Exercise-Induced Thrombocytosis

Dawson, A A; Ogston, D.

doi:10.1159/000208784

Cited by 57 publications

(22 citation statements)

References 7 publications

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“…At least in healthy subjects, the resultant hypercoagulable state is associated with a concomitant increase in fibrinolysis [18]. No clear-cut data are available concern ing a possible role of platelets during exercise, but alterations in platelet number and plate let in vitro aggregatability have been ob served repeatedly [11,12,15,19]. Thus, platelet behavior often appeared to differ be tween mild prolonged activity and strenuous exercise [13,14].…”

Section: Discussionmentioning

confidence: 99%

Exercise Induces in vivo Platelet Activation in Patients with Coronary Artery Disease and in Healthy Individuals

Schernthaner¹,

Mühlhauser²,

Böhm³

et al. 1983

Pathophysiol Haemos Thromb

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Recently, conflicting results have been published about a possible relationship between platelet activity and exercise-induced myocardial ischemia. The present study was performed to investigate platelet behavior during a graded symptom-limited bicycle ergometer test both in relation to the intensity of exercise and to exercise-induced myocardial ischemia. Plasma concentrations of platelet factor 4 (PF4) and β-thromboglobulin (β-TG) were measured by radioimmunoassays in 53 patients who had had acute myocardial infarction 10 weeks before the study and, for comparison, in 9 healthy individuals. In the whole group of the 53 patients there was no significant alteration in platelet-specific proteins during exercise, whereas physical activity induced a 2- to 3-fold increase in β-TG and PF4 levels in the controls. However, on differentiation of the patients as to their individual exercise performance, significant exercise-associated platelet activation was demonstrable in those who reached more than 75% of their calculated maximal working capacity, whereas no correlation was found between platelet activity and exercise-induced myocardial ischemia. Thus, the results from this study indicate that in vivo platelet activation is a physiological phenomenon which occurs when a certain degree of physical intensity is exceeded, independent of the precipitation of myocardial ischemia.

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Section: Discussionmentioning

confidence: 99%

Exercise Induces in vivo Platelet Activation in Patients with Coronary Artery Disease and in Healthy Individuals

Schernthaner¹,

Mühlhauser²,

Böhm³

et al. 1983

Pathophysiol Haemos Thromb

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show abstract

“…It pre sumably reflects an increased mobilization of platelets, although their source is uncertain. It is unlikely to be solely the spleen, since post-exer cise thrombocytosis may occur in splenectomized subjects [4]. There is some evidence that platelets may be mobilized from the lungs by adrena line infusion, but such platelets have been claimed to show an increased adhesiveness [10] and may, therefore, be of a different origin from those Warlow/O gston appearing after exercise which do not.…”

Section: Discussionmentioning

confidence: 99%

“…A number of studies have shown that short periods of exercise increase the venous platelet count [2,4,5,9,17], but it has been reported that there is no change in the count after prolonged exercise [2,14,17]. The increased platelet count following short periods of exercise is not associated with an increase in platelet adhesiveness [2,9], although after prolonged exercise platelet adhesion is reduced [2,14].…”

mentioning

confidence: 99%

Effect of Exercise on Platelet Count, Adhesion, and Aggregation

Warlow¹,

Ogston²

1974

Acta Haematol

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15 min of strenuous exercise caused a highly significant rise in the venous platelet count without altering platelet adhesion to glass. It also produced a significant increase in the rate of the second phase of ADPand adrenaline-induced aggregation, 5-HT-induced aggregation and disaggregation, and collagen-induced aggregation. These changes in platelet number and function following exercise should be taken into account when anti-platelet drugs are assessed in human subjects, and when changes in these parameters are sought in disease states.

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“…This could be a result of either a mobilization of existing extravascular pooled platelets, e.g. after vigorous exercise [6], or more commonly an accelerated platelet production due to an underlying disorder or condition, e.g. anemia, cancer and inflammation/ infection, where the platelets act as acute phase reactants [7].…”

Section: Discussionmentioning

confidence: 99%

Postoperative Thrombocytosis after Coronary Artery Bypass Grafting: A Potential Danger even after Hospital Discharge

Christenson¹,

Simonet²,

Schmuziger³

1999

Med Princ Pract

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Objective: Thrombocytosis (platelet counts >400 × 10³/mm³) following coronary artery bypass grafting has been described to occur frequently (20–30%) and to be associated with thrombotic complications postoperatively. The purpose of the present study is to establish when the peak value of platelet count occurs, and how high it is, as well as to determine the duration of thrombocytosis. Methods: Thirty consecutive patients undergoing elective coronary artery bypass grafting, who subsequently developed postoperative thrombocytosis (group 1) were considered for the study. Another 30 patients with platelet counts within normal limits postoperatively served as controls (group 2). Platelet count was monitored on a weekly basis during 5 weeks postoperatively. Patient characteristics, operation data and cardiopulmonary bypass data in group 1 did not differ from group 2 patients, except for a higher incidence of hyperlipidemia, i.e., 97% (29/30 patients) in group 1 compared to 40% (12/30) in group 2 (p < 0.001). Results: Neither deaths nor nonfatal myocardial infarctions occurred during the study period. Postoperative thrombocytosis was diagnosed on 6.1 ± 1.5 days postoperatively, and peak platelet count reached 14 ± 4.0 days postoperatively (6–21 days). The highest platelet count observed was 905,000/mm³. Platelet counts returned to normal values within 5 weeks. Three late vein graft occlusions occurred in all groups, and thus coinciding with the maximum platelet count observed. Conclusions: Postoperative thrombocytosis is a potentially dangerous complication, with an increased risk for vein graft occlusion. Postoperative thrombocytosis, when it occurs, is diagnosed around the 6th postoperative day, reaches its peak 2 weeks postoperatively and may last as long as 5 weeks. Close surveillance of patients with postoperative thrombocytosis is emphasized.

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Exercise-Induced Thrombocytosis

Cited by 57 publications

References 7 publications

Exercise Induces in vivo Platelet Activation in Patients with Coronary Artery Disease and in Healthy Individuals

Exercise Induces in vivo Platelet Activation in Patients with Coronary Artery Disease and in Healthy Individuals

Effect of Exercise on Platelet Count, Adhesion, and Aggregation

Postoperative Thrombocytosis after Coronary Artery Bypass Grafting: A Potential Danger even after Hospital Discharge

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