Exercise induced macroscopic haematuria: run for a diagnosis?

Ubels, F.L.; Essen, GG van; Jong, de Paul; Stegeman, Coen A.

doi:10.1093/ndt/14.8.2030

Cited by 11 publications

(10 citation statements)

References 8 publications

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“…The nutcracker syndrome, caused by the trapping of the left renal vein between the aorta and the superior mesenteric artery, which may cause the development of intrarenal or periureteric varices and post-exertional non-glomerular hematuria [8], was excluded in our patients. Having verified the rapid resolution of hematuria after exercise, according to others [1,2,6], we found no reason for further urological examinations and believed there would be no harm in the resumption of full activity. We believe that the most likely cause was an exercise-induced bladder trauma.…”

Section: Discussionsupporting

confidence: 64%

“…Until now, the cause-effect relationship between exercise and hematuria has been postulated on the basis of the personal history of the patients or inferred by studies on groups of athletes [1,2,3,4,5,6,7,8]. Our report shows that a simple test may help to establish the diagnosis in a given subject.…”

Section: Discussionmentioning

confidence: 75%

“…as well as in contact sports (boxing and football) [1,2]. It may consist of both gross and microscopic hematuria, and urinary red blood cells may be both glomerular and non-glomerular in shape [3,4,5,6]. In fact, the mechanisms responsible may be traced to different sources (hypoxic damage to the kidney, renal ischemia, bladder trauma, dehydratation, and so forth) or a combination thereof [1,2].…”

Section: Introductionmentioning

confidence: 99%

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Sport hematuria in boys: a provocative test

Polito

Andreoli

2005

Pediatr Nephrol

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Sports hematuria has been described in adult athletes. We report on two boys with gross hematuria after soccer matches. Urinalysis was negative for hematuria at the first visit. A simple test of effort provoked the phenomenon and allowed the detection of the post-renal origin of bleeding and the rapid resolution of hematuria. Such a test may be particularly helpful after the first episode, when it is problematic to postulate a cause-effect relationship between exercise and hematuria on the basis of the patients' history.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 99%

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Sport hematuria in boys: a provocative test

Polito

Andreoli

2005

Pediatr Nephrol

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“…Meanwhile, numerous research groups have confirmed this observation (Ernst et al 1988;Gehrmann 1966;Gilligan et al 1943;Hornbostel et al 1975;Siegel et al 1979;Ubels et al 1999;Yoshimura et al 1980). Top-class endurance athletes do train more than 20 h per week.…”

Section: Introductionmentioning

confidence: 89%

Haemolysis caused by alterations of α- and β-spectrin after 10 to 35 min of severe exercise

et al. 2005

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The pathophysiology of exercise related haemolysis is not thoroughly understood. We investigated whether exercise related haemolysis (1) is associated with alterations of red blood cell (RBC) membrane proteins similar to those found in inherited anaemic diseases, (2) can be induced with a non-running exercise mode, (3) is related to exercise intensity, and (4) coincides with indicators of oxidative stress. In ten triathletes [median (P25/P75-percentiles) age: 28.0 (26.3/28.5) years, height: 1.84 (1.78/1.87) m, body mass: 78.5 (74.8/80.8) kg, maximal oxygen uptake: 60.0 (57.3/64.8) ml kg(-1) min(-1)], haptoglobin, alpha- and beta-spectrin bands, malondialdehyde (MDA) and H2O2-induced chemiluminescence (H2O2-Chem) were determined immediately pre- and post-both, a 35 min low intensity and a high intensity cycling exercise [240 (218/253) vs 290 (270/300) W, P<0.05) requiring similar amounts of metabolic energy [28.3 (25.9/29.9) vs 24.9 (18.4/30.5) kJ kg(-1), P>0.05]. At high exercise intensity haptoglobin [1.10 (0.81/2.53) vs 1.01 (0.75/2.00) g l(-1)] decreased (P<0.05) whilst MDA [2.80 (2.65/3.20) vs 3.13 (2.78/3.31) nmol ml(-1)] and H2O2-Chem [29.70 (22.55/37.10) vs 37.25 (35.20/52.63) rel. U min] increased (P<0.05), coinciding with the disappearance of the spectrin bands in six out of ten gels. No corresponding changes were found at low intensity exercise. Ten to 35 min of non-running exercise in a regularly used intensity domain causes intra-vascular haemolysis associated with alterations in the RBC membrane proteins similar to those found after in vitro oxidative stress and in inherited anaemic diseases like Sphaerocytosis and Fanconi's anaemia.

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“…The prevalence of running-induced hematuria was about 20-25%. 1 According to literature, there are several estimated reasons for running-induced hematuria: footstrike hemolysis, increased glomerular permeability, renal ischemia, nutcracker syndrome, and their combination. 2 Especially, the pathogenesis of running-induced macroscopic hematuria was previously thought to be of glomerular origin.…”

Section: Introductionmentioning

confidence: 99%

Macroscopic hematuria caused by running‐induced traumatic bladder mucosal contusions

et al. 2018

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Introduction To clarify the mechanisms responsible for running‐induced asymptomatic gross hematuria. Case presentation We identified 12 patients who visited our outpatient clinic with hematuria after running as a chief complaint. In 9 of 12 patients (75%), cystoscopic findings revealed mucosal contusions at the center of the posterior wall. Our examination including cystoscopy and magnetic resonance imaging revealed that this bladder contusion development was caused by the repeated contact of the bladder posterior wall against the fixed bladder neck by vertical motion in the empty bladder lumen during running. All patients with bladder contusion were male because the bladder neck is more firmly fixed to the pelvic floor by the protruding prostate in men than women. Gross hematuria in all patients quickly resolved without treatment after running cessation. Conclusion This is the first report in which cystoscopic findings showed that running‐induced macroscopic hematuria can be frequently caused by traumatic bladder contusion.

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Exercise induced macroscopic haematuria: run for a diagnosis?

Cited by 11 publications

References 8 publications

Sport hematuria in boys: a provocative test

Sport hematuria in boys: a provocative test

Haemolysis caused by alterations of α- and β-spectrin after 10 to 35 min of severe exercise

Macroscopic hematuria caused by running‐induced traumatic bladder mucosal contusions

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