Exercise effects on brain and behavior in healthy mice, Alzheimer’s disease and Parkinson’s disease model—A systematic review and meta-analysis

Daniele, Thiago Medeiros da Costa; Bruin, Pedro Felipe Carvalhedo de; Matos, Robson Salviano de; Bruin, Gabriela Sales de; Chaves, Cauby Maia

doi:10.1016/j.bbr.2020.112488

Cited by 38 publications

(16 citation statements)

References 95 publications

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“…Exercise-induced upregulation of Bdnf and its downstream physiological effects such as increased neural plasticity and associated improvements in learning and memory have been widely reported ( da Costa Daniele et al., 2020 ; Pedersen, 2019 ). To characterize the effect of exercise on our Bdnf -AS KO HO mice, two groups of Bdnf -AS KO HO and WT mice underwent acute involuntary exercise as per the timeline depicted in Figure- 3 A.…”

Section: Resultsmentioning

confidence: 99%

A novel knockout mouse model of the noncoding antisense Brain-Derived Neurotrophic Factor (Bdnf) gene displays increased endogenous Bdnf protein and improved memory function following exercise

Modarresi

Fatemi²,

Razavipour

et al. 2021

Heliyon

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Brain-derived neurotrophic factor (Bdnf ) expression is tightly controlled at the transcriptional and post-transcriptional levels. Previously, we showed that inhibition of noncoding Bdnf antisense ( Bdnf -AS) RNA upregulates Bdnf protein. Here, we generated a Bdnf -antisense knockout ( Bdnf- AS KO) mouse model by deleting 6 kilobases upstream of Bdnf -AS. After verifying suppression of Bdnf- AS, baseline behavioral tests indicated no significant difference in knockout and wild type mice, except for enhanced cognitive function in the knockout mice in the Y-maze. Following acute involuntary exercise, Bdnf -AS KO mice were re-assessed and a significant increase in Bdnf mRNA and protein were observed. Following long-term involuntary exercise, we observed a significant increase in nonspatial and spatial memory in novel object recognition and Barnes maze tests in young and aged Bdnf- AS KO mice. Our data provides evidence for the beneficial effects of endogenous Bdnf upregulation and the synergistic effect of Bdnf -AS knockout on exercise and memory retention.

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Section: Resultsmentioning

confidence: 99%

A novel knockout mouse model of the noncoding antisense Brain-Derived Neurotrophic Factor (Bdnf) gene displays increased endogenous Bdnf protein and improved memory function following exercise

Modarresi

Fatemi²,

Razavipour

et al. 2021

Heliyon

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“…In other words, intense locomotion can be used as a predictor of novelty and activate mechanisms of biological and cognitive "preadaptation" to less familiar environments 20,21 . Indeed, stimulating effects of running on the brain function in humans and rodents have been repeatedly demonstrated [22][23][24] . Decreased anxiety 25,26 , augmented neurogenesis 22,27,28 , improved memory and learning 22,27 , facilitation of decision-making 20,21,29 reported in numerous studies would be important or even crucial for surviving in the novel conditions.…”

Section: Discussionmentioning

confidence: 99%

Previous flight facilitates partner finding in female crickets

Mezheritskiy

Vorontsov

Lapshin

et al. 2020

Sci Rep

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In the cricket Gryllus bimaculatus, flying occurs soon after the last imaginal molt and precedes the mating behavior in natural conditions. Here, we tested the hypothesis that flying may improve subsequent behavioral performance in a novel environment in female crickets. We developed a behavioral set-up to test female cricket responsiveness to male calling song as well as their ability to locate and find the source of the song. The male song was produced by a loudspeaker hidden behind the fabric wall of a spacious square arena. Forced flight prior to the test promoted female sexual searching behavior in the novel environment. After the flight, more females reached the hidden source zone, spent more time near the source and finally more of them climbed over the wall section immediately in front of the hidden loudspeaker. At the same time, their behavior in the arena did not differ from the control group when the calling song was not delivered, suggesting that flight exerts its behavioral effects by influencing sexual motivation. Our results support the suggestion that preceding intense locomotion facilitates sexual searching behavior of females in a novel environment.

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“…Exercise has been shown to substantially increase BDNF levels in both rodents [69] and humans [70]. Studies are ongoing to determine whether exercise can improve disease outcomes by enhancing BDNF levels in the CNS.…”

Section: Brain-derived Neurotrophic Factormentioning

confidence: 99%

Intranasal Delivery: Effects on the Neuroimmune Axes and Treatment of Neuroinflammation

et al. 2020

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This review highlights the pre-clinical and clinical work performed to use intranasal delivery of various compounds from growth factors to stem cells to reduce neuroimmune interactions. We introduce the concept of intranasal (IN) delivery and the variations of this delivery method based on the model used (i.e., rodents, non-human primates, and humans). We summarize the literature available on IN delivery of growth factors, vitamins and metabolites, cytokines, immunosuppressants, exosomes, and lastly stem cells. We focus on the improvement of neuroimmune interactions, such as the activation of resident central nervous system (CNS) immune cells, expression or release of cytokines, and detrimental effects of signaling processes. We highlight common diseases that are linked to dysregulations in neuroimmune interactions, such as Alzheimer’s disease, Parkinson’s disease, stroke, multiple sclerosis, and traumatic brain injury.

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Exercise effects on brain and behavior in healthy mice, Alzheimer’s disease and Parkinson’s disease model—A systematic review and meta-analysis

Cited by 38 publications

References 95 publications

A novel knockout mouse model of the noncoding antisense Brain-Derived Neurotrophic Factor (Bdnf) gene displays increased endogenous Bdnf protein and improved memory function following exercise

A novel knockout mouse model of the noncoding antisense Brain-Derived Neurotrophic Factor (Bdnf) gene displays increased endogenous Bdnf protein and improved memory function following exercise

Previous flight facilitates partner finding in female crickets

Intranasal Delivery: Effects on the Neuroimmune Axes and Treatment of Neuroinflammation

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