Exercise-based rehabilitation for cancer survivors with chemotherapy-induced peripheral neuropathy

McCrary, J. Matt; Goldstein, David; Sandler, Carolina X.; Barry, Benjamin K.; Marthick, Michael; Timmins, Hannah C.; Li, Tiffany; Horvath, Lisa G.; Grimison, Peter; Park, Susanna B.

doi:10.1007/s00520-019-04680-w

Cited by 59 publications

(91 citation statements)

References 39 publications

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“…Studies were identified that assessed the following selfinitiated strategies: massage and hot baths (within a single study [59]), meditation [60,62,63], exercise [61,[64][65][66][67][68], and TENS [69][70][71][72][73][74]. The TENS interventions were included because in some settings this treatment is initiated by patients themselves (i.e., TENS machines are available for purchase over the counter in the United States [US], some European countries, and Australia).…”

Section: Description Of Studiesmentioning

confidence: 99%

“…Two of the studies involved nonrandomized allocation to intervention and control groups [59,65]. The remaining five studies employed a pre-and post-test design [61,64,67,68,72]. The 16 studies included a total of 549 patients, with sample sizes ranging from 14 [61] to 66 [66].…”

Section: Description Of Studiesmentioning

confidence: 99%

“…Seven of the 16 studies measured PN symptoms pre-and postintervention, using seven different instruments [64,[66][67][68][72][73][74]. Detailed results for PN-associated symptom and impairment measures and outcomes are included in Table 2.…”

Section: Self-reported Pn-associated Symptoms and Impairmentmentioning

confidence: 99%

“…Eight of the 16 studies (massage/foot bath, meditation, and exercise) assessed quality of life using seven different measures [59,60,62,63,[65][66][67][68]. Detailed results for PNassociated quality of life measures and outcomes are included in Table 4.…”

Section: Quality Of Lifementioning

confidence: 99%

“…McCrary et al [68], Ruhland and Shields [65], and Ahn and Song [67] used the 36-Item Short Form Health Survey to measure a range of health dimensions associated with quality of life [65,67]. McCrary et al reported a significant improvement in mean quality of life scores for the exercise intervention instrument overall [68]. Ruhland and Shields reported significant improvement within the role limitation (physical) dimension of the instrument for the exercise group compared to the control group [65].…”

Section: Quality Of Lifementioning

confidence: 99%

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Systematic review of the effectiveness of self-initiated interventions to decrease pain and sensory disturbances associated with peripheral neuropathy

et al. 2020

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Purpose A small number of studies report that patients with peripheral neuropathy (PN) who engage in activities that promote a sense of personal well-being and provide physical, emotional, or spiritual comfort have a better quality of life and higher levels of adjustment to the changes generated by their illness and accompanying symptoms. This systematic review sought to evaluate the effectiveness of self-management activities that patients with PN initiate themselves to relieve PN symptoms and improve quality of life. Methods Search terms were limited to include self-management activities initiated by patients (i.e., activities with no or minimal involvement from clinicians) that aim to provide relief of PN symptoms. Outcomes included in searches were pain, numbness, and tingling, associated with PN and quality of life. Results The database searches identified 2979 records, of which 1620 were duplicates. A total of 1322 papers were excluded on the basis of screening the abstract. An additional 21 full text articles were excluded because they did not meet the eligibility criteria. A total of 16 papers were included in the review. Conclusion This review identified that a number of self-management strategies that were initiated by patients, including heat, exercise, meditation, and transcutaneous electrical nerve stimulation (TENS) therapy, may reduce self-reported PN symptoms. As the available studies were of low quality, these strategies warrant further investigation with more homogeneous samples, using more rigorously designed trials and larger samples. Implications for Cancer Survivors Patients experiencing PN may find a range of self-initiated strategies beneficial in reducing PN symptoms and improving quality of life. However, because of the low quality of the available studies, clinicians need to monitor patients' responses to determine the effectiveness of these interventions as adjuncts to clinician-initiated interventions.

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Section: Description Of Studiesmentioning

confidence: 99%

Section: Description Of Studiesmentioning

confidence: 99%

Section: Self-reported Pn-associated Symptoms and Impairmentmentioning

confidence: 99%

Section: Quality Of Lifementioning

confidence: 99%

Section: Quality Of Lifementioning

confidence: 99%

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Systematic review of the effectiveness of self-initiated interventions to decrease pain and sensory disturbances associated with peripheral neuropathy

et al. 2020

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Type of exercise may influence postural adaptations in chemotherapy‐induced peripheral neuropathy

Kneis

Wehrle

Müller

et al. 2021

Ann Clin Transl Neurol

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Objective Traditional posturography measurements characterize postural instability in patients with chemotherapy‐induced peripheral neuropathy (CIPN), while underlying postural control mechanisms remain unclear. Taking a model‐based approach can yield insights into these mechanisms. This study’s aim was to characterize the modifications in postural control of CIPN patients associated with exercise in relation to the postural behavior of healthy control participants (hCON) via an exploratory approach. Methods Thirty‐one CIPN patients were randomly assigned to two interventions (balance plus moderate endurance training vs. moderate endurance training only) and exercised twice per week over 12 weeks. Baseline data were compared to 36 matched hCONs. We recorded spontaneous sway and postural reactions to platform tilts using Optotrak and a Kistler force platform pre‐ and post‐intervention. Data interpretation relied on a model‐based parameter identification procedure. Results Spontaneous sway amplitudes were larger and postural reactions smaller, with a relative phase advance, in our pre‐intervention patients than the hCONs. Post‐intervention, spontaneous sway, and postural reactions were reduced and the sensory‐motor ratio larger in both groups, while the postural reaction timing differed between groups. Interpretation The abnormally small postural reactions in CIPN patients before the intervention can be interpreted as the consequence of abnormally strong velocity control—a strategy modification that may serve as a prediction mechanism to compensate for the lack of timely and accurate proprioceptive signals. While both groups reduced postural sway and showed an adapted sensory‐motor ratio post‐intervention, the interventions seemed to trigger different velocity control strategies. This study emphasizes the need for taking a more differentiated perspective on intervention effects. Trial registration German Clinical Trials Register (DRKS) number: DRKS00005419, prospectively registered on November 19, 2013.

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Approaches to opioid prescribing in cancer survivors: Lessons learned from the general literature

Jones

Merlin

2021

Cancer

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Exercise-based rehabilitation for cancer survivors with chemotherapy-induced peripheral neuropathy

Cited by 59 publications

References 39 publications

Systematic review of the effectiveness of self-initiated interventions to decrease pain and sensory disturbances associated with peripheral neuropathy

Systematic review of the effectiveness of self-initiated interventions to decrease pain and sensory disturbances associated with peripheral neuropathy

Type of exercise may influence postural adaptations in chemotherapy‐induced peripheral neuropathy

Approaches to opioid prescribing in cancer survivors: Lessons learned from the general literature

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