Exercise behavior and patient-reported outcomes in women with early breast cancer receiving locoregional radiation therapy

Arya, Ritu; Siamakpour-Reihani, Sharareh; Palta, Manisha; Massa, Lisa; Broadwater, Gloria; Blitzblau, Rachel; Horton, Janet K.

doi:10.1016/j.prro.2015.01.003

Cited by 6 publications

(4 citation statements)

References 23 publications

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“…After behavioral modifica-tion and assessment of sleep hygiene, depending on performance status, we recommend daily mild to moderate physical activity to manage sleep cycle regulation prior to initiating pharmacotherapy. Combating fatigue with exercise has been most thoroughly described in breast cancer patients [48,49], with a mechanism of action thought to be due to downregulation of cytokines [50]. Although other disease sites may see improvement in these side effects with adoption of hypofractionation, retroperitoneal sarcoma treatment regimens commonly involve at least 5 weeks of therapy due to the proximity to organs at risk (e.g.…”

Section: Discussionmentioning

confidence: 99%

Using the revised Edmonton symptom assessment scale during neoadjuvant radiotherapy for retroperitoneal sarcoma

Palm

Jim

Boulware

et al. 2020

Clinical and Translational Radiation Oncology

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Background and purpose: Retroperitoneal sarcoma (RPS) is a rare, complex disease requiring multidisciplinary management. We have previously reported that use of the Revised Edmonton Symptom Assessment Scale (ESAS-r-CSS) allows for proactive symptom management, and we sought to report the results of ESAS-r-CSS screening during pre-operative radiotherapy (RT) for a cadre of patients with RPS. Materials and methods: We reviewed records of 47 patients with RPS evaluated at our institution between 2015 and 2018. Of this group, 29 non-metastatic patients were treated with definitive intent neoadjuvant RT with at least 2 weekly ESAS-r-CSS reports. A generalized estimating equation model was used to compare 13 symptoms during weekly on-treatment visits compared to baseline scores at week 1 of RT. Additionally, covariate effects of age, gender, dose, tumor size and location were assessed. Results: The population was predominantly male (66%) with median age of 65 years, KPS of 90, and tumor size of 12.8 cm. ESAS scores significantly decreased for anxiety at week 3 (P = 0.01), and pain at week 5 (P = 0.01). Worse constipation was reported at week 2 (P = 0.02). In an exploratory covariate analysis, female gender, age, high dose, and larger tumor size were associated with worse ESAS scores across all time points. Conclusion: Patient reporting of symptoms during radiotherapy through weekly ESAS-r-CSS facilitates timely management in patients with this unique tumor type. Expectant care during RT offers the opportunity to minimize symptom progression or treatment interruptions in a population that generally has worsening side effects.

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Section: Discussionmentioning

confidence: 99%

Using the revised Edmonton symptom assessment scale during neoadjuvant radiotherapy for retroperitoneal sarcoma

Palm

Jim

Boulware

et al. 2020

Clinical and Translational Radiation Oncology

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“…However, they also reported that increasing the diversity of physical activities was of great importance because this may create alternative exercise options in the treatment of lymphedema. It has been reported that different exercise models, group exercise, social activity-oriented exercises, and Pilates training might be useful in patients with lymphedema (19,20,22,24,26).…”

Section: Discussionmentioning

confidence: 99%

“…The flow rate of the lymphatic fluid throughout the body depends on the intermittent external pressure by skeletal muscles. Therefore, researchers emphasize that the treatment of a patient with lymphedema should include the reactivation of the patient's arm functions and also the exercises that activate the whole body (18)(19)(20)(21).…”

Section: Effects Of Clinical Pilates Exercises On Patients Developingmentioning

confidence: 99%

Effects of Clinical Pilates Exercises on Patients Developing Lymphedema after Breast Cancer Treatment: A Randomized Clinical Trial

Şener¹,

Malkoç²,

Ergin³

et al. 2017

J Breasth Health

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Objective: The aim of the present study was to compare the effects of clinical Pilates exercises with those of the standard lymphedema exercises on lymphedema developing after breast cancer treatment. Materials and Methods:The study comprised 60 female patients with a mean age of 53.2±7.7 years who developed lymphedema after having breast cancer treatment. The patients were randomized into two groups: the clinical Pilates exercise group (n=30), and the control group (n=30). Before, and at the 8th week of treatment, the following parameters were measured: the severity of lymphedema, limb circumferences, body image using the Social Appearance Anxiety Scale, quality of life with the European Organization for Research and Treatment of Cancer (EORTC) quality of life questionnaire (QLQ-BR23), and upper extremity function using the Disabilities of the Arm, Shoulder and Hand (DASH) outcome measure. Both groups performed one-hour exercises three days a week for 8 weeks.Results: After treatment, the symptoms recovered significantly in both groups. Reductions in the severity of lymphedema, improvements in the social appearance anxiety scale scores, quality of life scores, and upper extremity functions scores in the clinical Pilates exercise group were greater than those in the control group. Clinical Pilates exercises were determined to be more effective on the symptoms of patients with lymphedema than were standard lymphedema exercises. Conclusions:Clinical Pilates exercises could be considered a safe model and would contribute to treatment programs.

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“…Given its frequency and adverse consequences, early interventions to mitigate the effects of radiation-induced fatigue have been proposed, including exercise programs (3,16). To efficiently deploy these interventions and counsel patients, predictors of fatigue must be identified.…”

Section: Introductionmentioning

confidence: 99%

Clinical Indicators of Psychosocial Distress Predict for Acute Radiation-Induced Fatigue in Patients Receiving Adjuvant Radiation Therapy for Breast Cancer: An Analysis of Patient-Reported Outcomes

Kishan

Wang

Sharif

et al. 2016

International Journal of Radiation Oncology*Biology*Physics

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Exercise behavior and patient-reported outcomes in women with early breast cancer receiving locoregional radiation therapy

Cited by 6 publications

References 23 publications

Using the revised Edmonton symptom assessment scale during neoadjuvant radiotherapy for retroperitoneal sarcoma

Using the revised Edmonton symptom assessment scale during neoadjuvant radiotherapy for retroperitoneal sarcoma

Effects of Clinical Pilates Exercises on Patients Developing Lymphedema after Breast Cancer Treatment: A Randomized Clinical Trial

Clinical Indicators of Psychosocial Distress Predict for Acute Radiation-Induced Fatigue in Patients Receiving Adjuvant Radiation Therapy for Breast Cancer: An Analysis of Patient-Reported Outcomes

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