Exercise, Free Radical Metabolism, and Aging: Cellular and Molecular Processes

Florida-James, Geraint; Simpson, Richard; Davison, Gareth W.; Close, Graeme L.

doi:10.1155/2016/3813680

Cited by 9 publications

(4 citation statements)

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“…Production of free radicals is an unavoidable process in the course of cellular metabolism. 4 There is evidence that oxidative stress, exerting downstream effects such as lipid peroxidation, DNA damage and mitochondrial impairment, may play a fatal role in senility. 5 Indeed, there are many factors to which the organism is exposed like smoke, microorganisms, or UV radiation, that can induce anti stress responses, leading to the generation of ROS.…”

Section: Introductionmentioning

confidence: 99%

Structural characterization of peptides fromLocusta migratoria manilensis(Meyen, 1835) and anti-aging effect inCaenorhabditis elegans

et al. 2019

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Section: Introductionmentioning

confidence: 99%

Structural characterization of peptides fromLocusta migratoria manilensis(Meyen, 1835) and anti-aging effect inCaenorhabditis elegans

et al. 2019

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“…[10][11][12] Free radicals have a strong oxidizing ability that breaks down cells, producing a series of irreversible damage and affecting normal cell metabolism, accelerating the aging of the body. 13 Meanwhile, hyperlipidemia promotes the deposition of fat in the blood vessels, decreasing the speed of blood flow through the arteries and increasing the risk of CVD and related mortality. 14,15 Previous studies have shown that a 70% ethanol extract of C oleifera has antioxidant and antimelanogenic activities.…”

Section: Introductionmentioning

confidence: 99%

Camellia oil Enhances Plasma Antioxidant Metabolism and Improves Plasma Lipid Metabolism in High-fat Diet-fed Rats

Shi

Zhou

XiaoE³

et al. 2022

Natural Product Communications

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Living on a high-fat, high-calorie, and high-protein diet for a long period may compromise human immunity due to the long-term accumulation of free radicals and plasma lipids. The antioxidant and lipid-lowering compounds (ie polyphenols and vitamin E) in Camellia oil help to decrease the risk of numerous ailments, including cardiovascular disease (CVD), and obesity. The aims of this study were to study the hypolipidemic and antioxidant effects of Camellia oil in high-fat-fed rats and to promote the high-value use of camellia resources. The high-fat-fed rats were administrated with 2.5, 7.5, and 15 mL/kg BW Camellia oil (Camellia oil group), and 10 mg/kg BW atorvastatin (atorvastatin group), respectively, and compared with a model group (only fed with high fat) and a control group (fed with basal diet). Several parameters were measured, including (1) body weight (BW), liver-to-BW ratio; (2) plasma total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C); and (3) alanine aminotransferase (ALT), alanine aminotransferase (AST), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activity, model driven architecture (MDA) content, lipid metabolism-related genes, and antioxidant-related genes in liver tissue. Compared with the model group, the high-fat-fed rats in the Camellia oil and atorvastatin group had significantly lower BW and liver-to-BW ratio ( P < .01), plasma TC, TG, and LDL-C levels and ALT and AST activities, but higher HDL-C levels. The relative expressions of ACAT1, DGAT2, FAS, and SREBP genes were significantly reduced in the Camellia oil and atorvastatin groups, while the relative expressions of LCAT, UCP2, MCD, and CPT-1 genes were significantly increased. The rats in the Camellia oil group showed significantly higher SOD and GSH-Px activities, significantly lower MDA content, and significantly higher relative expression of antioxidant genes (eg SOD1, GPx1, CAT, and Gclm). Thus, atorvastatin and Camellia oil exhibited significant hypolipidemic and antioxidant effects, which were better at a dose of 7.5 mL/kg (BW) of Camellia oil. Therefore, Camellia oil becomes a potential new natural resource for future research and development of antioxidant and hypolipidemic drugs, nutraceuticals, and additives.

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“…EDF has also been linked to the fatigued state of a person. Therefore in a state of disruption due to pro-inflammation, it can lead to diminished quality of life (QoL) and cardiac endurance of an individual [21,22]. It is also worth mentioning, long term inflammation coincides with abnormally low levels of high density lipoproteincholesterol (HDL-c) in overweight individuals [23,24].…”

Section: Introductionmentioning

confidence: 99%

Effect of Oxyjun™ on Adipose Tissue Inflammation - A Randomized, Placebo-Controlled Clinical Study

Srivastava

Girandola

Kokate

2020

Int. J. Phys. Educ. Fit. Sports

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The objective of the study was to explore the effect of Oxyjun™ on the cardiovascular function of overweight people by reducing obesity induced systemic inflammation. Males aged between 18 - 35 years and body mass index of 25 - 34.9 kg/m2 were recruited in the study. Participants were randomized on baseline visit in two groups to receive either single dose of 400 mg of Oxyjun™ and placebo (for 8-weeks. Participants were evaluate for obesity related inflammation and quality of life using the change in neutrophil lymphocyte ratio (NLR), high density lipoprotein (HDL-c) and 36 items short form survey (SF-36). NLR was reduced by 0.71 in the Oxyjun™ group and by 0.42 in the placebo group. Within group comparison was significant for Oxyjun™ when compared from baseline (p<0.001) and reduction of NLR in Oxyjun™ group was more than 1.5 times higher than that of placebo. HDL-c levels were improved in the Oxyjun™ group with an increase of 4.04 mg/dL whereas, HDL-c was reduced in the placebo group by 1.22 mg/dL; p=0.09. Further, SF-36 health concepts of fatigue, mental health, and social function showed significant improvement and also the pain scores were improved. No adverse or serious adverse events were reported for the Oxyjun™ as well as the placebo group during the study. Oxyjun™ reduced the NLR of participants demonstrating its potential for lowering adipose tissue induced inflammation. Further, increased HDL levels in Oxyjun™ group can assist in promoting cardiovascular fitness and prevent the risk of future cardiovascular events.

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Exercise, Free Radical Metabolism, and Aging: Cellular and Molecular Processes

Cited by 9 publications

References 0 publications

Structural characterization of peptides fromLocusta migratoria manilensis(Meyen, 1835) and anti-aging effect inCaenorhabditis elegans

Structural characterization of peptides fromLocusta migratoria manilensis(Meyen, 1835) and anti-aging effect inCaenorhabditis elegans

Camellia oil Enhances Plasma Antioxidant Metabolism and Improves Plasma Lipid Metabolism in High-fat Diet-fed Rats

Effect of Oxyjun™ on Adipose Tissue Inflammation - A Randomized, Placebo-Controlled Clinical Study

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