Exercise improves the success of myoblast transplantation in mdx mice

Intrasphincteric autologous myoblast injections with electrical stimulation for stress urinary incontinence

“…A rotating, high-frequency (15)(16)(17)(18)(19)(20), transurethral 8F ultrasound microprobe associated with an injection device (Sonoject; AMI, Feldkirch, Austria) enabled visualization of the rhabdosphincter and injection of the myoblast suspension with precision. In a relatively simple procedure the probe was gently inserted up the urethra into the bladder.…”

“…In 2006, an in vitro study reported that ES accelerated the maturation and organization of myoblasts into myotubes, that the newly produced muscle fibers were spontaneously contracting, and that these events probably accelerated the restoration of tissue function [17]. Exercise was also shown to increase long-term graft success by enhancing the recruitment and fusion of transplanted myoblasts [18]. Thus, the muscle regeneration that follows myoblast injections might be accelerated by ES as a form of physical therapy.…”

Muscle-derived cell injection to treat anal incontinence due to obstetric trauma: pilot study with 1 year follow-up

“…Because animal21 and human22 studies have shown that electrical stimulation enhances integration of myoblasts into host tissue, all 10 women underwent an anal electrical stimulation programme before implantation via an anal plug fitted with two ring electrodes. Batteries were contained within an external handset, which also turned the unit on and off and set the stimulation time and electrical frequency.…”

Exercise‐induced stem cell activation and its implication for cardiovascular and skeletal muscle regeneration

“…It has been described e.g. that transplantation of normal muscle precursor cells is a potential approach to restore dystrophin expression within dystrophin deficient mdx mice, a model of Duchenne Muscular Dystrophy (91). In the same study it was shown that exercise-induced fiber breaks, which improved muscle progenitor cells recruitment and fusion and increased long-term graft success and also transverse and longitudinal distribution of hybrid fibers (91).…”

“…that transplantation of normal muscle precursor cells is a potential approach to restore dystrophin expression within dystrophin deficient mdx mice, a model of Duchenne Muscular Dystrophy (91). In the same study it was shown that exercise-induced fiber breaks, which improved muscle progenitor cells recruitment and fusion and increased long-term graft success and also transverse and longitudinal distribution of hybrid fibers (91). In a very recent study it was demonstrated that exercise training for three weeks after acute myocardial infarction leads to a significant mobilization and increase in functional activation of bone marrow-derived circulating progenitor cells in humans (21).…”