Exercise-induced muscle protein leakage in the rat

Amelink, G. J.; Bär, P.R.

doi:10.1016/0022-510x(86)90142-5

Cited by 91 publications

(48 citation statements)

References 13 publications

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“…To accomplish this objective, we examined pathogenic mechanism of CER-induced myotoxicity using young rats, which are reported to be more susceptible to statin-induced muscular injury than adult rats (Reijneveld et al, 1996). We used male rats because they are more sensitive to muscle damage than females (Amelink and Bär, 1986).…”

Section: Introductionmentioning

confidence: 99%

Cerivastatin induces type-I fiber-, not type-II fiber-, predominant muscular toxicity in the young male F344 rats

et al. 2011

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-3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are associated with adverse skeletal muscle toxicity, but the underlying mechanism remains unclear. To investigate the pathological mechanism of statin-induced myotoxicity, cerivastatin (20 ppm; corresponding to 2 mg/kg/day) was dietarily administered to young male F344 rats for 10 days, and time-course clinical observations, measurement of plasma creatine kinase activity, and light and electron microscopy of type I fiber-predominant skeletal muscle (soleus) or type II fiber-predominant skeletal muscles (extensor digitorum longus and tibialis anterior), were performed. Clinical symptoms including weakness of hind limbs, staggering gait and body weight loss, accompanied by marked plasma creatinine kinase elevation in rats fed cerivastatin at around Day 6 to 8. Interestingly, microscopic examination revealed that cerivastatin-induced muscle damages characterized by hypercontraction (opaque) and necrosis of the fibers were of particular abundance in the soleus muscle at Day 8, whereas these histological lesions in the extensor digitorum longus and tibialis anterior were negligible, even at Day 9. Prior to manifestation of muscle damage, swollen mitochondria and autophagic vacuoles in the soleus were observed as the earliest ultra structural changes at Day 6; then activated lysosomes, disarray of myofibril and dilated sarcoplasmic reticulum vesicles became ubiquitous at Day 8. These results demonstrate that cerivastatin induces type I fiber-predominant muscles injury, which is associated with mitochondrial damage, in young male F344 rats. Since the rat exhibiting type I fiber-targeted injury is a unique animal model for statin-induced myotoxicity, it will be useful for gaining insight into mechanisms of statin-induced myotoxicity.

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Section: Introductionmentioning

confidence: 99%

Cerivastatin induces type-I fiber-, not type-II fiber-, predominant muscular toxicity in the young male F344 rats

et al. 2011

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“…The role of the estrogen and its derivatives has also been implied in the CK levels reduction in women compared to men. Estrogen seems to protect the muscle from the injury derived from exercising 30 . In the study under consideration, both female Swiss and BALB/c mice, generally speaking, presented this difference compared with the male sex.…”

Section: Discussionmentioning

confidence: 99%

Infecção experimental pelo Trypanosoma cruzi em camundongos: influência do exercício físico versus linhagens e sexos

Soares

Franzói-de-Moraes

et al. 2012

Rev Bras Med Esporte

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Background: Chagas disease is an infection caused by Trypanosoma cruzi that affects eight million people in Latin America. One factor linked to the lifestyle that significantly interferes in the response to infection is physical exercise, depending on the kind, intensity and frequency of the activity practiced. Objective: To evaluate the influence of pre-infection chronic moderate aerobic exercise in the development of experimental infection with T. cruzi in mice of two distinct lineages from both sexes. Methods: 30-day old Swiss and BALB/c mice (male and female) were divided into four groups for each strain and sex (total 16) and named as follows: SM (Swiss males), SF (Swiss females) BM (BALB/c mice) and BF (BALB/c mice). The groups were: NT NI (untrained uninfected) T NI (trained not infected); NT I (untrained infected), TI (trained infected). The aerobic exercise pre-moderate chronic infection training was performed with one daily session for eight weeks, five times a week. The inoculum was 1,400 blood trypomastigotes of Y strain of T. cruziintraperitoneally. The peak of parasites, parasitemia total and average measurements of the serum activities of CK and CK-MB were evaluated. Results and Conclusions: The physical training promoted reduction in peak, parasitemia parasites and total average in animals infected with T. cruzi in both strains and sexes. Physical training induced reduction in serum activities of CK and CK-MB in animals infected with T. cruzi of both sexes and from the two strains, except for females in the Swiss CK activity.

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“…Physical stress and muscle damage change the membrane permeability of the muscle cells, increasing the levels of certain sarcoplasmic enzymes, such as the MM-CK from skeletal muscles, in the blood (Amelink and Bär, 1986).…”

Section: Creatine Kinase In Animal Productionmentioning

confidence: 99%

Implications of skeletal muscle creatine kinase to meat quality

Daroit¹,

Brandelli²

2008

J. Anim. Feed Sci.

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Creatine kinase (CK) is a key enzyme for the energetic metabolism of tissues with high and fl uctuating energy demands in vivo, as it is the case of the skeletal muscle tissue, which is the most important for the meat industry. This enzyme is generally utilized as an indicator of physical stress and/or muscle damage in animal production. However, CK continues to exert important functions after the slaughter, participating in the transformation of the muscles into meat. This article considers the main aspects of the post-mortem behaviour of CK in the skeletal musculature of meat animals, and the possible implications on meat quality.

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Exercise-induced muscle protein leakage in the rat

Cited by 91 publications

References 13 publications

Cerivastatin induces type-I fiber-, not type-II fiber-, predominant muscular toxicity in the young male F344 rats

Cerivastatin induces type-I fiber-, not type-II fiber-, predominant muscular toxicity in the young male F344 rats

Infecção experimental pelo Trypanosoma cruzi em camundongos: influência do exercício físico versus linhagens e sexos

Implications of skeletal muscle creatine kinase to meat quality

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