Exercise-induced Biochemical Modifications in Muscle in Chronic Kidney Disease: Occult Acidosis as a Potential Factor Limiting the Anabolic Effect of Exercise

Clapp, Emma L.; Bevington, Alan

doi:10.1053/j.jrn.2010.10.023

Cited by 12 publications

(10 citation statements)

References 15 publications

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“…These results were supported by data from studies that found impaired EMG signals and impaired physical function in patients undergoing HD compared to healthy persons . Circulating phosphate has been suggested to be an important neurotoxin affecting neuromuscular function, and acidosis determined as bicarbonate may also play a role in muscle function . To control these factors the ‘baseline’ and the ‘post’ tests were conducted identically with respect to the dialysis procedures, and phosphate and bicarbonate were found to be unchanged in the present study.…”

Section: Discussionsupporting

confidence: 83%

Increased rate of force development and neuromuscular activity after high‐load resistance training in patients undergoing dialysis

et al. 2013

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Section: Discussionsupporting

confidence: 83%

Increased rate of force development and neuromuscular activity after high‐load resistance training in patients undergoing dialysis

et al. 2013

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“…Metabolic acidosis has been suggested to be associated with IR, as shown in the present study, and negatively with muscle growth [27,28]. Whilst metabolic acidosis may result in muscle atrophy, it may as well be a limiting factor in muscle growth in relation to strength training.…”

Section: Discussionsupporting

confidence: 65%

Improved Glucose Tolerance after High-Load Strength Training in Patients Undergoing Dialysis

et al. 2013

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Background/Aims: The aim of this controlled study was to investigate the effect of high-load strength training on glucose tolerance in patients undergoing dialysis. Methods: 23 patients treated by dialysis underwent a 16-week control period followed by 16 weeks of strength training three times a week. Muscle fiber size, composition and capillary density were analyzed in biopsies obtained in the vastus lateralis muscle. Glucose tolerance and the insulin response were measured by a 2-hour oral glucose tolerance test. Results: All outcome measures remained unchanged during the control period. After strength training the relative area of type 2X fibers was decreased. Muscle fiber size and capillary density remained unchanged. After the strength training, insulin concentrations were significantly lower in patients with impaired glucose tolerance or type 2 diabetes (n = 14) (fasting insulin from 68 ± 12 (46-96) to 54 ± 10 (37-77) pmol/l, p < 0.05, 2-hour insulin from 533 ± 104 (356-776) to 344 ± 68 (226-510) pmol/l, p < 0.05, total insulin area under the curve from 1,868 ± 334 (1,268-2,536) to 1,465 ± 222 (1,094-1,913), p < 0.05). Insulin concentrations were unchanged in patients with normal glucose tolerance (n = 9). Conclusion: The conducted strength training was associated with a significant improvement in glucose tolerance in patients with impaired glucose tolerance or type 2 diabetes undergoing dialysis. The effect was apparently not associated with muscle hypertrophy, whereas the muscle fiber type composition was changed.

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“…Although there are no recommendations prepared especially for children with CKD, general pediatric recommendations advise that daily physical activity should be at least 60–90 min of accepted anaerobic exercise [100]. One of the limiting factors of the anabolic effect of exercise and increase of lean body mass in CKD patients is acidosis [101]. The other limiting factor of life-style interventions in children with CKD and after Rtx is non-compliance.…”

Section: Non-pharmacological Treatment Strategiesmentioning

confidence: 99%

Metabolic syndrome in children with chronic kidney disease and after renal transplantation

Litwin

Niemirska

2013

Pediatr Nephrol

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Visceral obesity and metabolic abnormalities typical for metabolic syndrome (MS) are the new epidemic in adolescence. MS is not only the risk factor for cardiovascular disease but also for chronic kidney disease (CKD). Thus, there are some reasons to recognize MS as a new challenge for pediatric nephrologists. First, hypertensive and diabetic nephropathy, the main causes of CKD in adults, both share the same pathophysiological abnormalities associated with visceral obesity and insulin resistance and have their origins in childhood. Secondly, as the obesity epidemic also affects children with CKD, MS emerges as the risk factor for progression of CKD. Thirdly, metabolic abnormalities typical for MS may pose additional risk for cardiovascular morbidity and mortality in children with CKD. Finally, although the renal transplantation reverses uremic abnormalities it is associated with an exposure to new metabolic risk factors typical for MS and MS has been found to be the risk factor for graft loss and cardiovascular morbidity after renal transplantation. MS is the result of imbalance between dietary energy intake and expenditure inducing disproportionate fat accumulation. Thus, the best prevention and treatment of MS is physical activity and maintenance of proper relationship between lean and fat mass.

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Exercise-induced Biochemical Modifications in Muscle in Chronic Kidney Disease: Occult Acidosis as a Potential Factor Limiting the Anabolic Effect of Exercise

Cited by 12 publications

References 15 publications

Increased rate of force development and neuromuscular activity after high‐load resistance training in patients undergoing dialysis

Increased rate of force development and neuromuscular activity after high‐load resistance training in patients undergoing dialysis

Improved Glucose Tolerance after High-Load Strength Training in Patients Undergoing Dialysis

Metabolic syndrome in children with chronic kidney disease and after renal transplantation

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