Exercise improves the ApoB/ApoA‐I ratio, a marker of the metabolic syndrome in obese children

Ounis, Omar Ben; Elloumi, Mohamed; Makni, Emna; Amri, Mohamed; Tabka, Zouhaïr; Lac, G.

doi:10.1111/j.1651-2227.2010.01920.x

Cited by 47 publications

(88 citation statements)

References 25 publications

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“…The main content of the programs was based on treadmills, cycle ergometers, rowers (machines) (23,28), sports games, such as soccer and basketball (21,22,26), running (21,26), walking (22,24,25), cycling, snowshoeing (22), and skipping rope (27,29). Finally, only four studies reported compliance (23,25,26,28), and all of them showed above 80%.…”

Section: Aerobic Exercise Program Characteristicsmentioning

confidence: 99%

“…Finally, nine articles met all inclusion criteria and were used for the meta-analysis. Table 1 summarizes the study characteristics (21,22,23,24,25,26,27,28,29) (nZ191 and nZ176, in intervention and control groups respectively). Three studies were conducted in the USA (22,23,28), one in Germany (21), three in Korea (25,27), one in Tunisia (26), and one in Turkey (24).…”

Section: Study Selectionmentioning

confidence: 99%

“…Three studies included only boys (24,27,28) and two only girls (25,29); the remaining studies included both boys and girls (21,22,23,26). Participants were children (6-12 years old) in three studies (23,24,25), adolescents (12-18 years old) in another three studies (27,28,29), and participants of both age groups in the remaining studies (21,22,26). Several criteria were used to define obesity: four interventions used nation-specific criteria for the child population of Germany (21), Korea (25,29), and USA (Centers for Disease Control Growth Charts) (28).…”

Section: Subjectsmentioning

confidence: 99%

“…enzymatic methods (22,24,26,27) or using a glucose oxidase technique by using a radioimmunoassay (RIA) kit (25,28,29). Fasting insulin levels were determined using a chemiluminescent assay (22,27), RIA (23,26,28,29), or by an Immulite analyzer (24).…”

Section: :4 R166mentioning

confidence: 99%

“…Fasting insulin levels were determined using a chemiluminescent assay (22,27), RIA (23,26,28,29), or by an Immulite analyzer (24). One study did not provide the method for determining fasting glucose and insulin (21).…”

Section: :4 R166mentioning

confidence: 99%

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ENDOCRINOLOGY AND ADOLESCENCE: Aerobic exercise reduces insulin resistance markers in obese youth: a meta-analysis of randomized controlled trials

García-Hermoso

Saavedra

Escalante

et al. 2014

European Journal of Endocrinology

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Objective: The purpose of this meta-analysis was to examine the evidence for the effectiveness of aerobic exercise interventions on reducing insulin resistance markers in obese children and/or adolescents. A secondary outcome was change in percentage of body fat. Methods: A computerized search was made from seven databases: CINAHL, Cochrane Central Register of Controlled Trials, EMBASE, ERIC, MEDLINE, PsycINFO, and Science Citation Index. The analysis was restricted to randomized controlled trials that examined the effect of aerobic exercise on insulin resistance markers in obese youth. Two independent reviewers screened studies and extracted data. Effect sizes (ES) and 95% confidence interval (CI) were calculated, and the heterogeneity of the studies was estimated using Cochran's Q-statistic. Results: Nine studies were selected for meta-analysis as they fulfilled the inclusion criteria (nZ367). Aerobic exercise interventions resulted in decreases in fasting glucose (ESZK0.39; low heterogeneity) and insulin (ESZK0.40; low heterogeneity) and in percentage of body fat (ESZK0.35; low heterogeneity). These improvements were specifically accentuated in adolescents (only in fasting insulin), or through programs lasting more than 12 weeks, three sessions per week, and over 60 min of aerobic exercise per session. Conclusions: This meta-analysis provides insights into the effectiveness of aerobic exercise interventions on insulin resistance markers in the obese youth population.

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Section: Aerobic Exercise Program Characteristicsmentioning

confidence: 99%

Section: Study Selectionmentioning

confidence: 99%

Section: Subjectsmentioning

confidence: 99%

Section: :4 R166mentioning

confidence: 99%

Section: :4 R166mentioning

confidence: 99%

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ENDOCRINOLOGY AND ADOLESCENCE: Aerobic exercise reduces insulin resistance markers in obese youth: a meta-analysis of randomized controlled trials

García-Hermoso

Saavedra

Escalante

et al. 2014

European Journal of Endocrinology

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Exercise and Insulin Resistance Markers in Children and Adolescents With Excess Weight

García-Hermoso,

López-Gil,

Izquierdo

et al. 2023

JAMA Pediatr

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ImportanceAlthough benefits have been reported for most exercise modalities, the most effective exercise approaches for reducing insulin resistance in children and adolescents with excess weight and the optimal exercise dose remain unknown.ObjectiveTo compare exercise training modalities and their association with changes in insulin resistance markers among children and adolescents with excess weight and to establish the optimal exercise dose.Data SourcesFor this systematic review and network meta-analysis, 6 electronic databases (PubMed, EMBASE, Cochrane Central Register of Controlled Trials, Scopus, Web of Science, and CINAHL) were searched for studies from inception to April 1, 2023.Study SelectionRandomized clinical trials (ie, randomized controlled trials and randomized trials without a control group) were included if they reported outcomes associated with aerobic training, resistance training, high-intensity interval training (HIIT), or a combination of these interventions.Data Extraction and SynthesisData extraction for this systematic review was conducted following a network meta-analysis extension of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses reporting guideline. Effect sizes were calculated as the mean difference (MD) with 95% CI using random-effects inverse-variance models with the Hartung-Knapp-Sidik-Jonkman method. The hierarchy of competing interventions was defined using the surface under the cumulative ranking curve. The Cochrane Risk-of-Bias tool, version 2 (RoB2), was used to independently assess the risk of bias of the included studies. The certainty of evidence in consistent networks was assessed using the Grading of Recommendation, Assessment, Development and Evaluation approach. The study protocol was prospectively registered with PROSPERO. Data analyses were conducted between May and June 2023.Main Outcomes and MeasuresThe primary outcomes were fasting glucose, insulin, and homeostatic model assessment for insulin resistance (HOMA-IR).ResultsThis analysis included 55 studies with a total of 3051 children and adolescents (mean [SD] age, 13.5 [2.3] years; 1537 girls [50.4%] and 1514 boys [49.6%]). Exercise was associated with reductions in fasting insulin (MD, −4.38 μU/mL [95% CI, −5.94 to −2.82 μU/mL]) and HOMA-IR (MD, –0.87 [95% CI, –1.20 to –0.53]). A nonlinear association in both markers was observed, with a required minimal exercise dosage of approximately 900 to 1200 metabolic equivalent of task minutes per week, especially in children and adolescents with insulin resistance at baseline. Combination HIIT and resistance training and concurrent training were the most effective approaches for reducing insulin resistance markers. On average, the certainty of evidence varied from low to moderate.Conclusions and RelevanceThese findings underscore the role of exercise interventions in enhancing insulin resistance markers among children and adolescents with overweight and obesity. It is advisable to include resistance exercises alongside aerobic and HIIT programs for a minimum of two to three 60-minute sessions per week.

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Metabolic Cardiovascular Risk Factors

Sagiv

2012

Exercise Cardiopulmonary Function in Cardiac Patients

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Exercise improves the ApoB/ApoA‐I ratio, a marker of the metabolic syndrome in obese children

Abstract: Training targeted at Fat max reduces the prevalence of metabolic syndrome and its associated factors in obese children. In particular, this intervention decreases the ApoB/ApoA-I ratio, which may be considered as a marker for following this syndrome.

Cited by 47 publications

References 25 publications

ENDOCRINOLOGY AND ADOLESCENCE: Aerobic exercise reduces insulin resistance markers in obese youth: a meta-analysis of randomized controlled trials

ENDOCRINOLOGY AND ADOLESCENCE: Aerobic exercise reduces insulin resistance markers in obese youth: a meta-analysis of randomized controlled trials

Exercise and Insulin Resistance Markers in Children and Adolescents With Excess Weight

Metabolic Cardiovascular Risk Factors

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