ammatory pro le goes, just two non RCTs analysed the impact of HIIT in individuals with T2DM, with both having a short duration intervention (< 12-weeks) and with the results suggesting limited impact (16,17).…”

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confidence: 99%

Impact of Combined Training with Different Exercise Intensities on Inflammatory and Lipid Markers in Type 2 Diabetes: A Secondary Analysis from a 1-Year Randomized Controlled Trial

Magalhães

Santos

Correia

et al. 2020

Preprint

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Background: Exercise is a well-accepted strategy to improve lipid and inflammatory profile in individuals with type 2 diabetes (T2DM). However, the exercise intensity having the most benefits on lipids and inflammatory markers in patients with T2DM remains unclear. We aimed to analyse the impact of a 1-year combined high-intensity interval training (HIIT) with resistance training (RT), and a moderate continuous training (MCT) with RT on inflammatory and lipid profile in individuals with T2DM.Methods: Individuals with T2DM (n=80, aged 59 years) performed a 1-year randomized controlled trial and were randomized into three groups (control, n= 27; HIIT with RT, n=25; MCT with RT, n=28). Exercise sessions were supervised with a frequency of 3 days per week. Inflammatory and lipid profiles were measured at baseline and at 1-year follow-up. Changes in inflammatory and lipid markers were assessed using generalized estimating equations. Results: After adjusting for sex, age and baseline moderate-to-vigorous physical activity (MVPA), circulating levels of Interleukin-6 (IL-6) decreased for both the MCT with RT (β=-0.70, p=0.034) and HIIT with RT (β=-0.62, p=0.049) groups, whereas, only the HIIT with RT group improved total cholesterol (β=-0.03, p=0.045) and LDL-C (β=-0.03, p=0.034), when compared to control. No effect was observed for C-reactive protein (CRP), cortisol, tumour necrosis factor-α (TNF-α), soluble form of the haptoglobin-hemoglobin receptor CD163 (sCD163), triglycerides and HDL-C in both groups (p>0.05).Conclusions: Favorable adaptations on IL-6 were observed in both the HIIT and MCT combined with RT groups following a long-term 1-year exercise intervention in individuals with T2DM. However, the HIIT with RT group improved to a greater extent the values of total cholesterol and LDL-C, when compared to the MCT with RT group. Therefore, in order to encourage exercise participation and improve inflammatory profile, either exercise protocols may be prescribed, however, HIIT with RT may have further benefits on the lipid profile.Trial registration: clinicaltrials.gov ID:NCT03144505

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Exercise intensity, redox homeostasis and inflammation in type 2 diabetes mellitus

Cited by 28 publications

References 27 publications

The impact of high‐intensity interval training on inflammatory markers in metabolic disorders: A meta‐analysis

The impact of high‐intensity interval training on inflammatory markers in metabolic disorders: A meta‐analysis

Physical Training on Glycemia and Oxidative Stress in Type 2 Diabetes: A Systematic Review

Impact of Combined Training with Different Exercise Intensities on Inflammatory and Lipid Markers in Type 2 Diabetes: A Secondary Analysis from a 1-Year Randomized Controlled Trial

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