Exercise-dependent growth hormone release is linked  to markers of heightened central adrenergic outflow

Weltman, Arthur; Pritzlaff, C. J.; Wideman, Laurie; Weltman, Judy Y.; Blumer, J L; Abbott, Robert D.; Hartman, Mark L.; Veldhuis, Johannes D.

doi:10.1152/jappl.2000.89.2.629

Cited by 48 publications

(31 citation statements)

References 41 publications

(50 reference statements)

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“…The effects of leptin modulating satiety are directly related to NO production. A decrease in food consumption induced by leptin infusion was mitigated by L-arginine infusion in chicken 23 . Ventricular intra-brain infusions of leptin promoted an expected suppression of food intake and reduction in nNOS activity; both effects are antagonized by L-arginine infusions 1 .…”

Section: Discussionmentioning

confidence: 91%

“…Previous studies showed that L-arginine may act on two fronts in these events, one goes through an amplified signal for the production of GH via stimulus in the anterior hypophysis 25 , and the other through an alternate route in the process of creatine formation and consequently resulting in a sarcoplasmic hypertrophy from increased fluid retention 26 and increased contractile filaments 23 .…”

Section: Recently Prodam Et Almentioning

confidence: 99%

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Acute hypothalamic administration of L-arginine increases feed intake in rats

et al. 2015

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ObjectiveThis study investigated the chronic (oral) and acute (hypothalamic infusion) effects of L-arginine supplementation on feed intake, body composition, and behavioral changes in rats. MethodsTwenty rats were divided into two groups treated orally for 60 days; one group received L-arginine (1 g/kg body weight) and one group received saline (1 mL/NaCl 0.9%). Daily consumption of water and food were evaluated, and weight monitored. After the oral treatment, the rats underwent stereotactic biopsy and a group was injected with 2 µL of L-arginine (0.5 mM) and another received an injection of saline (0.9% NaCl), in the hypothalamic route, through micro infusion. Immediately after micro infusion, the animal behavior was evaluated through tests in the open field. Food and water consumption were evaluated at 12 and 24 hours after the micro infusion. Daily water consumption and weight gain evolution were evaluated. At the end of treatments, rats were euthanized and blood was collected for glucose, glycerol, and cholesterol evaluation, and histological analysis of vital organs. ResultsOral supplementation with L-arginine increased water intake (11%, p<0.05) and promoted weight gain (3%, p<0.05). However, hypothalamic infusion promoted a significant increase in chow intake (30%, p<0.05) after 24 hours of L-arginine administration.

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Section: Discussionmentioning

confidence: 91%

Section: Recently Prodam Et Almentioning

confidence: 99%

Acute hypothalamic administration of L-arginine increases feed intake in rats

et al. 2015

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“…Impulses from motor centres directly stimulate both sympathoadrenal and pituitary secretion (Kjaer et al 1987). In addition, markers of central adrenergic outflow precede and are proportionate to increases in hGH after exercise (Weltman et al 2000). Endurance training reduces the plasma catecholamine response to a 30-s sprint (Brooks et al 1985), whilst the plasma catecholamine response to a 30-s sprint increases following sprint training (Nevill et al 1989).…”

Section: Discussionmentioning

confidence: 99%

Effect of 6�weeks of sprint training on growth hormone responses to sprinting

Stokes

Nevill

Cherry

et al. 2004

European Journal of Applied Physiology

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This study examined the effect of 6 weeks of prescribed sprint training on the human growth hormone (hGH) response to cycle ergometer sprinting. Sixteen male subjects were randomly assigned to a training (n=8) or a control (n=8) group. Each subject completed two main trials, consisting of two all-out 30-s cycle-ergometer sprints separated by 60 min of passive recovery, once before, and once after a 6-week training period. The training group completed three supervised sprint-training sessions per week in addition to their normal activity, whilst control subjects continued with their normal activity. In the training group, peak and mean power increased post-training by 6% (P<0.05) and 5% (P<0.05), respectively. Post-exercise blood pH did not change following training, but the highest post-exercise blood lactate concentrations were greater [highest measured value: 13.3 (1.0) vs 15.0 (1.1) mmol l(-1)], with lower blood lactate concentrations for the remainder of the recovery period (P<0.05). Post-exercise plasma ammonia concentrations were lower after training [mean highest measured value: 184.1 (9.8) vs 139.0 (11.7) micromol l(-1), P<0.05]. Resting serum hGH concentrations did not change following training, but the peak values measured post-exercise decreased by over 40% in the training group [10.3 (3.1) vs 5.8 (2.5) microg l(-1), P<0.05], and mean integrated serum hGH concentrations were 55% lower after training [567 (158) vs 256 (121) min microg l(-1), P<0.05]. The hGH response to the second sprint was attenuated similarly before and after training. This study showed that 6 weeks of combined speed- and speed-endurance training blunted the human growth hormone response to sprint exercise, despite an improvement in sprint performance.

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“…The actions of GH and testosterone are enhanced by catecholamines, which reflect the acute demands of exercise, and influence force production, muscle contraction rate and energy availability [65][66][67]. Research has reported low-intensity resistance exercise with BFR to increase norepinephrine secretion, in concert with GH and lactate levels, more than without BFR [8,18].…”

Section: Hormonal Responsesmentioning

confidence: 99%

Hypoxia and Resistance Exercise: A Comparison of Localized and Systemic Methods

et al. 2014

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It is generally believed that optimal hypertrophic and strength gains are induced through moderate-or high-intensity resistance training, equivalent at least 60% of an individual's 1-repetition maximum (1RM). However, recent evidence suggests that similar adaptations are facilitated when low-intensity resistance exercise (~20-50% 1RM) is combined with blood flow restriction (BFR) to the working muscles. Although the mechanisms underpinning these responses are not yet firmly established, it appears that localized hypoxia created by BFR may provide an anabolic stimulus by enhancing the metabolic and endocrine response, and increase cellular swelling and signalling function following resistance exercise. Moreover, BFR has also been demonstrated to increase type II muscle fibre recruitment during exercise.However, inappropriate implementation of BFR can result in detrimental effects, including petechial haemorrhage and dizziness. Further, as BFR is limited to the limbs, the muscles of the trunk are unable to be trained under localized hypoxia. More recently, the use of systemic hypoxia via hypoxic chambers and devices has been investigated as a novel way to stimulate similar physiological responses to resistance training as BFR techniques. While little evidence is available, reports indicate that beneficial adaptations, similar to those induced by BFR, are possible using these methods. The use of systemic hypoxia allows large groups to train concurrently within a hypoxic chamber using multi-joint exercises. However, further scientific research is required to fully understand the mechanisms that cause augmented muscular changes during resistance exercise with a localized or systemic hypoxic stimulus.3

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Exercise-dependent growth hormone release is linked to markers of heightened central adrenergic outflow

Cited by 48 publications

References 41 publications

Acute hypothalamic administration of L-arginine increases feed intake in rats

Acute hypothalamic administration of L-arginine increases feed intake in rats

Effect of 6�weeks of sprint training on growth hormone responses to sprinting

Hypoxia and Resistance Exercise: A Comparison of Localized and Systemic Methods

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