Exercise improves adiponectin concentrations irrespective of the adiponectin gene polymorphisms SNP45 and the SNP276 in obese Korean women

Lee, Kyoung-Young; Kang, Hyunah; Shin, Yun-A

doi:10.1016/j.gene.2012.12.028

Cited by 14 publications

(14 citation statements)

References 32 publications

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“…Our findings may offer potential mechanisms to the observations in small intervention studies suggesting that exercise training may increase adiponectin levels independently of weight loss and of adiponectin gene polymorphisms (31) and are in agreement with a growing body of literature showing that adipose tissue function (of which adiponectin is a marker) may be independent of adiposity (1) and that cardiorespiratory fitness and adiponectin levels are related (44). We acknowledge that our study has several strengths, as well as limitations.…”

Section: Discussionsupporting

confidence: 86%

A common variant in the CLDN7/ELP5 locus predicts adiponectin change with lifestyle intervention and improved fitness in obese individuals with diabetes

Belalcazar

Papandonatos

McCaffery

et al. 2015

Physiological Genomics

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Overweight/obese individuals with Type 2 diabetes have low adiponectin levels, which may improve with lifestyle changes. We investigated whether genetic variants associated with adiponectin levels in genome-wide association studies (GWAS) would also be related with adiponectin changes in response to an intensive lifestyle intervention (ILI), potentially through mechanisms altering the adipose microenvironment via weight loss and/or improved cardiorespiratory fitness. Look AHEAD was a randomized trial comparing the cardiovascular benefits of ILI-induced weight loss and physical activity compared with diabetes support and education among overweight/obese individuals with Type 2 diabetes. In a subsample of Look AHEAD with adiponectin data and genetic consent (n=1,351), we evaluated the effects of 24 genetic variants, demonstrated by GWAS to be cross-sectionally associated with adiponectin, on adiponectin change 1-yr postintervention. We explored via mediational analyses whether any differential effects by treatment arm were occurring through weight loss and/or improved fitness. A variant, rs222857, in the CLDN7 locus, potentially associated with epithelial barrier integrity and tight junction physiology, and a putative cis expression quantitative trail locus for elongator acetyltransferase complex subunit 5 (ELP5), predicted adiponectin increases within ILI (log-adiponectin in overall sample per copy: β±SE=0.05±0.02, P=0.008; in non-Hispanic whites: 0.06±0.02, P=0.009). The favorable effects of rs222857 (minor allele frequency 45.5%) appeared to be mediated by mechanisms associated with improved fitness, and not weight loss. This is the first study to identify a genetic variant that modifies adiponectin response to lifestyle intervention in overweight/obese diabetic individuals.

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Section: Discussionsupporting

confidence: 86%

A common variant in the CLDN7/ELP5 locus predicts adiponectin change with lifestyle intervention and improved fitness in obese individuals with diabetes

Belalcazar

Papandonatos

McCaffery

et al. 2015

Physiological Genomics

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“…A definitive conclusion on this ADIPOQ polymorphism cannot be made due to the lack of replication and because the direction of the association was opposite with the ADIPOQ C-11377G genotype between the ROSI and PIO studies. Studies have shown that exercise affects adiponectin concentrations (Gueugnon et al, 2012; Lee et al, 2013). The Korean study reported that exercise increased adiponectin levels irrespective of ADIPOQ polymorphisms (Lee et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

Current clinical evidence on pioglitazone pharmacogenomics

Kawaguchi‐Suzuki

Frye

2013

Front. Pharmacol.

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Pioglitazone is the most widely used thiazolidinedione and acts as an insulin-sensitizer through activation of the Peroxisome Proliferator-Activated Receptor-γ (PPARγ). Pioglitazone is approved for use in the management of type 2 diabetes mellitus (T2DM), but its use in other therapeutic areas is increasing due to pleiotropic effects. In this hypothesis article, the current clinical evidence on pioglitazone pharmacogenomics is summarized and related to variability in pioglitazone response. How genetic variation in the human genome affects the pharmacokinetics and pharmacodynamics of pioglitazone was examined. For pharmacodynamic effects, hypoglycemic and anti-atherosclerotic effects, risks of fracture or edema, and the increase in body mass index in response to pioglitazone based on genotype were examined. The genes CYP2C8 and PPARG are the most extensively studied to date and selected polymorphisms contribute to respective variability in pioglitazone pharmacokinetics and pharmacodynamics. We hypothesized that genetic variation in pioglitazone pathway genes contributes meaningfully to the clinically observed variability in drug response. To test the hypothesis that genetic variation in PPARG associates with variability in pioglitazone response, we conducted a meta-analysis to synthesize the currently available data on the PPARG p.Pro12Ala polymorphism. The results showed that PPARG 12Ala carriers had a more favorable change in fasting blood glucose from baseline as compared to patients with the wild-type Pro12Pro genotype (p = 0.018). Unfortunately, findings for many other genes lack replication in independent cohorts to confirm association; further studies are needed. Also, the biological functionality of these polymorphisms is unknown. Based on current evidence, we propose that pharmacogenomics may provide an important tool to individualize pioglitazone therapy and better optimize therapy in patients with T2DM or other conditions for which pioglitazone is being used.

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“…These common SNPs affect type 2 diabetes mellitus, metabolic syndrome, and coronary heart disease in the chromosome 3q27 region. Therefore, the relationship between APM-1 SNPs on chromosome 3q27 and these diseases, particularly for the adiponectin 45 and 276 loci, have received increasing attention (Pischon et al, 2007;Foucan et al, 2010;Jing et al, 2012;Arnaiz-Villena et al, 2013;Lee et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Association between polymorphisms in the adiponectin gene (APM-1) and atherosclerotic cerebral infarction in a Hainan Chinese Han population

Chen

Ding

2015

Genet. Mol. Res.

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ABSTRACT. We investigated the association between polymorphisms in the adiponectin gene (APM-1) and atherosclerotic cerebral infarction (ACI) in a Chinese Han population of Hainan Province. Polymerase chain reaction-restriction fragment length polymorphism and gene sequencing were used to analyze the distribution of APM-1 +45T/G and +276G/T genotypes and their alleles in 120 ACI patients and 120 healthy controls. No statistical correlation was found in the frequency and distribution of the genotype 45T/G between the ACI group and the control group. Genotypic frequencies of GG, GT, and TT at the APM-1 +276 locus were 70.0% (84/120), 25.0% (30/120), and 5.0% (6/120), respectively, in the ACI group, while these values were 52.5% (63/120), 37.5% (45/120), and 10.0% (12/120), respectively, in the control group. The frequency of the G allele was 82.5% (198/240) in the ACI group and 71.25% (171/240) in the control group. The T allele frequency was 17.5% (42/240) in the ACI group and 28.75% (69/240) in the control group. Polymorphisms at the APM-1 -276 locus in the case-controlled 4143 Associations between polymorphisms in APM-1 gene and ACI ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 4142-4149 (2015) groups showed significant differences in the genotype distribution and allele frequency between the 2 groups (P = 0.041). The occurrence of ACI in the Hainan Chinese Han population may be associated with +276G/T polymorphisms but not with +45T/G polymorphisms in the APM-1 gene.

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Exercise improves adiponectin concentrations irrespective of the adiponectin gene polymorphisms SNP45 and the SNP276 in obese Korean women

Cited by 14 publications

References 32 publications

A common variant in the CLDN7/ELP5 locus predicts adiponectin change with lifestyle intervention and improved fitness in obese individuals with diabetes

A common variant in the CLDN7/ELP5 locus predicts adiponectin change with lifestyle intervention and improved fitness in obese individuals with diabetes

Current clinical evidence on pioglitazone pharmacogenomics

Association between polymorphisms in the adiponectin gene (APM-1) and atherosclerotic cerebral infarction in a Hainan Chinese Han population

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