Exercise for physical fitness, fatigue and quality of life of patients undergoing hematopoietic stem cell transplantation: a meta-analysis of randomized controlled trials

Liang

J of Obstet and Gynaecol

2019

Self Cite

Aim To identify the characteristics of fear of cancer recurrence (FCR) in breast cancer patients after surgery and investigate the relationship of FCR with demographic and medical characteristics, quality of life (QOL) and social support. Methods The short version of the Fear of Progression Questionnaire (FoP‐Q‐SF), the functional assessment of cancer therapy for breast cancer (FACT‐B) and the Social Support Rating Scale were administered to the 342 breast cancer patients who had undergone surgical treatment. The analysis was performed to determine potential predictors associated with FCR. Results Of the 465 patients, 342 (73.5%) agreed to take part in the study. The mean age of participants was 51.46 ± 10.50 years (range, 30–81). Of the 342 participants, 92 (26.9%) cases were at Stage I, 131 (38.3%) cases at Stage II, 34 (9.9%) patients at Stage III and 85 (24.9%) patients at Stage IV. Among the 12 items of the FoP‐Q‐SF, the three greatest fears were: Item 10 ‘Worrying that medications could damage the body’, Item 1 ‘Being afraid of disease progression’ and Item 2 ‘Being nervous prior to doctors’ appointments or periodic examinations’. About 68.4% of patients reported the dysfunctional level of fear of progression. Multiple linear regression analysis showed that religious belief, family income, disease stages, social support, QOL were identified as independent predictors for FCR. Conclusion We found that FCR is prevalent in postoperative breast cancer patients, and is influenced by many factors. It is necessary to implement positive intervention measures to alleviate the FCR and improve the QOL of patients.

Section: Discussionsupporting

confidence: 51%

“…Quality of life as an important predictor of patient survival has become more and more valued . In this study, social/family well‐being, emotional well‐being and additional concerns proved negatively correlated with FCR.…”

Section: Discussionmentioning

confidence: 64%

Factors influencing fear of cancer recurrence in patients with breast cancer: Evidence from a survey in Yancheng, China

Liang

J of Obstet and Gynaecol

2019

Self Cite

“…Despite this, studies have shown that it is possible for these patients to increase their levels of PA and benefit from this. A recent metaanalysis confirmed that early PE might help prevent decline in muscle strength arising from immobility and prolonged bed rest in HSCT patients [32]. In the late 1990s, Dimeo et al proposed a bicycle made for bedridden patients [11], while other studies have randomised patients to standard care or daily exercise programmes encompassing a wide variety of tools, such as bicycles and strength training equipment, to increase PA during hospital stays [12,13].…”

Section: Discussionmentioning

confidence: 99%

“…Based on the findings from our study, it seems effective to have a pre-transplantation appointment with HSCT patients talking about the importance of being physically active. Liang et al concluded, in a meta-analysis, that the optimal timing of PA for HSCT patients is pre-transplantation [32]. Previous studies have concluded that supervised exercise prior to HSCT is safe and feasible [37] and that patients in partly self-administered pre-transplantation PE programmes can become stronger and achieve better physical condition compared with a control group [38].…”

Section: Discussionmentioning

confidence: 99%

Is it possible to increase the amount of physical activity in patients isolated due to stem cell transplantation?

Vejby¹

2019

Preprint

Purpose: To investigate if physical activity (PA) support could increase PA and health-related quality of life (HRQoL) in patients isolated after haematological stem cell transplantation, compared with standard care. Methods: A prospective historical control group design was used. Patients were sequentially included in a standard care group (SCG, n=22) or a physical activity support group (PASG, n=21). PASG patients received PA support at a pre-transplantation consultation, daily during admission, and at follow-up 14 days post-discharge. All participants undertook a 6-minute walking test (6MWT) at the beginning and end of their hospital stay. HRQoL was evaluated using the Functional Assessment of Cancer Therapy – Anaemia scale. Patients reported all PA, including sitting, throughout their hospital stay. Metabolic Equivalents of Task (METs) were calculated. Results: PASG patients spent more time sitting and doing various activities, and less in bed, than SCG patients (p=0.03–0.06). They had more calculated METs for total PA out of bed (p=0.02) and time spent sitting (p=0.05). PASG patients walked further in the 6MWT than SCG patients at baseline (p=0.02) and at discharge, but not significantly. There were no statistically significant differences in HRQoL, but PASG patients had clinically important less fatigue at discharge and clinically important better HRQoL 6 months post-discharge. Conclusions: Providing stem cell patients, pre-transplantation, with individual care plans for structured PA support during the hospital stay might increase PA and have a clinically important impact on HRQoL. Larger studies are needed to evaluate the effects of PA support on medical outcome and length of hospital stay.

“…Guidelines recommend people with cancer participate in three times weekly aerobic and twice-weekly resistance exercise training to improve health outcomes [8]. Exercise training reduces fatigue, improves strength and quality of life in people who have received autologous stem cell transplant [9,10]. However, it is unknown how best to deliver exercise-based rehabilitation for people receiving autologous stem cell transplant.…”

Section: Introductionmentioning

confidence: 99%

Prehabilitation to Improve outcomes afteR Autologous sTem cEll transplantation (PIRATE): A pilot randomised controlled trial protocol

Dennett¹,

Porter²,

Ting³

et al. 2020

Preprint

BackgroundAutologous stem cell transplant is a common procedure for people with haematological malignancies. While effective at improving survival, autologous stem cell transplant recipients may have a lengthy hospital admission and experience debilitating side-effects such as fatigue, pain and deconditioning that may prolong recovery. Prehabilitation comprising exercise and nutrition intervention before stem cell transplant aims to optimise physical capacity before the procedure to enhance functional recovery after transplant. However, few studies have evaluated prehabilitation in this setting. We aim to determine preliminary efficacy of improving physical capacity of prehabilitation for people undergoing autologous stem cell transplant. MethodsThe PIRATE study is a single-blinded, parallel two-armed pilot randomised trial of multidisciplinary prehabilitation delivered prior to autologous stem cell transplantation. Twenty-two patients with haematological malignancy waitlisted for transplant will be recruited from a tertiary haematology unit. The intervention will include up to 8 weeks of twice-weekly, in-person, supervised tailored exercise and fortnightly nutrition education delivered via phone, in the lead up to autologous stem cell transplant. Blinded assessments will be completed at week 13, approximately 4 weeks after transplant and health service measures collected at week 25 approximately 12 weeks after transplant. The primary outcome is to assess changes in physical capacity using the 6-minute walk test. Secondary measures are time to engraftment, C-reactive protein, physical activity (accelerometer), grip strength, health-related quality of life (EORTC QLQ-C30 and HDC29 supplement), self-efficacy and recording of adverse events. Additionally, health service data including hospital length of stay, hospital readmissions, emergency department presentations and urgent symptom clinic presentation at 6 months will be recorded. DiscussionThis trial will provide valuable information that will inform a future definitive randomised controlled trial and implementation of prehabilitation for people receiving autologous stem cell transplant by providing data on efficacy and safety. Trial registrationThe PIRATE Trial has been approved by the Eastern Health Human Research Ethics Committee (E20/003/61055) and is funded by the Eastern Health Foundation. This trial is registered with the Australian New Zealand Clinical Trials Registry ACTRN12620000496910. Registered April 20, 2020, https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=379441&isReview=true