Exercise‐induced protection against ventilator‐induced diaphragm atrophy is dependent upon increased diaphragmatic levels of manganese superoxide dismutase
Abstract:Mechanical ventilation (MV) is a life‐saving intervention for patients unable to sustain adequate pulmonary gas exchange on their own. Unfortunately, prolonged MV results in rapid atrophy and contractile dysfunction of the diaphragm, collectively termed ventilator‐induced diaphragm dysfunction (VIDD). Although the mechanisms responsible for VIDD remain elusive, it is established that increased mitochondrial production of reactive oxygen species is required for the development of VIDD. Notably, recent evidence … Show more
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