Exercise-induced Changes in Common Laboratory Tests

Abstract

Examination of 19 serum biochemical and hematologic parameters in a group of white male runners, ranging in age from 23 to 47 years, just prior to and immediately after a 13-mile "mini-marathon," demonstrated a significant increase, by paired Student t-test, in mean values of: K+, BUN, creatinine, CK, LDH, AST (SGOT), alkaline phosphatase, bilirubin, uric acid and leukocyte counts. Prevailing environmental conditions were such as to produce no significant hemoconcentration. Using this group's statistics and this hospital laboratory's upper limits of normal, the percentage of values above two SDs are, for the resting state: K+ 7%, BUN 7%, creatinine 0%, CK 21%, LDH 21%, AST 0%, alkaline phosphatase 0%, bilirubin 7%, uric acid 7%, and leukocyte count 0%. Post-exertional values above normal limits are: K+ 7%, BUN 21%, creatinine 21%, CK 93%, LDH 86%, AST 0%, alkaline phosphatase 0%, bilirubin 14%, uric acid 36%, and leukocyte 71%. Consequently, abnormally high values for K+, BUN, creatinine, CK, LDH, bilirubin, uric acid, and leukocyte counts can often be expected in some patients who exercise heavily. The degree of the abnormality will depend on the level and length of exercise as well as the elapsed time between exercise and testing.

Inflammatory and Biochemical Biomarkers in Response to High Intensity Resistance Training in Trained and Untrained Men

“…CK and LDH isoenzymes are muscle injury biomarkers (25). Some studies have shown changes in muscle enzymes and isoenzymes serum concentrations after intense training in athletes and untrained subjects (26,27). Increased CK activity may be due to metabolic and mechanical causes.…”

Influence of Acqua Lete® (Bicarbonate Calcic Natural Mineral Water) Hydration on Blood Lactate After Exercise

“…The evaluation of total LDH and its isoenzymes allows obtaining much information about the muscle metabolism [4]. In fact strenuous exercise induces a significant increase of LDH [31] and the degree of the rise depends on the intensity and duration of the effort [32,33]. We did not found an increase of total enzyme in Group A, neither in Group B, in both tests (C and H), probably for the type and intensity of effort: In our study the time of examination (30 minutes after exercise) and the type of exercise (submaximal) did not allow to detect a significant increase of total enzyme (Tables 3 and 4).…”

Monitorización de biomarcadores sanguíneos en jugadores profesionales de fútbol durante la fase preparatoria y competitiva. [Monitoring biochemical markers in professional soccer players during the season and preseason preparation phase].

“…El límite sobre el nivel de intensidad por el cual el musculo puede soportar es el punto de equilibrio: cuando la carga excede un cierto límite, la creatina quinasa (CK) y otras enzimas proteicas como la lactato de hidrogenasa (LDH), se liberan hacia el fluido intersticial y son absorbidas a través del sistema linfático, retornando de esta manera al flujo sanguíneo (Bijsterbosch y col., 1985). La LDH es inducida por el ejercicio, y el grado de su incremento dependerá de la intensidad y la duración del esfuerzo (Priest, Oei, Moorehead, 1982;Munjal, McFadden, Matix, Coffman, Cattaneo, 1983;Stokke, 1982). Se ha observado un importante incremento de LDH entre el L Vilamitjana, J.; Vaccari, J. C.; Toedtli, M.; Navone, D.; Rodríguez-Buteler, J. M.; Verde, P. E., y CallejaGonzález, J.…”