Exercise-induced asthma: Update on pathophysiology, clinical diagnosis, and treatment

Randolph, Christopher

doi:10.1016/s0045-9380(97)80002-3

Cited by 38 publications

(29 citation statements)

References 153 publications

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“…Only 5% fell in the severe classification (16). Children with EIA were more likely to report that they wheezed during or after exercise and the p-value was significant (p < 0.05).…”

Section: Classification On Severity Of Eia and Percentage Scoresmentioning

confidence: 92%

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Effect of Submaximal Warm-up Exercise on Exercise-induced Asthma in African School Children

2015

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“…Only 5% fell in the severe classification (16). Children with EIA were more likely to report that they wheezed during or after exercise and the p-value was significant (p < 0.05).…”

Section: Classification On Severity Of Eia and Percentage Scoresmentioning

confidence: 92%

“…Exercise-induced asthma may also appear during sustained exertion (12,15). Exercise-induced asthma occurs in up to 90% of asthmatics and 40% of patients with allergic rhinitis; among athletes and in the general population, its prevalence is between 6% and 13% (16).…”

Section: Introductionmentioning

confidence: 99%

Effect of Submaximal Warm-up Exercise on Exercise-induced Asthma in African School Children

2015

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“…There are two prominent theories underlying the mechanism of EIB: heat loss and hyperosmolality. During and after exercise, the airway mucosa is exposed to rapid, large volumes of air which may be inadequately warmed, not fully humidifi ed, or both (Randolph 1997 ;Anderson and Daviskas 2000 ). Either heat loss or water loss (and osmotic change) is thought to trigger release of infl ammatory mediators (McFadden and Gilbert 1999 ;Anderson and Daviskas 1999 ).…”

Section: Exercise-induced Asthmamentioning

confidence: 99%

Introduction to Asthma and Phenotyping

Pillai

Calhoun

2013

Advances in Experimental Medicine and Biology

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Asthma is an inflammatory disorder characterized by airway obstruction, airway hyperresponsiveness, and airway inflammation, all of which are variable among patients and variable in time within any specific patient. Understanding the mechanism that underlies this observed variability, and using that understanding to advance the science of asthma and the care of asthmatic patients, is an essential purpose of developing phenotypes. Clinical phenotypes have been used for decades, but overlap each other, and do not map cleanly to either pathophysiologic mechanism or with therapeutic response. Molecular phenotyping, although as yet only partially developed, offers the promise of dissecting the mechanistic underpinnings of the variability of asthma and of providing predictive therapeutics for the benefit of patients with this common and troubling disease.

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“…Airway cooling and drying exerts a thermal and osmotic effect on the epithelial cells, mast cells, and the sensory nerves. This triggers the release of mediators such as histamine, prostaglandins D2 and E2, leukotrienes, and interleukins [18], which results in smooth muscle contraction. Exercise provokes bronchospasm in a majority of asthmatics.…”

Section: Exercise Challenge Testingmentioning

confidence: 99%

Bronchoprovocation Testing

Reddy

2009

Clinic Rev Allerg Immunol

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Airway smooth muscles of asthmatics tend to be hyperresponsive when provoked. The exaggerated bronchial constriction can be measured by the airflow limitation seen following bronchial provocation. Measuring bronchial hyperresponsiveness by broncho provocation testing is helpful in diagnosing and optimizing therapy. While numerous agents have been used to provoke a measurable airflow limitation, standardized protocols are available for only a few. This article aims to discuss the various methods that have been reported for bronchoprovocation testing.

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Exercise-induced asthma: Update on pathophysiology, clinical diagnosis, and treatment

Cited by 38 publications

References 153 publications

Effect of Submaximal Warm-up Exercise on Exercise-induced Asthma in African School Children

Effect of Submaximal Warm-up Exercise on Exercise-induced Asthma in African School Children

Introduction to Asthma and Phenotyping

Bronchoprovocation Testing

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