Exercise during pregnancy increases hippocampal brain-derived neurotrophic factor mRNA expression and spatial learning in neonatal rat pup

Parnpiansil, P; Jutapakdeegul, Nuanchan; Chentanez, Thyon; Kotchabhakdi, Naiphinich

doi:10.1016/j.neulet.2003.08.023

Cited by 96 publications

(90 citation statements)

References 19 publications

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“…LPS treatment during critical stages of embryonic development has been shown to cause reduced adult hippocampal neurogenesis and BDNF levels, increased tendency of depressive behavior and long-term behavioral changes in adults [11]. Previously publish studies in the literature demonstrates an increased BDNF and VEGF levels in the brain and improved open field and locomotor activity test results from offspring of exercised mothers during pregnancy [5,9,[12][13][14]. Therefore, it is expected to observe an increased tolerance to the brain damage through endogenous trophic factors, such as BDNF.…”

Section: Discussionmentioning

confidence: 99%

Can gestational exercise have a positive effect on cognitive functions resulting from brain injury A rat study

Dilek

Orallar

Bozat

et al. 2018

j-ebr

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A B S T R A C T Aim:The effects of gestational exercise on potential pathological conditions is not known yet. Therefore, in the present study, it was aimed to evaluate the effects of forced running exercise on lipopolysaccharide (LPS)-induced brain damage in pregnant rats. Method: Pregnant females in the experimental group were forced to exercise 30 minutes daily for five days a week. Lipopolysaccharide (LPS)-induced brain injury model was created by administering 500 µg/kg body weight of LPS on gestational days 18 and 19. To evaluate injury histopathologically, brain tissues were fixed at the seventh postnatal day through transcardial perfusion (n=4 pups/group). When the remaining pups reached 30-day of age, Morris water maze test (MWM) was performed to assess memory and learning, open filed (OP) and elevated plus maze (EPM) for testing anxiety, and Porsolt test (PT) for evaluating depression. The groups were defined as brain injury group (BI, n=13) and exercise+brain injury group (E+BI, n=7). Results: The results obtained from MWM test indicated that animals found the platform in a shorter duration and distance at the day five compared to the day three. However, there was no significant difference between the groups. No significant difference was found in OP test regarding the distance traveled, time spent at the margins, movement at the center and the time spent as immobile. However, in the EPM test, the offspring at the BI group displayed higher mobility and increased number of entry to the open arms compared to the E+BI groups (p=0.01). There was no significant difference regarding mobility duration and total distance traveled in the PT test. Conclusion:The results of the EPM test suggests that the gestational exercise can suppress the stress factors in the pregnant females with brain injury leading to the prevention of hyperactivity-induced negative learning behavior.

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Section: Discussionmentioning

confidence: 99%

Can gestational exercise have a positive effect on cognitive functions resulting from brain injury A rat study

Dilek

Orallar

Bozat

et al. 2018

j-ebr

View full text Add to dashboard Cite

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“…The influence exerted by maternal enrichment during pregnancy on the fetus is not restricted to the visual system. The hippocampus of pups born from enriched mothers, indeed, displays increased expression of BDNF [88] and increased proliferation of progenitor cells in the granule layer [89], resulting in improved cognitive functions when the animals reach adult ages [90].…”

Section: Maternal Enrichment Effectsmentioning

confidence: 99%

Environmental Influences on Visual Cortex Development and Plasticity

Sale¹,

Berardi²,

Maffei³

2012

Visual Cortex - Current Status and Perspectives

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“…En este sentido existe evidencia de que el ejercicio físico de la madre puede inducir la sobreexpresión de genes en el hipocampo de ratas, lo cual se traduce en un aumento del aprendizaje espacial (Parnpiansil et al, 2003). Además, la natación de la madre rata durante el embarazo ha mostrado incrementar significativamente la expresión de mRNA del Factor Neurotrófico Derivado del Cerebro (BDNF), potenciar la neurogénesis hipocampal y mejorar la capacidad de memoria a corto plazo en su progenie (Lee at al, 2006).…”

Section: Herencia Epigenómicaunclassified

Influencia epigenómica de la actividad/inactividad física en el origen de la Diabetes mellitus tipo 2. (Epigenomic influence of the physical activity/inactivity in the origin of type 2 diabetes.)

Andrade¹,

Navarrete²

2009

rev. int. cienc. deporte

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Exercise during pregnancy increases hippocampal brain-derived neurotrophic factor mRNA expression and spatial learning in neonatal rat pup

Cited by 96 publications

References 19 publications

Can gestational exercise have a positive effect on cognitive functions resulting from brain injury A rat study

Can gestational exercise have a positive effect on cognitive functions resulting from brain injury A rat study

Environmental Influences on Visual Cortex Development and Plasticity

Influencia epigenómica de la actividad/inactividad física en el origen de la Diabetes mellitus tipo 2. (Epigenomic influence of the physical activity/inactivity in the origin of type 2 diabetes.)

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