Exercise, cancer and the immune response of monocytes.

Peters, Christiane; Lötzerich, H.; Niemeir, B; Schüle, Klaus; Uhlenbruck, G

doi:10.1097/01893697-199715030-00026

Cited by 31 publications

(64 citation statements)

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“…It has been postulated that increased sympathetic nervous system activity leads to both higher heart rate and other physiologic factors (Palatini 1999). The risk of cancer mortality has also been found in many studies to be greater among subjects with higher resting heart rates, although there are few postulated mechanisms to explain why (Garcia-Palmieri et al 1981;Wannamethee et al 1993;Gann et al 1995;Peters et al 1995;Thomas et al 2001). Singh et al (1999) have reported that heredity is a substantial determinant of resting heart rate, and a gene affecting heart rate has been found in the spontaneously hypertensive rat (Kreutz et al 1997).…”

Section: Introductionmentioning

confidence: 91%

Evidence for a gene influencing heart rate on chromosome 4 among hypertensives

et al. 2002

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While mechanisms are poorly understood, resting heart rate has been shown to be a strong predictor of the risk of cardiovascular disease, cancer, and all-cause mortality. We performed a genome scan for quantitative trait loci influencing the resting heart rate among 962 Caucasians and 1,124 African-Americans in the Hypertension Genetic Epidemiology Network (HyperGEN), a multi-center study of genetic and environmental factors related to hypertension. The NHLBI Mammalian Genotyping Service typed a total of 391 anonymous microsatellite markers, spaced roughly equally throughout the genome. Within each race and sex, heart rate was adjusted for covariates, including age, age(2), study center, body mass index, beta-blocker use, alcohol consumption, smoking, number of city blocks walked per day, and number of hours watching television. Genome scans were performed using variance component linkage analysis as implemented by GENEHUNTER (version 2) for each race, using race-specific marker allele frequencies derived from random samples. The highest lod score detected in Caucasians was 2.14 on chromosome 4 (at 195.06 cM); a lod score of 1.14 was found at the same locus among the African-Americans, and a lod score of 3.18 resulted when the two racial groups were combined. Evidence was also found on chromosome 10 to support a recent report of an association between heart rate and the beta1 adrenergic receptor. The suggestive evidence for linkage found on chromosome 4 in both Caucasian and African-American hypertensive sib pairs indicates that further investigation on that region may be warranted to locate a gene influencing variability in resting heart rate.

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Section: Introductionmentioning

confidence: 91%

Evidence for a gene influencing heart rate on chromosome 4 among hypertensives

et al. 2002

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“…Overall, six studies were found that met the inclusion criteria 36–41. These studies were published between 1994 and 2000 and all appeared as research articles.…”

Section: Immune System Response To Tumorsmentioning

confidence: 99%

“…The purposes of the six studies were similar. All six studies examined the effect of physical exercise training on immune system function in cancer survivors during or after cancer treatment 36–41. For example, two studies examined the effect of physical exercise training on NK cell cytolytic activity in breast carcinoma survivors 38, 40.…”

Section: Immune System Response To Tumorsmentioning

confidence: 99%

Physical exercise and immune system function in cancer survivors

Fairey

Courneya

Field

et al. 2002

Cancer

139

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BACKGROUNDThere are a limited number of interventions for cancer survivors following completion of primary therapy that might reduce the risk of cancer recurrence and/or secondary malignancies and increase survival times. It has been proposed that physical exercise may be beneficial by enhancing the anticancer immune system response. The purpose of the current article is to: 1) briefly describe the immune system response to tumors, 2) discuss the impact of anticancer therapy on immune system function in cancer survivors, 3) provide a systematic and comprehensive review of the extant literature examining physical exercise and immune system function in cancer survivors, and 4) offer a critical analysis of this literature and outline directions for future research.METHODSA comprehensive literature search up to March 2001 identified empirical articles that examined the effects of physical exercise training on immune system function in cancer survivors from CD‐ROM database searches and manual searches.RESULTSTo the authors' knowledge, six empirical studies published between 1994 and 2000 have examined physical exercise and immune system function in cancer survivors. Overall, four out of six studies reported statistically significant improvements in a number of cancer‐related immune system components as a result of exercise. However, there are several limitations that must be considered when interpreting the findings of these studies. These limitations involve the samples, designs, physical exercise interventions, physical fitness assessments, and immunologic assessments.CONCLUSIONSAdditional research is needed to determine if physical exercise in cancer survivors may reduce the risk of cancer recurrence and secondary malignancies and increase survival times. Cancer 2002;94:539–51. © 2002 American Cancer Society.

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“…Recent studies show that low-dose computer tomography scan can be used to screen lung cancer effectively and reduce its mortality (Aberle and Brown, 2008;Coche, 2008). Secondly, comprehensive interventions including psychological intervention, dietary guidance and exercise intervention are required (Peters et al, 1995;Cunningham et al, 1998;Glare et al, 2008). Thirdly, self-management educations should be promoted for patients to improve compliance and effectiveness of the treatment, to develop good habits and to alleviate the pressure.…”

Section: Discussionmentioning

confidence: 99%