Exercise for intermittent claudication

Lane, Risha; Ellis, Brian; Watson, Lorna; Leng, Gillian

doi:10.1002/14651858.cd000990.pub3

Cited by 164 publications

(183 citation statements)

References 156 publications

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“…Our laboratory (65) and others (27) have shown that exercise training promotes a substantial improvement in functional capacity in patients with IC. This effect is thought to be mediated in part by an increase in skeletal muscle capillarization, which enhances the surface area for oxygen delivery and nutrient exchange (14).…”

Section: Discussionmentioning

confidence: 84%

Effects of oral N-acetylcysteine on walking capacity, leg reactive hyperemia, and inflammatory and angiogenic mediators in patients with intermittent claudication

Silva

Roseguini

Chehuen

et al. 2015

American Journal of Physiology-Heart and Circulatory Physiology

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Section: Discussionmentioning

confidence: 84%

Effects of oral N-acetylcysteine on walking capacity, leg reactive hyperemia, and inflammatory and angiogenic mediators in patients with intermittent claudication

Silva

Roseguini

Chehuen

et al. 2015

American Journal of Physiology-Heart and Circulatory Physiology

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“…20 Participants did note experiencing loss of feeling, with symptoms of 'numbness' and/or neuropathic pain also referenced in the free text comments received. Additionally, a number of participants reported falls as a consequence of altered sensation in their feet.…”

Section: Discussionmentioning

confidence: 99%

The prevalence of self-reported lower limb and foot health problems experienced by participants with systemic lupus erythematosus: Results of a UK national survey

Cherry

Alcacer‐Pitarch

Hopkinson

et al. 2016

Lupus

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Objective: The main aim of this survey was to determine the frequency of self-reported lower limb or foot and ankle complications experienced by participants with systemic lupus erythematosus (SLE). A secondary aim was to determine the frequency of treatments that have been received or that participants with SLE may like to receive if offered. Method: A quantitative, cross-sectional, self-reported survey design was utilized. The developed survey was checked for face and content validity prior to patient partner cognitive debriefing in order to ensure usability, understanding of the process of completion and of the questions posed. The full protocol for survey development has been published previously. Results: This is the first comprehensive national UK survey of lower limb and foot health problems reported by participants with SLE. A high prevalence of vascular, dermatological and musculoskeletal complications was reported by survey respondents. Additionally, whilst the relative prevalence of sensory loss was low, a quarter of people reported having had a fall related to changes in foot sensation demonstrating a previously unknown rate and cause of falls. Conclusion: Complications related to vascular, dermatological and musculoskeletal health are identified as particularly prevalent in participants with SLE. Further, there is a suggestion that the provision of interventions to maintain lower limb health is highly varied and lacks national standardization, despite there being a strong indication of participant reported need. The findings of this work can be used to inform care guideline development in addition to identifying areas for future research. Lupus (2016) 0, 1-7.

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“…Validated training programmes show similar long term outcomes compared to endovascular therapy alone [19,20]. Prospective trials with at least three months follow-up showed improved walking distance (109 m; 95 %CI 38-180 m) and overall quality of life [21].…”

Section: Intermittent Claudicationmentioning

confidence: 93%

German guideline on the diagnosis and treatment of peripheral artery disease – a comprehensive update 2016

Lawall

Huppert

Espinola‐Klein

et al. 2017

Vasa

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Summary:The prevalence of peripheral artery disease (PAD) is increasing worldwide and is strongly age-related, affecting about 20 % of Germans over 70 years of age. Recent advances in endovascular and surgical techniques as well as clinical study results on comparative treatment methods strengthened the need for a comprehensive review of the published evidence for diagnosis, management, and prevention of PAD. The interdisciplinary guideline exclusively covers distal aorta and atherosclerotic lower extremity artery disease. A systematic literature review and formal consensus fi nding process, including delegated members of 22 medical societies and two patient self-support organisations were conducted and supervised by the Association of Scientifi c Medical Societies in Germany, AWMF. Three levels of recommendation were defi ned, A = "is recommended/ indicated", B = "should be considered", C = "may be considered", means agreement of expert opinions due to lack of evidence. Altogether 294 articles, including 34 systematic reviews and 98 RCTs have been analysed. The key diagnostic tools and treatment basics have been defi ned. In patients with intermittent claudication endovascular and/or surgical techniques are treatment options depending on appropriate individual morphology and patient preference. In critical limb ischaemia, revascularisation without delay by means of the most appropriate technique is key. If possible and reasonable, endovascular procedures should be applied fi rst. The TASC classifi cation is no longer recommended as the base of therapeutic decision process due to advances in endovascular techniques and new crural therapeutic options. Limited new data on rehabilitation and follow-up therapies have been integrated. The article summarises major new aspects of PAD treatment from the updated German Guidelines for Diagnosis and Treatment of PAD. Limited scientifi c evidence still calls for randomised clinical trials to close the present gap of evidence.Keywords: Peripheral artery disease, diagnosis, treatment, update, guideline update fi cation [2] has been the basis of the therapeutic decision process for the last decade. Its four types A-B-C-D classify peripheral atherosclerotic vascular lesions of increasing length and complexity. According to TASC, type A and B lesions were recommended to be treated endovascular-fi rst, type C and D lesions were typically fi rst addressed for surgical repair. With increasing experience of intervention and advanced stent technologies, such as drug eluted and covered stent grafts of increasing lengths, bifurcational stents, and covered angioplasty catheters, the endovascular procedures recently have become increasingly successful. Patients request non-surgical procedures as an alternative approach without risk of narcosis and lower invasive character. A renunciation from the TASC guided approach has become the consequence of the scientifi c literature evaluation.

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Exercise for intermittent claudication

Cited by 164 publications

References 156 publications

Effects of oral N-acetylcysteine on walking capacity, leg reactive hyperemia, and inflammatory and angiogenic mediators in patients with intermittent claudication

Effects of oral N-acetylcysteine on walking capacity, leg reactive hyperemia, and inflammatory and angiogenic mediators in patients with intermittent claudication

The prevalence of self-reported lower limb and foot health problems experienced by participants with systemic lupus erythematosus: Results of a UK national survey

German guideline on the diagnosis and treatment of peripheral artery disease – a comprehensive update 2016

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