Exercise for cardiac health and regeneration: killing two birds with one stone

Verdoorn, Karine da Silva; Matsuura, Cristiane; Borges, Juliana Pereira

doi:10.21037/atm.2017.03.10

Cited by 5 publications

(4 citation statements)

References 19 publications

(19 reference statements)

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“…MicroRNAs are small noncoding RNA molecules of approximately 22 nucleotides in length modulating gene expression post-transcriptionally by binding to its target messenger RNAs promoting their degradation [84]. Several animal and human studies have shown altered miR levels in cardiac diseases such as hypertrophy, ischemic, and dilated cardiomyopathy, aortic stenosis, or arrhythmias [85,86,87,88,89,90].…”

Section: Micrornasmentioning

confidence: 99%

Molecular Mechanisms of Cardiac Remodeling and Regeneration in Physical Exercise

Schüttler

Clauß

Weckbach

et al. 2019

Cells

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Regular physical activity with aerobic and muscle-strengthening training protects against the occurrence and progression of cardiovascular disease and can improve cardiac function in heart failure patients. In the past decade significant advances have been made in identifying mechanisms of cardiomyocyte re-programming and renewal including an enhanced exercise-induced proliferational capacity of cardiomyocytes and its progenitor cells. Various intracellular mechanisms mediating these positive effects on cardiac function have been found in animal models of exercise and will be highlighted in this review. 1) activation of extracellular and intracellular signaling pathways including phosphatidylinositol 3 phosphate kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR), EGFR/JNK/SP-1, nitric oxide (NO)-signaling, and extracellular vesicles; 2) gene expression modulation via microRNAs (miR), in particular via miR-17-3p and miR-222; and 3) modulation of cardiac cellular metabolism and mitochondrial adaption. Understanding the cellular mechanisms, which generate an exercise-induced cardioprotective cellular phenotype with physiological hypertrophy and enhanced proliferational capacity may give rise to novel therapeutic targets. These may open up innovative strategies to preserve cardiac function after myocardial injury as well as in aged cardiac tissue.

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Section: Micrornasmentioning

confidence: 99%

Molecular Mechanisms of Cardiac Remodeling and Regeneration in Physical Exercise

Schüttler

Clauß

Weckbach

et al. 2019

Cells

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“…Regular exercise improves cardiac function and prevents and treats cardiovascular diseases(CVD) 1 , 2 . The cardiac benefits of exercise are related to increases in myocardial oxygen supply and consumption, reductions in myocardial fibrosis and cell apoptosis, promoting angiogenesis, improving myocardial cell survival and cardiac function in CVD 3 .…”

Section: Introductionmentioning

confidence: 99%

The mitochondrial signaling peptide MOTS-c improves myocardial performance during exercise training in rats

Yuan

Wang

Pan

et al. 2021

Sci Rep

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Cardiac remodeling is a physiological adaptation to aerobic exercise and which is characterized by increases in ventricular volume and the number of cardiomyocytes. The mitochondrial derived peptide MOTS-c functions as an important regulator in physical capacity and performance. Exercise elevates levels of endogenous MOTS-c in circulation and in myocardium, while MOTS-c can significantly enhance exercise capacity. However, the effects of aerobic exercise combined with MOTS-c on cardiac structure and function are unclear. We used pressure–volume conductance catheter technique to examine cardiac function in exercised rats with and without treatment with MOTS-c. Surprisingly, MOTS-c improved myocardial mechanical efficiency, enhanced cardiac systolic function, and had a tendency to improve the diastolic function. The findings suggest that using exercise supplements could be used to modulate the cardiovascular benefits of athletic training.

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“…For decades, the benefits of regular exercise for the therapy of heart disease have been widely recognized ( Sanchis-Gomar et al, 2015 ; Verdoorn et al, 2017 ). The fundamental basis for the positive impacts of exercise on the heart is the increase in cardiac size and output ( Pluim et al, 1998 ; Pluim et al, 2000 ).…”

Section: Introductionmentioning

confidence: 99%

The Regulatory Role of Oxygen Metabolism in Exercise-Induced Cardiomyocyte Regeneration

Zhou

et al. 2021

Front. Cell Dev. Biol.

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During heart failure, the heart is unable to regenerate lost or damaged cardiomyocytes and is therefore unable to generate adequate cardiac output. Previous research has demonstrated that cardiac regeneration can be promoted by a hypoxia-related oxygen metabolic mechanism. Numerous studies have indicated that exercise plays a regulatory role in the activation of regeneration capacity in both healthy and injured adult cardiomyocytes. However, the role of oxygen metabolism in regulating exercise-induced cardiomyocyte regeneration is unclear. This review focuses on the alteration of the oxygen environment and metabolism in the myocardium induced by exercise, including the effects of mild hypoxia, changes in energy metabolism, enhanced elimination of reactive oxygen species, augmentation of antioxidative capacity, and regulation of the oxygen-related metabolic and molecular pathway in the heart. Deciphering the regulatory role of oxygen metabolism and related factors during and after exercise in cardiomyocyte regeneration will provide biological insight into endogenous cardiac repair mechanisms. Furthermore, this work provides strong evidence for exercise as a cost-effective intervention to improve cardiomyocyte regeneration and restore cardiac function in this patient population.

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Exercise for cardiac health and regeneration: killing two birds with one stone

Cited by 5 publications

References 19 publications

Molecular Mechanisms of Cardiac Remodeling and Regeneration in Physical Exercise

Molecular Mechanisms of Cardiac Remodeling and Regeneration in Physical Exercise

The mitochondrial signaling peptide MOTS-c improves myocardial performance during exercise training in rats

The Regulatory Role of Oxygen Metabolism in Exercise-Induced Cardiomyocyte Regeneration

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