“…Although intrinsic conduction tissue disease seems of paramount importance [8,10], an ischemic contribution can also be present and should be excluded [10,11,13]. Indeed, an ischemic defect affecting the atrioventricular (AV) node has been described as a possible cause of exercise-induced CAVB [10,13,14]. Besides significant epicardial CAD, arterial vasospasm has also been described a possible cause of CAVB [15].…”