Exercise for depression and depressive symptoms in older adults: an umbrella review of systematic reviews and Meta-analyses

Bigarella, Lucas Goldmann; Ballotin, Vinícius Remus; Mazurkiewicz, Lucas Ferrazza; Ballardin, Ana Carolina; Rech, Dener Lizot; Bigarella, Roberto Luis; Selistre, Luciano

doi:10.1080/13607863.2021.1951660

Cited by 20 publications

(17 citation statements)

References 42 publications

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“…Exercise has widely shown to be associated with healthier ageing phenotypes, by having been associated with a lower incidence of ageing-related chronic conditions [ 41 , 42 ] and disability at older age [ 41–43 ]. In addition, it has been shown to positively impact individual domains of functional ability such as physical performance [ 32 , 44 ], cognitive function [ 45 , 46 ] and depressive symptoms [ 47 ] in different older adults’ populations. Given that capacities are understood as overt expressions of integrated functioning of different physiological systems [ 48 ], exercise whole-organism benefits such as improved metabolic and cardiovascular health [ 49 , 50 ], muscle mass and function [ 51 , 52 ], and neurogenesis at the central nervous system [ 53 , 54 ] might underlie its effectiveness in reversing frailty [ 55–57 ], reducing the risk of late-life adverse events [ 58 , 59 ] and contributing to improve quality of life [ 60 ], even in the most vulnerable populations [ 61 , 62 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of a 12-week Vivifrail exercise program on intrinsic capacity among frail cognitively impaired community-dwelling older adults: secondary analysis of a multicentre randomised clinical trial

et al. 2022

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Introduction The World Health Organisation recently defined the construct of intrinsic capacity (IC), a function-based marker of older adult’s health encompassing all mental and physical capacities of the individual. Multicomponent physical exercise (MCE) is a potential intervention capable to maintain/increase IC at older age; however, evidence is scarce on the effects of MCE on IC in cognitively impaired pre-frail/frail older adults. Methods Secondary analyses of a randomised clinical trial. One hundred and eighty-eight older outpatients (age = 84.06 ± 4.77, 70.2% women) presenting with pre-frailty/frailty (according to Fried Criteria) and mild cognitive impairment (MCI)/mild dementia were recruited in the Geriatric clinics of three tertiary hospitals in Spain. Subjects were randomised to participate in the 12-week home-based individualised Vivifrail MCE or usual care. An IC index was created based on the z-score of the locomotion (Short Physical Performance Battery), cognitive (Montreal Cognitive Assessment), psychology (15-item Geriatric Depression Scale Yesavage) and vitality (handgrip strength) domains. Results After the 3-month intervention, linear mixed models showed significant between-group differences in the evolution of the IC composite score (β=0.48; 95% confidence interval [CI] = 0.24, 0.74; P < 0.001), IC Locomotion (β = 0.42; 95% CI = 0.10, 0.74; P < 0.001), IC Cognition (β = 0.45; 95% CI = 0.03, 0.87; P < 0.05) and IC Vitality domains (β = 0.50; 95% CI = 0.25, 0.74 at 3-month) favouring the MCE group. Conclusions The 12-week Vivifrail multicomponent exercise program is an effective strategy to enhance IC, especially in terms of locomotion, cognition and vitality IC domains in community-dwelling older adults with pre-frailty/frailty and MCI/mild dementia, compared to usual care.

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Section: Discussionmentioning

confidence: 99%

Effects of a 12-week Vivifrail exercise program on intrinsic capacity among frail cognitively impaired community-dwelling older adults: secondary analysis of a multicentre randomised clinical trial

et al. 2022

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“…In the current study, the greatest magnitude of effects was observed in mood measured with GDS, sitting blood pressure, LE strength and physical performance measured with SPPB, and cardiorespiratory aerobic capacity measured with SFT. In a recent meta-analysis that included 97 RCTs, it was identified that PE for older adults produces a moderate improvement in depression and depressive symptoms [ 57 ]. In addition, aerobic PA has been reported to increase gray-matter volume ratio and improve white-matter spatial structure in the brain, leading to greater functional connectivity in brain regions associated with major depression [ 58 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of a Structured Multicomponent Physical Exercise Intervention on Quality of Life and Biopsychosocial Health among Chilean Older Adults from the Community with Controlled Multimorbidity: A Pre–Post Design

Mena

Duran-Aguero

Parra‐Soto

et al. 2022

IJERPH

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Structured multicomponent physical exercise (PE) for older adults, with a combination of strength, aerobic, flexibility, and balance exercises, has been shown to have benefits for physical, cognitive, social, and metabolic functioning, as well as counteracting chronic pathologies and geriatric syndromes. However, little is known about the effect of these interventions in Chilean older adults. Our objective was to determine the effect of a structured multicomponent PE intervention on the quality of life (QoL) and biopsychosocial factors of community-living older adults. We conducted a pre–post intervention without control group, with a face-to-face structured multicomponent PE intervention (cardiovascular, strength/power, flexibility, static and dynamic balance, other psychomotor components, and education), based on FITT-VP principles (frequency, intensity, type, time, volume, and progression of exercise), at moderate intensity, 60 min per session, three times per week, and 12 weeks in duration, among 45 persons with an average age of 70.74 years. Participants were evaluated at the beginning and end of the intervention with different instruments of comprehensive gerontological assessment (CGA). Post intervention, participants (83.70% average attendance) significantly improved scores in QoL, biological and biopsychosocial frailty, sarcopenia, functionality in basic, instrumental, and advanced activities of daily living, dynamic balance, cognitive status and mood, systolic and diastolic blood pressure, weight, body mass index, strength and flexibility clinical tests of lower and upper extremity, aerobic capacity, agility, and tandem balance. The indication and prescription of structured multicomponent PE based on FITT-VP principles, as evaluated with the CGA, improved the QoL and biopsychosocial health of older adults. This intervention could serve as a pilot for RCTs or to improve PE programs or services for older adults under the auspices of existing public policy.

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“…In this present study, cancer survivors with low handgrip strength experienced a higher proportion of inactive than those with normal handgrip strength (85.64% versus 62.03%). Given recent meta-analysis covering 97 randomized controlled trials reporting that exercise program was associated with a lower level of depression with the pooled OR = 2.24(95%CI:1.77-2.84) 29 .…”

Section: Discussionmentioning

confidence: 99%

The association between handgrip strength and depression in cancer survivors: a cross-section study

Zhang

Chen

et al. 2021

Preprint

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BackgroundThe association between handgrip strength and depression in cancer survivors was unknown. We aim to examine the associations of handgrip strength and depression in cancer survivors by using public data (National Health and Nutrition Examination Survey). MethodsWe combined two waves of the data of the National Health and Nutrition Examination Survey during 2011-2014 to explore this important issue. The variable of handgrip strength was extracted by the maximum value of each hand. The depressive symptom was assessed by the Patient Health Questionnaire (PHQ-9) with the cut-off >=10 points indicating depressive symptoms. Other characteristics and health-related variables were evaluated. Multivariable logistic regression models were adopted to explore the associations between handgrip strength or low handgrip strength and depressive symptoms by adjusting for potential confounding factors. ResultsThere were 992 cancer survivors in our final analysis, with 456 (45.97%) male and the mean (SD) age of this whole group being 64.75 (14.02) years. The prevalence of low handgrip strength and depression was 20.36% and 13.31%, respectively. The results showed that handgrip strength was negatively associated with depression (OR=0.97,95%CI:0.96-0.99; P=0.01). In addition, after adjusting age, race, education, marital status, sleep disorder, history of stroke, polypharmacy and BMI, cancer survivors with low handgrip strength had a 2.11-fold risk of depression, compared to those with normal handgrip strength (OR=2.11,95%CI:1.19-3.73; P=0.01). ConclusionsLow handgrip strength, simple and modifiable parameter, is associated with a higher risk of depression in cancer survivors. Prospective cohort studies are warranted to confirm this association in the future.

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Exercise for depression and depressive symptoms in older adults: an umbrella review of systematic reviews and Meta-analyses

Cited by 20 publications

References 42 publications

Effects of a 12-week Vivifrail exercise program on intrinsic capacity among frail cognitively impaired community-dwelling older adults: secondary analysis of a multicentre randomised clinical trial

Effects of a 12-week Vivifrail exercise program on intrinsic capacity among frail cognitively impaired community-dwelling older adults: secondary analysis of a multicentre randomised clinical trial

Effects of a Structured Multicomponent Physical Exercise Intervention on Quality of Life and Biopsychosocial Health among Chilean Older Adults from the Community with Controlled Multimorbidity: A Pre–Post Design

The association between handgrip strength and depression in cancer survivors: a cross-section study

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