Exercise causes blood glutathione oxidation in chronic obstructive pulmonary disease: prevention by O₂ therapy

Abstract

Viña, José, Emilio Servera, Miguel Asensi, Juan Sastre, Federico V. Pallardó, José A. Ferrero, JoséGarcı́a-de-la-Asunción, Vicente Antón, and Julio Marı́n. Exercise causes blood glutathione oxidation in chronic obstructive pulmonary disease: prevention by O2therapy. J. Appl. Physiol. 81(5): 2199–2202, 1996.—The aim of the present study was to determine whether glutathione oxidation occurs in chronic obstructive pulmonary disease (COPD) patients who perform exercise and whether this could be prevented. Blood glutathione red-ox ratio [oxidized-to-reduced glutathione (GSSG/GSH)] was significantly increased when patients performed exercise for a short period of time until exhaustion. Their resting blood GSSG/GSH was 0.039 ± 0.008 (SD) ( n = 5), whereas after exercise it increased to 0.085 ± 0.019, P < 0.01. Glutathione oxidation associated with exercise was partially prevented by oxygen therapy (resting value: 0.037 ± 0.014, n = 5; after exercise: 0.047 ± 0.016, n = 5, P < 0.01). We conclude that light exercise causes an oxidation of glutathione in COPD patients, which can be partially prevented by oxygen therapy.

Free Radicals in Exhaustive Physical Exercise: Mechanism of Production, and Protection by Antioxidants

“…These patients are exhausted when they perform light exercise of the kind that is required to carry out daily activities. Figure 2 shows that a light exercise can be exhaustive for COPD patients, causing an oxidation of glutathione in blood (8). Figure 3 shows that malondialdehyde is increased in COPD patients after exercise (8).…”

Vitamin C supplementation influences the antioxidant response and nitric oxide handling of erythrocytes and lymphocytes to diving apnea

“…Many 'in vitro' studies have been carried out on hypoxiareoxygenation; however, there are few 'in vivo' human studies about the effects of the hypoxic conditions on the cellular antioxidant defences (Vina et al, 1996;Vento et al, 2003). Exercise in chronic obstructive pulmonary disease (COPD) patients is a hypoxic situation because there is a lack of oxygen relative to the metabolic needs.…”

“…Exercise in chronic obstructive pulmonary disease (COPD) patients is a hypoxic situation because there is a lack of oxygen relative to the metabolic needs. Exercise in these patients causes glutathione oxidation, which can be partially prevented by oxygen therapy (Vina et al, 1996). In a previous study, we used exercise in diving apnea as a model of repetitive hypoxia-reoxygenation situation (Sureda et al, 2004a, b).…”

Skeletal muscle dysfunction and oxidative stress in patients with chronic obstructive lung disease

“…Vina et al 14) first reported the impact of acute exercise on oxidative stress in COPD patients. That study found increases in oxidized glutathione (GSSG) and reduced glutathione (GSH) ratio (GSSG/GSH) after COPD patients performed cycle ergometry at a similar intensity to normal activities of daily living [approximately three metabolic equivalents (METS)] until exhaustion.…”

“…However, the main component of pulmonary rehabilitation is physical exercise, and physical exercise is known to impose oxidative stress on the body by increased generation of reactive oxygen species (ROS), particularly the superoxide anion *Correspondence: oshuji@ad.cyberhome.ne.jp (O2 -) [11][12][13] . In patients with COPD, short periods of exercise can induce systemic oxidative stress 14) , suggesting that even activities of daily living could cause oxidative stress. In the current review, we will attempt to briefly summarize the pathophysiology of skeletal muscle dysfunction in COPD patients, focusing on oxidative stress and inflammation.…”