Exercise-induced hypoxemia and cardiac arrhythmia in cystic fibrosis

Ruf, Katharina; Hebestreit, Helge

doi:10.1016/j.jcf.2008.09.008

Cited by 33 publications

(42 citation statements)

References 27 publications

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“…3 CPET is thus recommended to identify exercise-induced hypoxemia. 1 Detecting exerciseinduced oxygen desaturation and particularly patients with a drop of S pO 2 to Ͻ90% is of clinical importance because it should guide the treatment for hypoxemia (ie, supplemental oxygen).…”

Section: Discussionmentioning

confidence: 99%

“…Exercise testing is needed to detect physical limitation, the associated underlying factors, and potential adverse effects of exercise. 1,3 It is also used to set the intensity of exercise in training programs on an individualized basis. 1 Importantly, exercise testing has a strong prognostic value in CF, 4 and reduced aerobic exercise capacity has been cross-sectionally and longitudinally associated with reduced health-related quality of life (HRQOL).…”

Section: Introductionmentioning

confidence: 99%

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The 1-Minute Sit-to-Stand Test in Adults With Cystic Fibrosis: Correlations With Cardiopulmonary Exercise Test, 6-Minute Walk Test, and Quadriceps Strength

Gruet¹,

Peyré‐Tartaruga²,

Mély³

et al. 2016

Respir Care

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BACKGROUND: Exercise testing is part of the regular assessment of patients with cystic fibrosis (CF). We aimed to evaluate (1) the convergent validity of the 1-min sit-to-stand (STS) test in CF by investigating its relationships with peak oxygen uptake (peak V O 2 ), quadriceps strength, and quality of life and (2) to compare these associations with those of the 6-min walk test (6MWT). METHODS: Twenty-five adults with CF (FEV 1 ‫؍‬ 59 ؎ 24%) performed the STS test, the 6MWT, quadriceps strength assessment, and cardiopulmonary exercise test (CPET). Physical activity level, quality of life, and self-esteem were assessed by questionnaires. RESULTS: STS repetitions, 6-min walk distance, quadriceps strength, and peak V O 2 were, respectively, 71 ؎ 12, 90 ؎ 10, 93 ؎ 29, and 62 ؎ 16% of predicted. The STS test had moderate associations with peak V O 2 (r ‫؍‬ 0.56, P ‫؍‬ .004), quadriceps strength (r ‫؍‬ 0.52, P ‫؍‬ .008), and some questionnaire items (eg, perceived physical strength, r ‫؍‬ 0.67, P < .001) only when repetitions were expressed as a product of body weight. Overall, these associations were weaker than those obtained from 6-min walk distance ؋ weight. Oxygen desaturation during the STS test was strongly associated with oxygen desaturation during CPET (r ‫؍‬ 0.80, P < .001). Peak heart rate was lower during the STS test as compared with CPET (P < .001) and the 6MWT (P ‫؍‬ .009). CONCLUSIONS: The STS test cannot be used as a replacement for CPET to accurately assess peak exercise capacity in CF. The STS test may have utility in detecting patients with CF who may exhibit a high level of oxygen desaturation during heavy exercise. Further studies should identify the factors contributing to STS performance to confirm the potential interest of STS repetitions ؋ body weight outcome as a useful submaximal exercise parameter in CF.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The 1-Minute Sit-to-Stand Test in Adults With Cystic Fibrosis: Correlations With Cardiopulmonary Exercise Test, 6-Minute Walk Test, and Quadriceps Strength

Gruet¹,

Peyré‐Tartaruga²,

Mély³

et al. 2016

Respir Care

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“…The lasting effects of a 6-month home-based conditioning programme are of major clinical importance since such a programme can be realised relatively easily. The practical implementation of such a programme requires the assessment of exercise-related risks based on the patient's medical status, his or her preferred physical activities and, in some patients, the results of an exercise test to rule out exercise-induced hypoxaemia or arrhythmia [26,27]. With respect to beneficial effects, the type of activity chosen by the patient for his or her exercise routine probably does not matter.…”

Section: Discussionmentioning

confidence: 99%

Long-term effects of a partially supervised conditioning programme in cystic fibrosis

Hebestreit¹,

Kieser²,

Junge³

et al. 2009

European Respiratory Journal

126

183

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Little is known about the long-term persistence of positive effects induced by a physical conditioning programme in cystic fibrosis. Therefore, this study determined the effects of a 6-month conditioning programme on peak oxygen uptake (primary outcome) and other markers of fitness, physical activity, anthropometry, lung function and quality of life (secondary outcomes), 18 and 24 months after the programme was initiated.Patients with cystic fibrosis aged 12-40 yrs were randomly assigned to an intervention (n523) and a control (n515) group. The intervention group consented to add 3 h of sports per week for o6 months to their previous activities. Controls were asked to maintain their level of activity for 12 months. Patients were seen at baseline and after 3, 6, 12, 18 and 24 months.There was no significant difference between groups at baseline. The intervention induced positive effects on peak oxygen uptake (difference in changes from baseline to the 18-and 24-month assessments between groups: 3.72¡1. ; p,0.05), forced vital capacity (6.06¡2.87% predicted; p,0.05) and perceived health (9.89¡4.72; p,0.05).A home-based partially supervised physical conditioning programme can improve physical fitness, lung function and perceived health long after the intervention has ended.

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“…Baseline spirometric features were similar in the two groups with and without EIVA. However, Ruf and Hebestreit (24) demonstrated the occurrence of EIVA related to lower baseline oxygen saturation and at the peak exercise and FEV1 < 50% of the value predicted for patients with cystic fibrosis. These conflicting data in the literature are possibly related to different populations analyzed and, in this study, we excluded patients with heart failure, respiratory failure, renal failure and smokers.…”

Section: Discussionmentioning

confidence: 96%

Exercise-induced ventricular arrhythmias: analysis of predictive factors in a population with sleep disorders

Cintra

Makdisse

Oliveira

et al. 2010

Einstein (São Paulo)

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Objective: To assess the prevalence of ventricular arrhythmias induced by exercise in a population with sleep disorders and to analyze the triggering factors. Methods: Patients were consecutively selected from the database of the Sleep Clinic of Universidade Federal de São Paulo. All subjects were submitted to basal polysomnography, blood sample collection, physical examination, 12-lead ECG, spirometry, cardiorespiratory exercise study on a treadmill, and echocardiogram. The Control Group was matched for age and gender. results: A total of 312 patients were analyzed. Exercise-induced ventricular arrhythmia was observed in 7%. The aortic diameter was larger (3.44 ± 0.30, 3.16 ± 0.36, p = 0.04) and the minimal saturation was lower (92.75 ± 3.05, 95.50 ± 1.73, p=0.01) in the ventricular arrhythmia group when compared to controls, respectively. After correction of the aortic root to body surface, there was only a trend to a larger diameter being associated with the emergence of arrhythmia. conclusions: Exercise-induced ventricular arrhythmia was observed in 7% of sample and it was associated with lower oxygen saturation during exercise. (92.75 ± 3.05, 95.50 ± 1.73, p = 0.01) no grupo com arritmia quando comparado ao controle, respectivamente. Após correção do diâmetro de raiz da aorta para a superfície corpórea, houve apenas tendência de associação entre maior diâmetro e aparecimento de arritmia. conclusões: O aparecimento de arritmia ventricular induzida pelo esforço foi observado em 7% da amostra e associado à menor saturação de oxigênio durante o exercício. Houve tendência de maior diâmetro da raiz de aorta nesse grupo. Keywords

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Exercise-induced hypoxemia and cardiac arrhythmia in cystic fibrosis

Abstract: In order to detect all patients with exercise-induced hypoxemia and cardiac arrhythmia, an incremental exercise test to volitional fatigue must be performed.

Cited by 33 publications

References 27 publications

The 1-Minute Sit-to-Stand Test in Adults With Cystic Fibrosis: Correlations With Cardiopulmonary Exercise Test, 6-Minute Walk Test, and Quadriceps Strength

The 1-Minute Sit-to-Stand Test in Adults With Cystic Fibrosis: Correlations With Cardiopulmonary Exercise Test, 6-Minute Walk Test, and Quadriceps Strength

Long-term effects of a partially supervised conditioning programme in cystic fibrosis

Exercise-induced ventricular arrhythmias: analysis of predictive factors in a population with sleep disorders

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