Exercise-Induced Irisin Secretion Is Independent of Age or Fitness Level and Increased Irisin May Directly Modulate Muscle Metabolism Through AMPK Activation

Huh, Joo Young; Mougios, Vassilis; Kabasakalis, Athanasios; Fatouros, Ioannis G.; Siopi, Aikaterina; Douroudos, Ioannis; Filippaios, Andreas; Panagiotou, Grigorios; Park, Kyung-Hee; Mantzoros, Christos S.

doi:10.1210/jc.2014-1437

Cited by 278 publications

(251 citation statements)

References 31 publications

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“…The secondary results of the included studies can be found in , and Irisin that was incubated within white adipocytes in vitro increased glucose and fatty acids uptake 67 . Furthermore, circulating Irisin after a maximal workload was significantly greater in individuals with higher VO 2 max than individuals with lower VO 2 max 22 .…”

Section: Results For Associations Of Irisin With Secondary Outcome Mementioning

confidence: 99%

“…Furthermore, an 8-week sprints exercise program increased PGC-1a and FNDC5 mRNA in muscle (p<0.05) in healthy adults 67 . Finally, Bostrom et al (2012) showed that in eight older participants selected from a larger group of 27 participants, chronic exercise increased FNDC5 mRNA in muscle (p<0.05) 2 .…”

Section: Reporting Of the Outcomesmentioning

confidence: 90%

“…Chronic effects of exercise Of the eleven eligible studies 2,17-20,41,63-68 that examined the link between PGC-1a with FNDC5 in muscle in response to chronic exercise, only two 17,67 showed that chronic exercise increased PGC1a and FNDC5 mRNA in muscle, while four studies 19,20,63,64 showed no effect of chronic exercise on PGC-1a and FNDC5 mRNA in muscle. In the five studies that only measured FNDC5 in muscle, one study 2 found increased and four 18,41,65,66 showed no effect of chronic exercise on FNDC5 mRNA in muscle.…”

Section: Reporting Of the Outcomesmentioning

confidence: 99%

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Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review

et al. 2017

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Exercise may activate a brown adipose-like phenotype in white Background: adipose tissue. The aim of this systematic review was to identify the effects of physical activity on the link between peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1a) and fibronectin type III domain-containing protein 5 (FNDC5) in muscle, circulating Irisin and uncoupling protein one (UCP1) of white adipocytes in humans. Two Methods: databases (PubMed 1966 to 08/2016 and EMBASE 1974 to 08/2016 were searched using an appropriate algorithm. We included articles that examined physical activity and/or exercise in humans that met the following criteria: a) PGC-1a in conjunction with FNDC5 measurements, and b) FNDC5 and/or circulating Irisin and/or UCP1 levels in white adipocytes. We included Results: 51 studies (12 randomised controlled trials) with 2474 participants. Out of the 51 studies, 16 examined PGC-1a and FNDC5 in response to exercise, and only four found increases in both PGC-1a and FNDC5 mRNA and one showed increased FNDC5 mRNA. In total, 22 out of 45 studies that examined circulating Irisin in response to exercise showed increased concentrations when ELISA techniques were used; two studies also revealed increased Irisin levels measured via mass spectrometry. Three studies showed a positive association of circulating Irisin with physical activity levels. One study found no exercise effects on UCP1 mRNA in white adipocytes.The Conclusions: effects of physical activity on the link between PGC-1a, FNDC5 mRNA in muscle and UCP1 in white human adipocytes has attracted little scientific attention. Current methods for Irisin identification lack precision and, therefore, the existing evidence does not allow for conclusions to be made regarding Irisin responses to physical activity. We found a contrast between standardised review methods and accuracy of the measurements used. This should be considered in future systematic reviews.

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Section: Results For Associations Of Irisin With Secondary Outcome Mementioning

confidence: 99%

Section: Reporting Of the Outcomesmentioning

confidence: 90%

Section: Reporting Of the Outcomesmentioning

confidence: 99%

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Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review

et al. 2017

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“…Another possible mechanism for statin-induced myopathy during exercise might be the down-regulation of atrogin-1 gene expression, a critical component of the ubiquitin proteasome pathway and of muscle protein catabolism [83]. Inflammation, exercise-induced irisin secretion, a myokine modulating the impact of exercise on adipocyte browning, reduced sarcolemmal or endoplasmic reticulum cholesterol, depletion of intracellular cholesterol leading to increased calcium influx, increased myocellular concentrations of cholesterol and plant sterols, modified signal transduction and metabolism due to decreased mevalonic acid and its metabolite concentrations as well as vitamin D deficiency or coenzyme Q10 deficiency might also increase the probability of statin therapy influence on the capacity of skeletal muscle to conform to the stress of exercise training [84,85].…”

Section: Physical Activity and Statin Intolerancementioning

confidence: 99%

Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel

Banach

Rizzo²,

Tóth

et al. 2015

Expert Opinion on Drug Safety

179

203

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“…These benefits occur in part because skeletal muscle is an endocrine organ and exercise stimulates skeletal muscle to produce and release myokines, which have endocrine functions [15]. Irisin is a remarkable myokine and its concentration seems to increase in response to both endurance training and RT [16][17][18][19][20]. During physical exercise, the release of this moykine is induced by the activation of PPARγ co-activator 1 alpha (PGC1-α), which stimulates the fibronectin type III domain containing 5 (FNDC5) to cleave and release irisin into the blood [16].…”

Section: Introductionmentioning

confidence: 99%

Irisin Signaling Pathway is up Regulated by Resistance Training in Ovariectomized Rats

Ns¹,

Mr²,

Lm³

et al. 2017

OCTOA

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Exercise is known to increase the concentrations of irisin, a remarkable myokine that may play an important protective role against metabolic disorders.Propose: This study investigated the effects of irisin signaling pathway induced by Resistance Training (RT) in ovariectomized (Ovx) rats.Methods: Thirty-two Holztman rats were randomly distributed to four experimental groups: Sham-Sedentary (Sed); Ovx-Sed; Sham-RT and Ovx-RT. The RT protocol demanded from the animals a vertical climb. Each session consisted of 4 to 12 climbs with 2 min. of rest during 12 weeks. To quantify mRNA expression the ∆∆Ct method was applied, protein expression was verified by Western Blotting and the analysis of irisin was determined by ELISA. When group averages were different (p ≤ 0.05), a Tukey post-hoc test was applied. Results:The Ovx-RT group had higher expression of PGC1α FNDC5, irisin levels, and UCP1 compared to Ovx-Sed. Conclusion:RT was led to higher expression of the irisin signaling pathway in the Ovx group showing that the RT seems to be an excellent strategy to counteract the ovariectomy-induced metabolic disorders.

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Exercise-Induced Irisin Secretion Is Independent of Age or Fitness Level and Increased Irisin May Directly Modulate Muscle Metabolism Through AMPK Activation

Abstract: Despite the differences in basal irisin levels, exercise-induced irisin secretion is independent of age or fitness level. Increased irisin can directly modulate muscle metabolism through AMP kinase activation.

Cited by 278 publications

References 31 publications

Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review

Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review

Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel

Irisin Signaling Pathway is up Regulated by Resistance Training in Ovariectomized Rats

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