Exercise Intensity and Antioxidant Ability

Nagasawa, Jun’ichi; Kikkawa, Koichi; Takai, Toshihide; Sakaguchi, Akira; Izumi, Namiki; Kizaki, Takako; Ohno, Hideki

doi:10.1089/rej.2009.0933

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…For many years, lactate was considered a metabolic residue (28,29). It is currently recognized for its role as a liver glucose precursor (15), an angiogenesis signal (28), an oxidative substrate in neurons (30), a memory consolidation molecule (31), and an antioxidant in human cells (32)(33)(34). Today, the well-established role of lactate as an antioxidant justifies its use as a food preservative (35).…”

Section: Discussionmentioning

confidence: 99%

Strenuous swimming raises blood non-enzymatic antioxidant capacity in rats

Godoy

Travassos

Antunes

et al. 2022

Braz J Med Biol Res

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The non-enzymatic antioxidant system protects blood components from oxidative damage and/or injury. Herein, plasma nonenzymatic antioxidant capacity after acute strenuous swimming exercise (Exe) and exercise until exhaustion (Exh) was measured in rats. The experiments were carried out in never exposed (Nex) and pre-exposed (Pex) groups. The Nex group did not undergo any previous training before the acute strenuous swimming test and the Pex group was submitted to daily swimming for 10 min in the first week and 15 min per day in the second week before testing. Plasma glucose, lactate, and pyruvate were measured and plasma total protein sulfhydryl groups (thiol), trolox equivalent antioxidant capacity (TEAC), ferric reducing ability of plasma (FRAP), and total radical-trapping antioxidant parameter (TRAP) levels were evaluated. There were marked increases in plasma lactate concentrations (

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Section: Discussionmentioning

confidence: 99%

Strenuous swimming raises blood non-enzymatic antioxidant capacity in rats

Godoy

Travassos

Antunes

et al. 2022

Braz J Med Biol Res

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“…As a result, little is known about the effects of chronic exercise on genes related to genomic integrity. There is, however, evidence to attest that chronic aerobic exercise can beneficially influence health-related markers and that these beneficial effects are further enhanced by increases in exercise intensity [ 29 , 30 , 44 , 45 ]. This evidence provides a reasonable basis for two assumptions that are supported by the current findings: (a) some beneficial effects of chronic aerobic exercise may stem from genome-based genomic protection (i.e.…”

Section: Discussionmentioning

confidence: 99%

Genomic Integrity Is Favourably Affected by High-Intensity Interval Training in an Animal Model of Early-Stage Chronic Kidney Disease

et al. 2016

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BackgroundChronic kidney disease (CKD) is an irreversible disease that diminishes length and quality of life. Emerging evidence suggests CKD progression and genomic integrity are inversely and causally related. To reduce health complications related to CKD progression, chronic aerobic exercise is often recommended. To date, appraisals of differing modes of exercise, along with postulations regarding the mechanisms responsible for observed effects, are lacking.In order to examine the ability of aerobic exercise to encourage improvements in genomic integrity, we evaluated the effects of 8 weeks of high-intensity interval training (HIIT; 85 % VO2max), low intensity training (LIT; 45–50 % VO2max), and sedentary behaviour (SED), in an animal model of early-stage CKD.MethodsTo assess genomic integrity, we examined kidney-specific messenger RNA (mRNA) expression of genes related to genomic repair and stability: Fan1, Mre11a, and telomere length as measured by T/S ratio.ResultsFollowing HIIT, mRNA expression of Fan1 was significantly up-regulated, compared to SED (p = 0.026) and T/S ratio was significantly increased, compared to SED (p < 0.001) and LIT (p = 0.002).ConclusionsOur results suggest that HIIT is superior to SED and LIT as HIIT beneficially influenced the expression of genes related to genomic integrity.

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“…Furthermore, many studies have shown an increase in thiobarbituric acid reactive substances (TBARS), which are an indicator of lipid peroxidation, in the blood and skeletal muscles 6) . Thus, it is thought that the volume of ROS generation generally increases depending on the intensity of exercise 7) .…”

Section: Generation Of Reactive Oxygen From Physical Exercisementioning

confidence: 99%

Exercise and oxidative stress in hypoxia

Nagasawa

Kizaki

Ohno

2013

JPFSM

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There is considerable indirect proof that a hypobaric-hypoxic environment increases oxidative stress, which is usually reflected by an increase in hepatic TBARS levels and a decrease in Mn-SOD levels. In a hypobaric chamber experiment designed to simulate the summit of Mt. Fuji, we detected an increase in hydroperoxide, an oxidative stress marker, although the percentage increase was lower than that observed at Mt. Fuji. This highlights the compounding effects of environmental factors (ultraviolet rays, temperature differences, etc.) and indicates the importance of conducting measurements in the field. Although the production of oxygen radicals increases with accelerated aerobic metabolism, it has been reported that oxidative stress increases even in hypoxic environments. Activation of xanthine oxidase (XO), that accompanies ischemia-reperfusion (I/R) or an increase in white blood cells, etc. are considered as potential mechanisms by which oxidative stress increases in hypoxic environments. However, these mechanisms have not been fully clarified.

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Exercise Intensity and Antioxidant Ability

Cited by 3 publications

References 11 publications

Strenuous swimming raises blood non-enzymatic antioxidant capacity in rats

Strenuous swimming raises blood non-enzymatic antioxidant capacity in rats

Genomic Integrity Is Favourably Affected by High-Intensity Interval Training in an Animal Model of Early-Stage Chronic Kidney Disease

Exercise and oxidative stress in hypoxia

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