Exercise-induced anti-inflammatory effects in overweight/obese women with polycystic ovary syndrome

Dantas, Wagner Silva; Neves, Willian das; Gil, Saulo; Barcellos, Cristiano Roberto Grimaldi; Rocha, Michele Patrocínio; Sá-Pinto, Ana Lúcia de; Roschel, Hamilton; Gualano, Bruno

doi:10.1016/j.cyto.2019.04.006

Cited by 20 publications

(18 citation statements)

References 12 publications

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“…In this study, LSM was not significantly associated with changes in glucose metabolism, whereas other meta-analyses reported that LSM in adult PCOS women reduced fasting blood glucose, insulin levels and insulin resistance [15,59]. We would like to note that intensive lifestyle modification and weight reduction are necessary to reduce circulating insulin and androgen levels [46] and this conflict might be due to the fact that intensive LSM in adolescents might not be a common phenomenon. Indeed, it has been proposed that weight management with LSM interventions may be less effective in adolescent girls with PCOS.…”

Section: Discussionmentioning

confidence: 58%

“…There is evidence demonstrating that exercise is associated with significant improvements in ovarian morphology, and ovulatory cycles, mainly through decreasing plasma TNF-α, and increasing plasma IL-4 and IL-10. In addition, it is well-documented that decreased insulin concentration during intensive exercises can improve hirsutism, acne, and menstrual regularity [46].…”

Section: Discussionmentioning

confidence: 99%

“…Importantly, moderate to vigorous daily physical activity for at least 60 min is related to better physical and psychosocial health in children and adolescents [66]. Although the low-glycemic diet in PCOS is recommended [46], international guidelines have demonstrated that there is limited evidence as to which specific energy equivalent diet type is better [67]. In addition, based on the international guidelines, a duration of 6 to 12 months is the minimum time for the effects of LSM to show.…”

Section: Discussionmentioning

confidence: 99%

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Effect of lifestyle modifications on anthropometric, clinical, and biochemical parameters in adolescent girls with polycystic ovary syndrome: a systematic review and meta-analysis

et al. 2020

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Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of childbearing age. This study aimed to compare the effects of lifestyle interventions on anthropometric, clinical, and biochemical parameters in adolescent girls with PCOS. Methods: PubMed, Scopus, and Web of Science was systematically searched to retrieve studies investigating the effects of lifestyle modifications in adolescent girls with PCOS, which were published up to December 2019. The primary outcome was Body Mass Index (BMI) and secondary outcomes were all manifestations of PCOS, including clinical, metabolic, and hormonal parameters. Random effect meta-analysis was applied for significant results. Publication bias was assessed using the Egger test. Results: This study showed significant improvements in luteinizing hormone (LH) (Pooled SMD = − 0.1.23; 95% CI, − 2.44 to − 0.03), and Free Androgen Index (FAI) levels (Pooled SMD = − 0.78 95% CI, − 0.1.42 to − 0.13) in adolescent girls receiving lifestyle intervention compared to baseline. This study also revealed that diet modifications alone were associated with a significant decrease in Body Mass Index (BMI) (Pooled SMD = − 0.45; 95% CI, − 0.76 to − 0.13), and FG score (Pooled SMD = − 0.81; 95% CI, − 1.33 to − 0.28). Exercise interventions were associated with significant changes in the menstrual cycles (Pooled SMD = 1.16; 95% CI, 0.72 to 1.61), Ferriman-Gallwey (FG) score (Pooled SMD = − 0.57; 95% CI, − 0.99 to − 0.15), LH (Pooled SMD = − 056; 95% CI, − 0.98 to − 0.14), Anti-Müllerian Hormone (AMH) (Pooled SMD = − 0.81; 95% CI, − 0.1.24 to − 0.38), and Triglyceride (TG) levels (Pooled SMD = − 0.32; 95% CI, − 0.62 to − 0.02).

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effect of lifestyle modifications on anthropometric, clinical, and biochemical parameters in adolescent girls with polycystic ovary syndrome: a systematic review and meta-analysis

et al. 2020

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“…Increasing evidence has recently indicated that chronic inflammatory response plays a key role in the pathophysiology of exercise-induced fatigue (Vargas and Marino, 2014). The practice of regular, non-exhaustive physical activity improves health conditions and have beneficial effects on immunity (Dantas et al, 2019). However, excessive training with insufficient recovery causes musculoskeletal trauma with increased production of pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α, which contributes to symptoms related to performance decrement and exercise-induced fatigue (Smith, 2000, 2004; Carmichael et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Exercise can have favorable and harmful effects on the body depending on its intensity and duration. Regular and moderate exercise can have beneficial effects on immunity (Weinhold et al, 2016; Dantas et al, 2019), as well as improving LPS-induced learning and memory impairments by attenuating the hippocampal cytokine levels (Jahangiri et al, 2019). However, exhaustive exercise has been shown to reduce immune function, increase the risk of infection, and contribute to fatigue (Banfi et al, 2008; Kakanis et al, 2010; Shaw et al, 2018; Castell et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Moxibustion Reduces Inflammatory Response in the Hippocampus of a Chronic Exercise-Induced Fatigue Rat

Shui

et al. 2019

Front. Integr. Neurosci.

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Accumulating data indicates that brain inflammation plays an important role in the pathophysiology of chronic exercise-induced fatigue. Moxibustion in traditional Chinese medicine has been found to alleviate exercise-induced fatigue. However, it remains unclear whether the effect of moxibustion is related to its anti-inflammatory properties. In this study, rats were exposed to 3-week exhaustive swimming to induce chronic exercise-induced fatigue. The body weight, exhaustive swimming time, tail suspension test and open-field test were observed. Real-time polymerase chain reaction (RT-PCR) was used to determine the mRNA expression of proinflammatory cytokines (interleukin-1β [IL-1β], interleukin-6 [IL-6], and tumor necrosis factor-α[TNF-α]), and enzyme-linked immunosorbent assay (ELISA) was used to detect IL-1β, IL-6, and TNF-α concentrations. Chronic exhaustive exercise significantly reduced the body weight and exhaustive swimming time, and increased tail suspension immobility time, which were reversed by moxibustion treatment. Compared with control rats, the mRNA and protein expression of IL-1β, IL-6, and TNF-α in the hippocampus was significantly increased in exhaustive swimming trained rats. Moxibustion significantly decreased the level of IL-6 in the hippocampus, but not affected IL-1β and TNF-α level significantly. Our results suggested that a potential inflammatory damage in the brain may be involved during chronic exhaustive exercise-induced fatigue. Moxibustion could attenuate the inflammatory impairment in exercise-induced fatigue, which might be mediated by inhibition of the proinflammatory cytokine IL-6 levels in the brain region.

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Exercise and Energy Metabolism in Cancer Research

Vulczak,

Alberici

2024

Interdisciplinary Cancer Research

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Exercise-induced anti-inflammatory effects in overweight/obese women with polycystic ovary syndrome

Cited by 20 publications

References 12 publications

Effect of lifestyle modifications on anthropometric, clinical, and biochemical parameters in adolescent girls with polycystic ovary syndrome: a systematic review and meta-analysis

Effect of lifestyle modifications on anthropometric, clinical, and biochemical parameters in adolescent girls with polycystic ovary syndrome: a systematic review and meta-analysis

Moxibustion Reduces Inflammatory Response in the Hippocampus of a Chronic Exercise-Induced Fatigue Rat

Exercise and Energy Metabolism in Cancer Research

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