Exercise and Physical Activity in the Prevention and Treatment of Atherosclerotic Cardiovascular Disease

Regular treadmill exercise restores cardioprotective signaling pathways in obese mice independently from improvement in associated co-morbidities

“…Areas at risk were placed in medium containing 220 mM mannitol, 70 mM sucrose, 10 mM HEPES, 1 mM EGTA, 5µl/ml of protease inhibitor cocktail, 1 mM sodium orthovanadate, 5 mM sodium fluoride, 1 mM sodium Na 2 (Santa Cruz Biotechnology, Santa Cruz, CA, USA). Blots were finally incubated using the ECL detection system (Pierce, Rockford, IL, USA) and exposed to ECL chemiluminescence film (Hyperfilm ECL, Amersham, Buckinghamshire, UK).…”

“…Consequently, several strategies, pharmacological or not, have been proposed to induce cardioprotection. Among them, regular exercise has been shown to reduce cardiovascular morbi-mortality [1,2] and is considered as the only practical and sustainable countermeasure capable of providing cardioprotection against myocardial infarction. Interestingly, clinical investigations have demonstrated that exercise is a cardioprotective factor, independent of the presence of other risk factors [3][4][5].…”

Is the Environment Near Home and School Associated with Physical Activity and Adiposity of Urban Preschool Children?

“…Strategies to promote childhood physical activity are becoming a public health priority, 1,2 both because an active lifestyle has direct health benefits, [3][4][5][6] and because physical activity plays a role in preventing obesity. 7,8 Childhood activity patterns may be particularly important if they persist into adulthood.…”

Physical Activity Correlates with Arterial Stiffness in Community-dwelling Individuals with Stroke

“…25 Conversely, increased physical activity, particularly exercise that is aerobic in nature, is effective in attenuating other atherosclerotic risk factors, such as hypertension, insulin resistance and glucose intolerance, dyslipidemia, and obesity. 26 Aerobic capacity was determined using a maximal exercise ramp protocol 27 on a leg cycle ergometer (Excalibur; Lode Medical Technology, Groningen, the Netherlands) and metabolic cart for measurement of breath-to-breath gas exchange (ParvoMedics, Sandy, UT). The American College of Sports Medicine guidelines for test termination were followed.…”