Exercise capacity in patients with cystic fibrosis vs non-cystic fibrosis bronchiectasis

Abstract

Background Bronchiectasis is associated with morbidity, low exercise capacity and poor quality of life. There is a paucity of data on exercise capacity using cardiopulmonary exercise test (CPET) in non-cystic fibrosis (CF) bronchiectasis. Our aim was to compare exercise capacity using CPET in CF and non-CF bronchiectasis patients. Methods Cross-sectional retrospective/prospective controlled study assessing CPET using cycle ergometer. Exercise parameters and computed tomography (CT) findings were compared. Results: Hundred two patients with bronchiectasis and 88 controls were evaluated; 49 CF (age 19.7 ± 9.7 y/o, FEV 1 %predicted 70.9 ± 20.5%) and 53 non-CF (18.6 ± 10.6 y/o, FEV 1 % predicted 68.7 ± 21.5%). Peak oxygen uptake (peak _ VO 2) was similar and relatively preserved in both groups (CF 1915.5±702.0; non-CF 1740±568; control 2111.0±748.3 mL/min). Breathing limitation was found in the two groups vs. control; low breathing reserve (49% in CF; 43% non-CF; 5% control) and increased _ VE= _ VCO 2 (CF 31.4±4.1, non-CF 31.7±4.1 and control 27.2 ± 2.8). Oxygen pulse was lower in the non-CF; whereas a linear relationship between peak _ VO 2 vs. FEV 1 and vs. FVC was found only for CF. CT score correlated with _ VE= _ VCO 2 and negatively correlated with _ VO 2 =kg and post exercise oxygen saturation (SpO 2). Conclusions CPET parameters may differ between CF and non-CF bronchiectasis. However, normal exercise capacity may be found unrelated to the etiology of the bronchiectasis. Anatomical

Effect of Trikafta on bone density, body composition and exercise capacity in CF: A pilot study

“…VE/VCO 2 is a submaximal marker for ventilatory drive, that is related to the amount and sensitivity of central chemoreceptors and the ventilatory dead space. A previous study in our institute found a correlation between computed tomography (CT) scores and VE/VCO 2 29 . In a study evaluating longitudinal changes in exercise capacity in adult CF patients, VE/VCO 2 at anaerobic threshold was higher ( p = 0.047) and the ventilatory reserve by the end of the exercise was lower ( p = 0.019) during follow‐up 34 .…”

“…Exercise capacity is a biomarker of whole body metabolic performance, and is associated with lung function trajectories and quality of life in CF 29,30 . Oxygen uptake, exercise duration and workload measured by CPET have been found as useful prognostic indicators for survival in CF 28 .…”