Exercise and longevity

Grémeaux, Vincent; Gayda, Mathieu; Lepers, Romuald; Sosner, P.; Juneau, Martin; Nigam, Anil

doi:10.1016/j.maturitas.2012.09.012

Cited by 173 publications

(127 citation statements)

References 63 publications

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“…By contrast, a high level of education may be linked to increased knowledge of health or greater physical activity. Physical activity may help to maintain bone health [18]. Our result also illustrated that people employed in fields involving extensive manual labor had a lower risk of bone cancer mortality.…”

Section: Discussionsupporting

confidence: 55%

Bone Cancer Mortality in Inner Mongolia from 2008 to 2012

Guo¹,

Hao²,

Du³

et al. 2015

OJEpi

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Objective: The aim of our study was to assess bone cancer mortality and the related social factors in Inner Mongolia in China. Methods: We obtained data from the Centers for Disease Control in Inner Mongolia from five monitoring points of the Death Registry System in Inner Mongolia from 2008 to 2012. We calculated the crude mortality rate for bone cancer. The χ 2 test was used to examine differences in bone cancer mortality rates between sexes and years. Unconditional logistic regressions were applied to analyze the effect of socio-demographic characteristics by sex. Results: Between 2008 and 2012, the crude mortality rate of bone cancer was 1.12/100000 (95% confidence interval = 1.02 -1.21). The bone cancer mortality was 2.24 in men and 1.25 in women, resulting in a male-female ratio of 1.8. No between-year difference in the mortality rate was observed between 2008 and 2012 (men: χ 2 = 4.65, P = 0.325; women: χ 2 = 2.21, P = 0.698). In general, mortality increased with increasing age. People with a lower education level exhibited an increased risk of bone cancer among both men and women. Jobs involving extensive manual labor decreased the likelihood of bone cancer mortality, and the odds ratio was higher for men than women (0.6 vs. 0.45). Unmarried people had a higher risk for bone cancer than married people. Conclusion: The mortality rate of bone cancer was not significantly different between men and women from 2008 to 2012. The risk of bone cancer increased with age among both sexes. Unmarried people and those with a low education status had an elevated risk of bone cancer, whereas employment in a field involving extensive manual labor appeared to be a protective factor against bone cancer.

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Section: Discussionsupporting

confidence: 55%

Bone Cancer Mortality in Inner Mongolia from 2008 to 2012

Guo¹,

Hao²,

Du³

et al. 2015

OJEpi

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“…Exercise is widely accepted as one of the most efficient treatments against the effects of systemic and muscle‐specific aging (Garatachea et al., 2015; Gremeaux et al., 2012). We show here that even when performed only at old age, exercise is sufficient to prevent or even improve many age‐related deteriorations.…”

Section: Discussionmentioning

confidence: 99%

PGC‐1α affects aging‐related changes in muscle and motor function by modulating specific exercise‐mediated changes in old mice

et al. 2017

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SummaryThe age‐related impairment in muscle function results in a drastic decline in motor coordination and mobility in elderly individuals. Regular physical activity is the only efficient intervention to prevent and treat this age‐associated degeneration. However, the mechanisms that underlie the therapeutic effect of exercise in this context remain unclear. We assessed whether endurance exercise training in old age is sufficient to affect muscle and motor function. Moreover, as muscle peroxisome proliferator‐activated receptor γ coactivator 1α (PGC‐1α) is a key regulatory hub in endurance exercise adaptation with decreased expression in old muscle, we studied the involvement of PGC‐1α in the therapeutic effect of exercise in aging. Intriguingly, PGC‐1α muscle‐specific knockout and overexpression, respectively, precipitated and alleviated specific aspects of aging‐related deterioration of muscle function in old mice, while other muscle dysfunctions remained unchanged upon PGC‐1α modulation. Surprisingly, we discovered that muscle PGC‐1α was not only involved in improving muscle endurance and mitochondrial remodeling, but also phenocopied endurance exercise training in advanced age by contributing to maintaining balance and motor coordination in old animals. Our data therefore suggest that the benefits of exercise, even when performed at old age, extend beyond skeletal muscle and are at least in part mediated by PGC‐1α.

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“…Nevertheless, even if recreational masters athletes had relatively short training histories and little experience in triathlon, these successful athletes probably have lifelong histories of physical activity. [110,111,112,113] …”

Section: Improvements In Triathlon Performance Of Elderly Triathletesmentioning

confidence: 99%

Trends in Triathlon Performance: Effects of Sex and Age

2013

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The influences of sex and age upon endurance performance have previously been documented for both running and swimming. A number of recent studies have investigated how sex and age influence triathlon performance, a sport that combines three disciplines (swimming, cycling and running), with competitions commonly lasting between two (Short distance : 1.5 km swim, 40 km cycle and 10 km run) and eight hours (Ironman distance: 3.8 km swim, 180 km cycle and 42 km run) for elite triathletes. Age and sex influences upon performance have also been investigated for ultra-triathlons with distances corresponding to several Ironman distances and lasting several days, and for off-road triathlons combining swimming, mountain biking and trail running. Triathlon represents an intriguing alternative model for analyzing the effects of age and sex upon endurance and ultra-endurance (> 6 hours) performance because sex differences and age-related declines in performance can be analyzed in the same persons across the three separate disciplines. The relative participation of both females and masters athletes (age > 40 years old) in triathlon has increased consistently over the past 25 years. Sex differences in triathlon performance are also known to differ between the modes of locomotion adopted (swimming, cycling or running) for both elite and non-elite triathletes.Generally, time differences between sexes in swimming have been shown to be smaller on average than during cycling and running. Both physiological and morphological factors contribute to explaining these findings. Performance density (i.e. the time difference between the winner and 10 th placed competitor) has progressively improved (time differences have decreased) for international races over the past two decades for both males and females, with performance density now very similar for both sexes. For age-group triathletes, sex differences in total triathlon performance time increases with age. The possible difference in age-related changes in the physiological determinants of endurance and ultra-endurance performances between males and females needs further investigation however. Non-

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Exercise and longevity

Cited by 173 publications

References 63 publications

Bone Cancer Mortality in Inner Mongolia from 2008 to 2012

Bone Cancer Mortality in Inner Mongolia from 2008 to 2012

PGC‐1α affects aging‐related changes in muscle and motor function by modulating specific exercise‐mediated changes in old mice

Trends in Triathlon Performance: Effects of Sex and Age

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