Exercise and taurine in inflammation, cognition, and peripheral markers of blood-brain barrier integrity in older women

Chupel, Matheus Uba; Minuzzi, Luciéle Guerra; Furtado, Guilherme Eustáquio; Santos, M.L.A.S.; Hogervorst, Eef; Filaire, Edith; Teixeira, Ana Maria

doi:10.1139/apnm-2017-0775

Cited by 54 publications

(37 citation statements)

References 51 publications

(52 reference statements)

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“…37 Another explanation for the different results of cortical thickness between the two groups is the protective effects of exercise on neurovascular function. Exercise significantly improved blood brain barrier integrity in elderly women, 38 and exercise significantly increased endothelial function and cerebral blood flow, which can prevent neuronal hypoxia and degeneration. 39,40 Meanwhile, many of the regions that showed reduced cortical thickness in Non-Exercise group are components of default mode network (DMN), encompassing posterior cingulate cortex, precuneus, medial prefrontal cortex, mesial and inferior temporal cortex and inferior parietal cortex.…”

Section: Discussionmentioning

confidence: 97%

Effects of Moderate Intensity Exercise on the Cortical Thickness and Subcortical Volumes of Preclinical Alzheimer’s Disease Patients: A Pilot Study

Wang

Kim

et al. 2020

Psychiatry Investig

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Objective We aimed to explore the impact of moderate intensity exercise on the cortical thickness and subcortical volumes of preclinical Alzheimer’s disease (AD) patients.Methods Sixty-three preclinical AD patients with magnetic resonance imaging (MRI) and 18-florbetaben positron emission tomography (PET) data were enrolled in the study. Information on demographic characteristics, cognitive battery scores, self-reported exercise habits were attained. Structural magnetic resonance images were analyzed and processed using Freesurfer v6.0.Results Compared to Exercise group, Non-Exercise group demonstrated reduced cortical thickness in left parstriangularis, rostral middle frontal, entorhinal, superior frontal, lingual, superior parietal, lateral occipital, inferior parietal gyrus, temporal pole, precuneus, insula, fusiform gyrus, right precuneus, superiorparietal, lateral orbitofrontal, rostral middle frontal, medial orbitofrontal, superior frontal, lingual, middle temporal gyrus, insula, supramarginal, parahippocampal, paracentral gyrus. Volumes of right thalamus, caudate, putamen, pallidum, hippocampus, amygdala were also reduced in Non-Exercise group.Conclusion Moderate intensity exercise affects cortical and subcortical structures in preclinical AD patients. Thus, physical exercise has a potential to be an effective intervention to prevent future cognitive decline in those at high risk of AD.

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Section: Discussionmentioning

confidence: 97%

Effects of Moderate Intensity Exercise on the Cortical Thickness and Subcortical Volumes of Preclinical Alzheimer’s Disease Patients: A Pilot Study

Wang

Kim

et al. 2020

Psychiatry Investig

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“…A recent study by Chupel et al [67] showed that physical exercise can maintain BBB integrity. The anti-inflammatory effect of combined exercise training and taurine supplementation on peripheral markers of BBB integrity, inflammation and cognition in 48 elderly women was investigated.…”

Section: Exercise and Systemic Inflammationmentioning

confidence: 99%

Blood-brain barrier permeability and physical exercise

Małkiewicz

Szarmach

Sabisz

et al. 2019

J Neuroinflammation

158

113

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In this narrative review, a theoretical framework on the crosstalk between physical exercise and blood-brain barrier (BBB) permeability is presented. We discuss the influence of physical activity on the factors affecting BBB permeability such as systemic inflammation, the brain renin-angiotensin and noradrenergic systems, central autonomic function and the kynurenine pathway. The positive role of exercise in multiple sclerosis and Alzheimer’s disease is described. Finally, the potential role of conditioning as well as the effect of exercise on BBB tight junctions is outlined. There is a body of evidence that regular physical exercise diminishes BBB permeability as it reinforces antioxidative capacity, reduces oxidative stress and has anti-inflammatory effects. It improves endothelial function and might increase the density of brain capillaries. Thus, physical training can be emphasised as a component of prevention programs developed for patients to minimise the risk of the onset of neuroinflammatory diseases as well as an augmentation of existing treatment. Unfortunately, despite a sound theoretical background, it remains unclear as to whether exercise training is effective in modulating BBB permeability in several specific diseases. Further research is needed as the impact of exercise is yet to be fully elucidated.

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“…3 It is found in the cytoplasm and dendrites of neurons and neuroendocrine cells, 3 in the case of brain damage due to increased blood-brain barrier (BBB) permeability and neurodegeneration concentration of NSE in blood serum arise. 4 Elevated NSE usually reflects the severity of the dysfunction of the BBB and possesses a high predictive value for the occurrence of cerebral ischemic stroke. 5 The highest concentration of NSE was observed 4-8 hours after brain damage and was directly proportional to the severity of neuronal damage.…”

Section: Introductionmentioning

confidence: 99%

Neuron- specific enolase level in patients with metabolic syndrome and its value forecasting acute stroke

Ospanov¹,

Ospanova²,

Kadyrova³

2018

AMJ

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RESEARCHPlease cite this paper as: Ospanov O, Ospanova K, Kadyrova I. Neuron-specific enolase level in patients with metabolic syndrome and its value forecasting acute stroke. AMJ 2018;11(3):186-194. ABSTRACT BackgroundPatients with metabolic syndrome are at a greater risk of experiencing a cerebrovascular event. Several studies show that patients with metabolic syndrome have asymptomatic ischemic brain injury. In this case, there is a need for rapid determination of asymptomatic brain lesions and prediction of acute stroke. AimsThe aim of the study was to determine the neuron-specific enolase (NSE) serum level in patients with metabolic syndrome and the value of this level for forecasting acute stroke. MethodsThe study used the following information to determine metabolic syndrome: waist circumference, total cholesterol, triglycerides, high-density lipoprotein cholesterol, blood pressure, and blood glucose. Doppler sonography mapping of the brachiocephalic trunk was held to determine the percentage of the carotid artery stenosis. To determine asymptomatic ischemic brain injury, the NSE serum marker was measured. Statistical processing of the measurements was performed using the H test and the Mann-Whitney test. The possible link between MS and NSE were determined by logistic regression analysis. Mathematical modeling was performed using logistic regression. ResultsThere are statistically significant differences in NSE concentrations in groups with metabolic syndrome and ischemic stroke patients. This assertion is confirmed by logistic regression analysis, which revealed the existence of a relationship between metabolic syndrome and increased concentration of NSE. ConclusionPatients with metabolic syndrome have an increased concentration of NSE. This indicates the presence of asymptomatic ischemic neuronal damage. A prognostic model for determining the probability that patients with metabolic syndrome will have an acute stroke was developed.

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Exercise and taurine in inflammation, cognition, and peripheral markers of blood-brain barrier integrity in older women

Cited by 54 publications

References 51 publications

Effects of Moderate Intensity Exercise on the Cortical Thickness and Subcortical Volumes of Preclinical Alzheimer’s Disease Patients: A Pilot Study

Effects of Moderate Intensity Exercise on the Cortical Thickness and Subcortical Volumes of Preclinical Alzheimer’s Disease Patients: A Pilot Study

Blood-brain barrier permeability and physical exercise

Neuron- specific enolase level in patients with metabolic syndrome and its value forecasting acute stroke

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