Exercise and Lymphocyte Activation following Chemotherapy for Breast Cancer

Hutnick, Natalie A.; Williams, Nancy I.; Kraemer, William J.; Orsega-Smith, Elizabeth; Dixon, Richard H.; Bleznak, Aaron D.; Mastro, Andrea M.

doi:10.1249/01.mss.0000175857.84936.1a

Cited by 117 publications

(139 citation statements)

References 24 publications

(24 reference statements)

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“…These findings are clinically significant as patients post chemotherapy and radiotherapy often gets secondary infections. So a moderate level of exercise regime can be effective in boosting immunity [40]. Similar results were observed by Waart et al, were they utilised exercises to minimise the decline in cardiorespiratory fitness, muscle strength and fatigue while undergoing chemotherapy.…”

Section: Physiotherapysupporting

confidence: 65%

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Yoga and Physical Therapy: Integrating as a way of Life in Cancer Patients

Seth¹,

Babbar²

2016

J Yoga Phys Ther

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Section: Physiotherapysupporting

confidence: 65%

“…Cancer patients (40) and nonc a n c e r patients (33) Scrambler therapy was given daily for 30 min for 5 days in a week for 2 weeks. A 2 weeks follow up was done at the end of treatment.…”

Section: N=73mentioning

confidence: 99%

Yoga and Physical Therapy: Integrating as a way of Life in Cancer Patients

Seth¹,

Babbar²

2016

J Yoga Phys Ther

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“…Despite its growth, the authors did not find statistically significant differences between trained and untrained groups (13). Hutnick et al, Demarzo et al, as well Mathur and Pedersen showed an increase in lymphocytes count and their activity in the peripheral blood together with increased physical activity (12,15,38). Lima et al compared the tumor mass and cell proliferation in trained and untrained rats.…”

Section: Discussionmentioning

confidence: 99%

“…Other studies showed that in animals physically active at puberty (rodent treadmill, tunnels and ladders), the risk of developing the disease is decreased, the possible tumor development is delayed and smaller-sized tumors are observed (5)(6)(7)(8)(9)(10)(11). Currently, a longer survival time is observed in individuals after cancer treatment who regularly exercise (12)(13)(14)(15)(16)(17) (23,24). Fairey et al found an increase in the number of NK cells in the blood of women who trained and had previously undergone breast cancer treatment (13).…”

mentioning

confidence: 99%

The Impact of Exercise Training on Breast Cancer

Siewierska

Malicka

Kobierzycki

et al. 2018

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Abstract. Background Breast cancer is still a major medical, social and economic problem due to the increasing prevalence and unsatisfactory treatment results. In 2013, nearly 235,000 new cases of breast cancer were reported in the United States, which accounted for 29% of all malignant neoplasms and was related to 14% risk of death. Based on current trends, over 23 million of new cases will be diagnosed by the year 2030 (1).Numerous scientific reports indicate the impact of physical activity on the development of breast cancer. However, the results are not conclusive (2-9). Westerlind et al. found that in girls aged 10-15 who were more active than their peers with a sedentary lifestyle the risk for developing breast cancer decreased by 30-50% (2). Studies on animal models also confirm this thesis. Malicka et al. demonstrated that moderate intensity training reduced the number of induced tumors in rats (4). Other studies showed that in animals physically active at puberty (rodent treadmill, tunnels and ladders), the risk of developing the disease is decreased, the possible tumor development is delayed and smaller-sized tumors are observed (5-11). Currently, a longer survival time is observed in individuals after cancer treatment who regularly exercise (12)(13)(14)(15)(16)(17). Holmes et al. demonstrated a reduction in the risk of death due to breast cancer in women who exercised (3-5 hours per week) after treatment compared to women with a sedentary lifestyle (18). Other research groups have confirmed these results (19)(20)(21)(22). Walsh et al. and Daroux-Cole et al. suggested that exercise stimulated the immune system in cancer patients (23,24). Fairey et al. found an increase in the number of NK cells in the blood of women who trained and had previously undergone breast cancer treatment (13). It should also be noted that Demarzo and Garcia demonstrated an increase of breast tumor incidence in rats after intense exercise compared to untrained rats (25). Experiments on rats are a recognized model of experimental breast cancer research. The mammary gland model of rodents shows a significant similarity to the human mammary gland. In rodents, terminal end buds are the basic structures forming the mammary ridge while in humans it is the duct lobular unit which forms the 249 This article is freely accessible online.

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“…Evidence includes a substantial number of peer-reviewed articles on the benefits of exercise alone and greatly supports the use of rehabilitation interventions in various cancer populations 12 . Systematic analysis of that research shows a positive effect at all stages of disease for reducing fatigue [13][14][15] ; improving tolerance to treatment [16][17][18] ; significantly improving time to recovery 19 and sleep 20 ; and enhancing immune function 21 , cardiovascular function 15 and health-related quality of life 18,22 . Reports of positive outcomes are mounting 23 , and it has become imperative to develop models of care that systematically include rehabilitation and exercise prescription.…”

Section: Introductionmentioning

confidence: 99%