Exercise-induced Th17 Lymphocyte Response And Their Relationship To CVD Risk Factors In Obese, Post-menopausal Women

Cardenas, Maria A; Levitt, Michael M.; Richie, Bryan; Lu, Shaohan; Erickson, Elise; Cook, Carmen; Haynes, Jay; Kreutzer, Andreas; Mitchell, Joel B.; Phillips, Melody D.

doi:10.1249/01.mss.0000535829.23918.62

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“…This analysis was part of a larger study [20]. To examine the MAIT-cell response to acute exercise, OW were randomized into an exercise (EX) group and a non-exercise, education (ED) reference group.…”

Section: Experimental Designmentioning

confidence: 99%

Mucosal-Associated Invariant T Cell Response to Acute Exercise and Exercise Training in Older Obese Women

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(1) Background: Obesity is a major global public health concern as it is associated with many of the leading causes of preventable deaths. Exercise reduces obesity-induced inflammation; however, it is unknown how exercise training may impact mucosal associated invariant T (MAIT) cells in overweight/obese (OW) post-menopausal women. Therefore, the purpose of this study was to investigate (i) circulating MAIT-cells at rest in OW vs. Lean women, (ii) the response of MAIT-cells to a single bout of combined aerobic and resistance exercise, and (iii) the effects of 12 weeks of exercise training (EX) or educational program (ED) on the MAIT-cell response in OW. (2) Methods: OW completed an acute exercise session or sitting control, underwent 12 weeks of exercise training or received educational materials, and then repeated the exercise session/sitting control. Lean post-menopausal women provided a baseline comparison. (3) Results: OW had lower circulating MAIT-cells at rest than Lean prior to exercise training; however, after training EX displayed improved MAIT-cell frequency. Additionally, prior to training EX did not exhibit MAIT-cell mobilization/egress, however, both improved after training. (4) Conclusions: Reduced MAIT-cell frequency and ability to mobilize/egress were potentially partially rescued in EX after 12 weeks of exercise training; however, further research is needed to elucidate age or obesity-induced attenuations in MAIT-cells.

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Section: Experimental Designmentioning

confidence: 99%