Exercise for cancer cachexia in adults

Grande, Antônio José; Silva, Valter; Maddocks, Matthew; Riera, Rachel; Medeiros, Alessandra; Vitoriano, Simone; Peccin, Maria Stella

doi:10.1002/14651858.cd010804

Cited by 12 publications

(15 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is currently insufficient evidence to determine the optimal type and dose of exercise in order to counteract cachexia in patients with advanced cancer,51 especially as both the cardiorespiratory and muscular systems are affected.…”

Section: Physical Exercisementioning

confidence: 99%

Cancer cachexia: rationale for the MENAC (Multimodal—Exercise, Nutrition and Anti-inflammatory medication for Cachexia) trial

Solheim

Laird

Balstad

et al. 2018

BMJ Support Palliat Care

Self Cite

144

110

View full text Add to dashboard Cite

Cancer cachexia is a multifactorial syndrome characterized by an on-going loss of skeletal muscle mass that cannot be fully reversed by conventional nutritional support alone. Cachexia has a high prevalence in cancer and a major impact on patient physical function, morbidity and mortality. Despite the consequences of cachexia, there is no licensed treatment for cachexia and no accepted standard of care. It has been argued that the multifactorial genesis of cachexia lends itself to therapeutic targeting through a multimodal treatment. Following a successful phase II trial, a phase III randomized controlled trial of a multimodal cachexia intervention is underway.Termed the MENAC trial (Multimodal -Exercise, Nutrition and Anti-inflammatory medication for Cachexia), this intervention is based on evidence to date and consists of Non-steroidal Antiinflammatory Drugs (NSAID) and eicosapentaenoic acid (EPA) to reduce inflammation, a physical exercise programme using resistance and aerobic training to increase anabolism, as well as dietary counselling and oral nutritional supplements to promote energy and protein balance. Herein we describe the development of this trial.

show abstract

Section: Physical Exercisementioning

confidence: 99%

Cancer cachexia: rationale for the MENAC (Multimodal—Exercise, Nutrition and Anti-inflammatory medication for Cachexia) trial

Solheim

Laird

Balstad

et al. 2018

BMJ Support Palliat Care

Self Cite

144

110

View full text Add to dashboard Cite

show abstract

“…Ongoing clinical trials, however, are exploring the potential benefits of exercise for cancer cachexia within a multimodal approach. 72 …”

Section: Options For Prevention and Treatmentmentioning

confidence: 99%

Cancer-induced muscle wasting: latest findings in prevention and treatment

2017

View full text Add to dashboard Cite

Cancer cachexia is a severe and disabling clinical condition that frequently accompanies the development of many types of cancer. Muscle wasting is the hallmark of cancer cachexia and is associated with serious clinical consequences such as physical impairment, poor quality of life, reduced tolerance to treatments and shorter survival. Cancer cachexia may evolve through different stages of clinical relevance, namely pre-cachexia, cachexia and refractory cachexia. Given its detrimental clinical consequences, it appears mandatory to prevent and/or delay the progression of cancer cachexia to its refractory stage by implementing the early recognition and treatment of the nutritional and metabolic alterations occurring during cancer. Research on the molecular mechanisms underlying muscle wasting during cancer cachexia has expanded in the last few years, allowing the identification of several potential therapeutic targets and the development of many promising drugs. Several of these agents have already reached the clinical evaluation, but it is becoming increasingly evident that a single therapy may not be completely successful in the treatment of cancer-related muscle wasting, given its multifactorial and complex pathogenesis. This suggests that early and structured multimodal interventions (including targeted nutritional supplementation, physical exercise and pharmacological interventions) are necessary to prevent and/or treat the devastating consequences of this cancer comorbidity, and future research should focus on this approach.

show abstract

“…Two review authors (A.J.G., V.S.) independently assess titles and abstracts of articles for relevance . We extracted relevant data relating to the study source, methods, participants, and intervention, Disagreements were discussed and resolved by consensus.…”

Section: Methodsmentioning

confidence: 99%

“…Despite a growing evidence base for nutritional and drug interventions for cancer cachexia, studies of exercise in advanced cancer are few. This paper provides an executive summary of a recent Cochrane Collaboration systematic review, which synthesizes evidence for the use of exercise for cancer cachexia.…”

Section: Introductionmentioning

confidence: 99%

Exercise for cancer cachexia in adults: Executive summary of a Cochrane Collaboration systematic review

Grande

Silva

Maddocks

2015

Journal of Cachexia, Sarcopenia and Muscle

Self Cite

View full text Add to dashboard Cite

BackgroundCancer cachexia is a complex syndrome characterized by an ongoing loss of skeletal muscle mass and progressive functional impairment. A proactive management approach is recommended, including physical exercise to maintain function via modulation of muscle metabolism, insulin sensitivity and levels of inflammation. The review aimed to determine the safety, acceptability and effectiveness of exercise in adults with cancer cachexia. Secondary aims, subject to the data availability, were to compare effectiveness according to the characteristics of the study intervention or population.MethodsWe sought randomised controlled trials (RCTs) in adults meeting international criteria for cancer cachexia, comparing a programme of exercise as a sole or adjunct intervention to usual care or an active control. CENTRAL, MEDLINE, EMBASE, DARE and HTA, ISI Web of Science, LILACS, PEDro, SciVerse SCOPUS, Biosis Previews PreMEDLINE and Open Grey databases were searched up to June 2014. Two authors independently assessed studies for eligibility.ResultsWe screened 3154 separate titles and abstracts, and reviewed 16 full-texts. Corresponding authors were contacted to determine if samples met cachexia staging criteria. Most authors did not explore this concept. No trial met review eligibility criteria. We were unable to perform a meta-analysis to determine any effects from exercise intervention.ConclusionDespite a strong rationale for the use of exercise, there is insufficient evidence to determine safety and effectiveness in patients with cancer cachexia. Findings from ongoing studies are awaited. Assessment of cachexia domains, ideally against international criteria, is required for future trials of exercise and supportive care interventions.

show abstract

Exercise for cancer cachexia in adults

Cited by 12 publications

References 36 publications

Cancer cachexia: rationale for the MENAC (Multimodal—Exercise, Nutrition and Anti-inflammatory medication for Cachexia) trial

Cancer cachexia: rationale for the MENAC (Multimodal—Exercise, Nutrition and Anti-inflammatory medication for Cachexia) trial

Cancer-induced muscle wasting: latest findings in prevention and treatment

Exercise for cancer cachexia in adults: Executive summary of a Cochrane Collaboration systematic review

Contact Info

Product

Resources

About