Exercise‐induced release of troponin

Abstract

It is well established that regular physical activity reduces cardiovascular disease risk; however, numerous studies have demonstrated postexercise elevations in cardiac troponin (cTn), indicative of cardiac injury in apparently healthy individuals. The prevalence of these findings in different exercise settings and population groups, as well as potential underlying mechanisms and clinical significance of exercise‐induced cTn release are not yet quite determined. The present review will discuss the cTn response to exercise in light of developing cTn assays and the correlation between postexercise cTn release and cardiac function. Additionally, recent data regarding the potential link between strenuous endurance exercise and its relationship with unfavorable cardiac effects in athletes, as well as the management of patients presenting at emergency care after sport events will be briefly reviewed.

Factors Related to Cardiac Troponin T Increase after Participation in a 100 Km Ultra-Marathon

“…Bouts of intensive or long-lasting exercise (such as marathons or ultra-marathons) have been shown to increase blood levels of cardiac troponin, a known selective marker for myocardial injury and a major component of a current diagnosis of myocardial infarction [4][5][6][7]. Troponin rise after exercise is 2 of 9 usually discrete with levels returning to reference values within hours [8] and may be accompanied by an increase of natriuretic peptide levels and transient decrease of left or right ventricular systolic function without long-term consequences [9][10][11][12].…”

“…It is believed that cardiac troponin released after endurance exercise comes from the cytosolic pool and does not signify injury to contractile parts of the cardiomyocytes [4,7]. However, the exact mechanism explaining troponin rise related to physical activity remains ill-defined [4,7].…”

“…It is believed that cardiac troponin released after endurance exercise comes from the cytosolic pool and does not signify injury to contractile parts of the cardiomyocytes [4,7]. However, the exact mechanism explaining troponin rise related to physical activity remains ill-defined [4,7]. It has been previously related to athletes age and experience, exercise duration and intensity potentially influencing dehydration, inflammation or pH imbalance during the exercise [4,7].…”

“…However, the exact mechanism explaining troponin rise related to physical activity remains ill-defined [4,7]. It has been previously related to athletes age and experience, exercise duration and intensity potentially influencing dehydration, inflammation or pH imbalance during the exercise [4,7]. More detailed knowledge of the risk factors of this form of troponin increase could help in understanding the mechanism behind this phenomenon.…”

“…More detailed knowledge of the risk factors of this form of troponin increase could help in understanding the mechanism behind this phenomenon. They may also improve differential diagnosis in case of post-exercise suspicion of the coronary events in athletes [5,7].…”