Exercise Inhibits Epithelial Sodium Channels in Patients with Cystic Fibrosis

Hebestreit, Alexandra; Kersting, U.; Basler, Bettina; Jeschke, R; Hebestreit, Helge

doi:10.1164/ajrccm.164.3.2007168

Cited by 85 publications

(66 citation statements)

References 18 publications

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“…This results in cell injury and release of mediators, such as histamine, prostaglandins and leukotrienes, from mast cells, causing bronchial smooth muscle contraction [8]. In healthy individuals, sympathoadrenergic activation during exercise stimulates fluid secretion by activating Cl -channels such as CFTR and by decreasing fluid reabsorption from the airways [9]. However, secretion may not always match the loss of water.…”

mentioning

confidence: 99%

Exercise reduces airway sodium ion reabsorption in cystic fibrosis but not in exercise asthma

Schmitt¹,

Wiebel²,

Frese³

et al. 2010

European Respiratory Journal

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When ventilating large volumes of air during exercise, airway fluid secretion is essential for airway function. Since these are impaired in cystic fibrosis and exercise-induced asthma, it was the aim of this study to determine how exercise affects airway Na + and Cl -transport and whether changes depend on exercise intensity. Nasal potential was measured in Ringer's solution, with amiloride to block Na + transport, and in low chloride-containing isoproterenol to assess Cl -channels. Nasal potential was measured at rest and during submaximal and maximal bicycle ergometer exercise in individuals with cystic fibrosis, exercise-induced asthma and controls. At rest, nasal potential was significantly higher in cystic fibroses than in the others. Maximal exercise decreased nasal potentials in cystic fibrosis and controls but not in exercise asthma. Submaximal exercise decreased nasal potentials only in cystic fibrosis. Cl -transport was not affected.Our results indicate that nasal potentials and Na + transport were decreased by maximal exercise in healthy and cystic fibrosis, whereas submaximal exercise decreased potentials in cystic fibrosis only. Exercise did not affect nasal potentials in asthmatics. Decreased reabsorption during exercise might favour airway fluid secretion during hyperpnoea. This protective effect appears blunted in patients with exercise-induced asthma.

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mentioning

confidence: 99%

Exercise reduces airway sodium ion reabsorption in cystic fibrosis but not in exercise asthma

Schmitt¹,

Wiebel²,

Frese³

et al. 2010

European Respiratory Journal

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“…Hommerding et al [30] found no significant improvement in QoL domains after an education intervention of PA for children and adolescents with CF. Another study reported that QoL was associated with physical fitness and to a lesser extent with reported PA [28]. We can speculate that participation in PA could not directly increase QOL perception, but might improve subjects' self-esteem and consequently their adherence to exercise programs.…”

Section: Discussionmentioning

confidence: 84%

“…Hebestreit et al [28] showed that in CF subjects V'O 2 peak correlate positively with QOL. Cox et al [4] reported higher scores in QoL by adult subjects with CF who performed ≥ 30 minutes of moderate-vigorous PA daily compared to those who performed <30 minutes daily.…”

Section: Discussionmentioning

confidence: 98%

“…It is very likely that an active lifestyle is beneficial for higher exercise capacity values, however it cannot be excluded that better V'O 2 max also influences PA traducing into positive attitudes towards exercise participation [3,28]. Thus, one of the limitation recognised in this study is the limited sample size, however, in a specific cohort such as this, recruiting large number in few months can be difficult.…”

Section: Limitationsmentioning

confidence: 98%

“…In fact, assessing PA in adolescents using self-or parent-administered questionnaires has many limitations: they find it especially difficult to describe or quantify their PA levels and there is the risk for over reporting active habits. Accelerometers could provide minute-by-minute recording of PA and could therefore be used to objective quantify PA [7,28].…”

Section: Limitationsmentioning

confidence: 99%

See 2 more Smart Citations

Physical Activity Levels and Performance in Italian Adolescents with Cystic Fibrosis: A Multicenter Cross-sectional Study

Cazzarolli¹,

Tridello²,

Tartali³

et al. 2017

J Pulm Respir Med

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Physical exercise training for cystic fibrosis

Radtke

Nolan

Hebestreit

et al. 2015

Cochrane Database of Systematic Reviews

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BACKGROUND: Physical exercise training may form an important part of regular care for people with cystic fibrosis. This is an update of a previously published review. OBJECTIVES: To assess the effects of physical exercise training on exercise capacity by peak oxygen consumption, pulmonary function by forced expiratory volume in one second, health-related quality of life and further important patient-relevant outcomes in people with cystic fibrosis. SEARCH METHODS: We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register which comprises references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings.Date of the most recent search: 04 May 2017.We searched ongoing trials registers (clinicaltrials.gov and the WHO ICTRP). Date of most recent search: 10 August 2017. SELECTION CRITERIA: All randomised and quasi-randomised controlled clinical trials comparing exercise training of any type and a minimum duration of two weeks with conventional care (no training) in people with cystic fibrosis. DATA COLLECTION AND ANALYSIS: Two authors independently selected studies for inclusion, assessed methodological quality and extracted data. The quality of the evidence was assessed using the GRADE system. MAIN RESULTS: Of the 83 studies identified, 15 studies which included 487 participants, met the inclusion criteria. The numbers in each study ranged from nine up to 72 participants; two studies were in adults, seven were in children and adolescents and six studies included all age ranges. Four studies of hospitalised participants lasted less than one month and 11 studies were outpatient-based, lasting between two months and three years. The studies included participants with a wide range of disease severity and employed differing levels of supervision with a mixture of types of training. There was also wide variation in the quality of the included studies.This systematic review shows very low-to low-quality evidence from both short-and long-term studies that in people with cystic fibrosis aerobic or anaerobic physical exercise training (or a combination of both) has a positive effect on aerobic exercise capacity, pulmonary function and health-related quality of life. No study reported on mortality; two studies reported on adverse events (moderate-quality evidence); one of each study reported on pulmonary exacerbations (low-quality evidence) and diabetic control (very low-quality evidence). Although improvements were not consistent between studies and ranged from no effects to clearly positive effects, the most consistent effects of the heterogeneous exercise training modalities and durations were found for maximal aerobic exercise capacity (in four out of seven studies) with unclear effects on forced expiratory volume in one second (in two out of 11 studies) and health-related quality of life (in two out of seven studies). AUTHORS' CONCLUSIONS: Evidence about the efficacy of physical exercise training in cystic fibros...

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Exercise Inhibits Epithelial Sodium Channels in Patients with Cystic Fibrosis

Cited by 85 publications

References 18 publications

Exercise reduces airway sodium ion reabsorption in cystic fibrosis but not in exercise asthma

Exercise reduces airway sodium ion reabsorption in cystic fibrosis but not in exercise asthma

Physical Activity Levels and Performance in Italian Adolescents with Cystic Fibrosis: A Multicenter Cross-sectional Study

Physical exercise training for cystic fibrosis

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