Exercise Improves Clinical Symptoms, Quality of Life, Global Functioning, and Depression in Schizophrenia: A Systematic Review and Meta-analysis

Dauwan, Meenakshi; Begemann, Marieke J H; Heringa, Sophie M.; Sommer, Iris E.

doi:10.1093/schbul/sbv164

Cited by 306 publications

(252 citation statements)

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“…A systematic review of 39 trials found that engaging in regular physical activity resulted in fewer depressive symptoms, greater aerobic capacity, and improved quality of life among people with mental illnesses including schizophrenia and bipolar disorder (Rosenbaum et al, 2014). Recent meta-analyses have also demonstrated that physical activity contributes to reduction in mental health symptom severity among people with serious mental illness (Dauwan et al, 2015; Firth et al, 2015a). …”

Section: Introductionmentioning

confidence: 99%

Wearable devices and mobile technologies for supporting behavioral weight loss among people with serious mental illness

Naslund

Aschbrenner

Scherer

et al. 2016

Psychiatry Research

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Promoting physical activity is essential for addressing elevated cardiovascular risk and high obesity rates affecting people with serious mental illness. Numerous challenges interfere with exercise participation in this high-risk group including mental health symptoms, low motivation, and limited access to safe and affordable options for physical activity. Wearable devices and mobile health technologies may afford new opportunities for promoting physical activity and supporting behavioral weight loss efforts. This exploratory study examined whether daily step count measured using Fitbit wearable devices was associated with weight loss and improved fitness among individuals with serious mental illness enrolled in a 6-month lifestyle program. Participants (n=34) had a schizophrenia spectrum disorder (23.5%), major depression (50.0%), or bipolar disorder (26.5%), and wore Fitbits most of the days (M=86.2%; SD=18.4%) they were enrolled in the study. At 6-months, higher average daily step count was associated with greater weight loss (F=5.07; df=1,32; p=0.0314), but not improved fitness (F=1.92; df=1,31; p=0.176). These findings demonstrate that encouraging participants with serious mental illness enrolled in lifestyle interventions to collect more steps may contribute to greater weight loss. This suggests that wearable devices may offer a feasible and potentially effective strategy for supporting behavioral weight loss in community mental health settings.

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Section: Introductionmentioning

confidence: 99%

Wearable devices and mobile technologies for supporting behavioral weight loss among people with serious mental illness

Naslund

Aschbrenner

Scherer

et al. 2016

Psychiatry Research

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“…The MATRICS Consensus Cognitive Battery includes 7 domains that are considered necessary for a complete evaluation of cognitive functioning in schizophrenia [12]. However, most previous studies have only investigated the correlation between physical activity and memory or general cognitive function [13]. …”

Section: Introductionmentioning

confidence: 99%

Correlations between physical activity and neurocognitive domain functions in patients with schizophrenia: a cross-sectional study

Kurebayashi

Otaki

2017

BMC Psychiatry

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BackgroundNeurocognitive dysfunction is a critical target symptom of schizophrenia treatment. A positive correlation between physical activity level and neurocognitive function has been reported in healthy individuals, but it is unclear whether such a correlation exists in patients with schizophrenia and whether the relationship is different according to inpatients or outpatients. This study aimed to examine the differences in the correlations between physical activity and multiple neurocognitive domains in inpatients and outpatients with schizophrenia and obtain suggestions for further study to facilitate this field.MethodsTwenty-nine patients with schizophrenia were examined (16 inpatients and 13 outpatients, 56.0 ± 11.4 years of age). Current symptoms were assessed using the Positive and Negative Symptom Scale and neurocognitive functions using Cognitrax, which yields a composite neurocognitive index (NCI) and 11 domain scores. After testing, participants wore an HJA-750C accelerometer for one week to measure physical activity levels and durations. Partial correlation analyses were performed between exercise and cognitive parameters.ResultsIn the outpatient group, higher physical activity was associated with faster Motor and Psychomotor Speeds in outpatients. However, higher physical activity was associated with lower overall NCI, Attention score, and Memory scores in inpatients.ConclusionAlthough higher physical activity was associated with better neurocognitive functions of outpatients, in inpatients with non-remitted schizophrenia, higher physical activity was associated with worsening of several cognitive domains. In a future study examining the relationship between physical activity and neurocognitive function for facilitating this research field, separation between inpatients and outpatients are needed because the relationship is different between inpatients and outpatients.Electronic supplementary materialThe online version of this article (doi:10.1186/s12888-016-1176-z) contains supplementary material, which is available to authorized users.

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“…While one recent meta-analysis on humans supports exercise as "a robust add-on treatment" (Dauwan et al, 2015) in schizophrenia, its efficacy is often hard to establish in clinical reality. Indeed, a different meta-analysis of n = 94 schizophrenic patients did not support the hypothesis that physical exercise leads to clinically relevant weight loss in schizophrenia (Krogh et al, 2014).…”

Section: Outlook: Possible New Therapies For Comorbid Obesitymentioning

confidence: 99%

Altered reward anticipation: Potential explanation for weight gain in schizophrenia?

Grimm

Kaiser

Plichta

et al. 2017

Neuroscience & Biobehavioral Reviews

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a b s t r a c tObesity and weight gain are severe complications of mental illness, especially schizophrenia. They result from changes in lifestyle and nutrition, side effects of medication and other, less well-understood factors. Recent studies suggest that obesity and weight gain are linked to psychopathology. Specifically, severe psychopathology is associated with greater weight dysregulation, typically weight gain. However, our knowledge about the neuroscientific basis of weight gain in schizophrenia is currently limited. We propose that altered reward anticipation, which in turn is related to striatal dopaminergic dysregulation, may explain why obesity is more prevalent in individuals with mental illness. We review evidence that reward anticipation and weight change are linked by a core deficit in dopaminergic striatal circuits. Several lines of evidence, running from animal studies to preclinical and clinical studies, suggest that striatal dopaminergic neurotransmission is a major hub for the regulation of eating behavior and that dopamine links eating behavior to other motivated behavior. From this perspective, the present review outlines a unifying perspective on dopaminergic reward anticipation as a theoretical frame to link weight gain, medication effects and psychopathology. We derive important but open empirical questions and present perspectives for new therapeutic concepts.

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Exercise Improves Clinical Symptoms, Quality of Life, Global Functioning, and Depression in Schizophrenia: A Systematic Review and Meta-analysis

Abstract: Physical exercise is a robust add-on treatment for improving clinical symptoms, quality of life, global functioning, and depressive symptoms in patients with schizophrenia. The effect on cognition is not demonstrated, but may be present for yoga.

Cited by 306 publications

References 145 publications

Wearable devices and mobile technologies for supporting behavioral weight loss among people with serious mental illness

Wearable devices and mobile technologies for supporting behavioral weight loss among people with serious mental illness

Correlations between physical activity and neurocognitive domain functions in patients with schizophrenia: a cross-sectional study

Altered reward anticipation: Potential explanation for weight gain in schizophrenia?

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