Exercise-induced bronchoconstriction in athletes – A qualitative assessment of symptom perception

Diagnosing exercise‐induced bronchoconstriction: Over‐or under‐detection?

“…Consistent with our previous Western blot data, 3 immunostaining analysis revealed high LAT1 expression in anti-CD3/CD28 antibody (Ab)-stimulated, but not unstimulated, human peripheral CD4 + T cells ( Figure 1A). Since atopic dermatitis (AD) is accompanied by T-cell activation, 5 we assumed that LAT1 is expressed in T cells at the lesional sites of dermatitis patients. Indeed, DAB immunostaining revealed strong LAT1 expression in the skin with AD, which partly overlapped with the CD4 expression area ( Figure 1B).…”

The Allergy Questionnaire for Athletes provides value in ruling‐out exercise‐induced bronchoconstriction

“…This finding supports the concept that AQUA and/or self-report respiratory symptoms should not be used to confirm a diagnosis in the absence of indirect bronchoprovocation testing. 2 Importantly, however, for the first time, our data indicate that a negative AQUA score (<5) offers excellent diagnostic sensitivity (ie, ability to rule-out EIB).…”

“…To the Editor, Exercise-induced bronchoconstriction (EIB) refers to a condition characterised by expiratory airflow limitation during physical activity and is one of the most common causes of exertional breathing difficulty in young athletic individuals. 1 Due to the limited value of a symptom-based approach to diagnosis, 2 it is now widely recognised that EIB should be objectively confirmed via indirect bronchoprovocation testing before initiating treatment, with eucapnic voluntary hyperpnoea (EVH) often endorsed for this purpose. 3 Although the feasibility of EVH testing is well established, the practicalities and associated cost of assessment is substantial and therefore not widely available as part of routine diagnostic work-up across primary and secondary care.…”

Anti-doping Policy, Therapeutic Use Exemption and Medication Use in Athletes with Asthma: A Narrative Review and Critical Appraisal of Current Regulations

“…over- and under-detected) in both elite and recreational athletes [ 8 , 70 ]. Despite recognition of the disconnect between self-report respiratory symptoms and objective evidence of asthma [ 71 ], a study by Hull et al found that approximately one-quarter of primary care clinicians in the UK initiate treatment based on clinical history alone [ 68 ]. Although objective testing is often requested, test selection is typically sub-optimal for the assessment of the breathless athlete (e.g.…”