Exercise-induced changes of left ventricular diastolic function in postmenopausal amateur marathon runners: assessment by echocardiography and cardiac biomarkers

Knebel, Fabian; Spethmann, Sebastian; Schattke, Sebastian; Dreger, Henryk; Schroeckh, Sabrina; Schimke, Ingolf; Hättasch, Robert; Makauskiene, Rita; Kleczka, Josephine; Sanad, Wasiem; Lock, Jürgen; Brechtel, Lars; Baumann, Gert; Borges, Adrian C.

doi:10.1177/2047487312462799

Cited by 22 publications

(23 citation statements)

References 30 publications

(31 reference statements)

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“…Moreover, we demonstrated a small increase in other parameters of LV systolic function (i.e. LV strain and SmLV) as previously described [22]. Therefore, we found no evidence of an overall decline in LV function after exercise.…”

Section: Discussionsupporting

confidence: 54%

Impact of prolonged walking exercise on cardiac structure and function in cardiac patients versus healthy controls

Benda¹,

Hopman²,

Dijk³

et al. 2016

Eur J Prev Cardiolog

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Section: Discussionsupporting

confidence: 54%

Impact of prolonged walking exercise on cardiac structure and function in cardiac patients versus healthy controls

Benda¹,

Hopman²,

Dijk³

et al. 2016

Eur J Prev Cardiolog

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“…Exercises that are appropriate and specific at the rhythm can provide better production and functioning of the testosterone hormone secreted by the body. On the contrary, it is stated that overdose cardio exercise may decrease the testosterone level (12,18). When testosterone supplementation is taken with the level of tetstosterone increased by exercise, it causes more harm than good in the body (16).…”

Section: Discussionmentioning

confidence: 99%

Investigating the Effect of Testosterone Supplement on Heart and Muscle Damage in Rats Applied with Swimming Exercise

Kulaksiz

Lök²

2019

Turkish Journal of Sport and Exercise

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Anabolic Androgenic Steroids which are a synthetic derivative of testosterone are known to be used by some sportsmen in order to improve performance. The present study was conducted to investigate the effect of testosterone supplement on heart and muscle damage in rats applied with swimming exercise. The study was conducted on 30 day-old 27 (Wistar, male) rats that were supplied from "Selçuk University Experimental Medicine Research and Application Center". The rats were divided into 4 groups. The rats in control groups (n:6) were fed during the study without doing any application. The rats in testosteronegroup (n:7) were supplied with a 10 mg/kg dose of testosterone 5 days a week for 3 weeks. The rats in exercise group (n:7) did freestyle swimming exercise for 30 minutes a day for 5 days a weekfor 3 weeks. The rats in testosterone + exercise group (n:7) did freestyle swimming exercise for 30 minutes and were administered with 10 mg/kg dose of testosterone supplement for 5 days a week for 3 weeks. At the end of the trial, necessary biochemical parameters were measured in serums obtained by drawing blood from tails of the rats. While levels of Serum, LDH, CK-MB, and CKwere studied by using an autoanalyzer, Troponin I level was analyzed by using ELISA kit. SPSS 15.0 packaged software was usedin statistical evaluation of the data and the results were given as mean±SE. Since the data were convenient with the normal distribution, ANOVA test was applied for betweengroups comparison and Duncan test was used to identify from which group the difference was resulted. When between-groups values of troponin I, ck-MB, and LDH, which are indicators of heart damage, and enzyme CK, which is an indicator of muscle damage,for control, exercise, testosterone, and testosterone+exercise groups were compared, a statistically significant difference was determined between control, exercise, testosterone, and testosterone+exercise groups (p<0.05). As a result of statistically analysis performed on all groups, the difference was found to be caused by testosterone and testosterone+exercise groups. Because testosterone production is naturally increased in the body during the exercise, swimming exercise and testosterone administration led to significant occurrence of troponin I, ck-MB, LDH, which are heart damage indicators in rats, and CK value, which is an indicator of muscle damage, in the blood.

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“…The remaining 21 accepted the invitation. The patients were asked to avoid physical exercise the day before the examination because earlier studies have shown that physical exercise or hard physical training can cause increased hs-cTnT levels [13]. Follow-up was performed at the PHC centre where the patient had chosen to be listed.…”

Section: Methodsmentioning

confidence: 99%

Consequences of high-sensitivity troponin T testing applied in a primary care population with chest pain compared with a commercially available point-of-care troponin T analysis: an observational prospective study

et al. 2015

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BackgroundThere is a demand for a highly sensitive and specific point-of care test to detect acute myocardial infarction (AMI). It is unclear if a high-sensitivity troponin assay will have enough discriminative power to become a decision support in primary care. The aim of this study was to evaluate a high-sensitivity troponin T assay performed in three primary health care centres in southeast Sweden and to compare the outcome with a point-of-care troponin T test.MethodsThis study included 115 patients who consulted their general practitioner for chest pain, dyspnoea on exertion, unexplained weakness and/or fatigue in the last 7 days. Troponin T was analysed by a point-of-care test and a high-sensitivity method together with N-terminal pro-B-type natriuretic peptide (NT-proBNP) and creatinine. All patients were checked for AMI or unstable angina (UA) within 30 days of study enrolment. Univariate and multivariate logistic regression was carried out to examine possible connections between troponin T ≥ 15 ng/L, clinical variables and laboratory findings at baseline. In addition, 21 patients with troponin T ≥ 15 ng/L and no signs of AMI or UA were followed up for 2–3 years.ResultsThree patients were diagnosed with AMI and three with UA. At the ≥ 15 ng/L cut-off, the troponin T method had 100% sensitivity, 75% specificity for AMI and a positive predictive value of 10%. The troponin T point-of-care test missed one case of AMI and the detection limit was 50 ng/L. Troponin T ≥ 15 ng/L was correlated to age ≥65 years (odds ratio (OR), 10.9 95% CI 2.28–51.8) and NT-proBNP in accordance with heart failure (OR 8.62 95% CI 1.61–46.1). Fourteen of the 21 patients, without signs of AMI or UA at baseline, still had increased troponin T at follow-up after 2–3 years.ConclusionsA high-sensitivity troponin T assay could become useful in primary care as a point-of-care test for patients <65 years. For patients older than 65–70 years, a higher decision limit than ≥15 ng/L should be considered and used in conjunction with clinical parameters and possibly with NT-proBNP.

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Exercise-induced changes of left ventricular diastolic function in postmenopausal amateur marathon runners: assessment by echocardiography and cardiac biomarkers

Abstract: 2D strain analysis of the left and right ventricles showed an acute improvement of the systolic function after marathon running in pre- and postmenopausal well-trained women. There were no long lasting detrimental effects on the diastolic function.

Cited by 22 publications

References 30 publications

Impact of prolonged walking exercise on cardiac structure and function in cardiac patients versus healthy controls

Impact of prolonged walking exercise on cardiac structure and function in cardiac patients versus healthy controls

Investigating the Effect of Testosterone Supplement on Heart and Muscle Damage in Rats Applied with Swimming Exercise

Consequences of high-sensitivity troponin T testing applied in a primary care population with chest pain compared with a commercially available point-of-care troponin T analysis: an observational prospective study

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