Exercise and inflammation in coronary artery disease: A systematic review and meta-analysis of randomised trials

Thompson, Gareth; Davison, Gareth W.; Crawford, Jacqui; Hughes, Ciara

doi:10.1080/02640414.2020.1735684

Cited by 17 publications

(13 citation statements)

References 76 publications

(201 reference statements)

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“…112 Furthermore, a systematic review and meta-analysis of the anti-inflammatory effects of exercise in patients with coronary artery disease found that post exercise C-reactive protein and von Willebrand factor were significantly lower in exercise groups, but its impact on inflammatory cytokines was equivocal. 113…”

Section: Exercise Effects On Metabolic Healthmentioning

confidence: 99%

Exercise, Physical Activity, and Cardiometabolic Health

Belanger

Rao

Robbins

2022

Cardiology in Review

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Physical activity and its sustained and purposeful performance—exercise—promote a broad and diverse set of metabolic and cardiovascular health benefits. Regular exercise is the most effective way to improve cardiorespiratory fitness, a measure of one’s global cardiovascular, pulmonary and metabolic health, and one of the strongest predictors of future health risk. Here, we describe how exercise affects individual organ systems related to cardiometabolic health, including the promotion of insulin and glucose homeostasis through improved efficiency in skeletal muscle glucose utilization and enhanced insulin sensitivity; beneficial changes in body composition and adiposity; and improved cardiac mechanics and vascular health. We subsequently identify knowledge gaps that remain in exercise science, including heterogeneity in exercise responsiveness. While the application of molecular profiling technologies in exercise science has begun to illuminate the biochemical pathways that govern exercise-induced health promotion, much of this work has focused on individual organ systems and applied single platforms. New insights into exercise-induced secreted small molecules and proteins that impart their effects in distant organs (“exerkines”) highlight the need for an integrated approach towards the study of exercise and its global effects; efforts that are ongoing.

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Section: Exercise Effects On Metabolic Healthmentioning

confidence: 99%

Exercise, Physical Activity, and Cardiometabolic Health

Belanger

Rao

Robbins

2022

Cardiology in Review

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“…On the other hand, two meta-analyses [ 13 , 46 ] investigated the effect of exercise on the inflammatory activity of these patients. They observed that exercise could induce an anti-inflammatory effect.…”

Section: Effects Of Exercise In Cad Patientsmentioning

confidence: 99%

“…They observed that exercise could induce an anti-inflammatory effect. Specifically, Thompson et al [ 13 ] showed that there was evidence of how exercise produced significant beneficial effects on the C-reactive protein, fibrinogen and von Willebrand factor, but no significant differences were detected in interleukin-6 (IL6), interleukin-8 (IL8), interleukin-10 (IL10), tumor necrosis factor-alpha (TNFα), vascular cell adhesion molecule (VCAM), intercellular adhesion molecule-1 (ICAM1), E-Selectin, P-Selectin and normal T-cell expressed and secreted (RANTES). This reduction in inflammatory activity may be due to the fact that these patients have elevated basal levels, or to an improvement in the main risk factors for CAD that promote inflammation, such as obesity, diabetes, hypertension and dyslipidaemia [ 13 ].…”

Section: Effects Of Exercise In Cad Patientsmentioning

confidence: 99%

“…Likewise, patients with CAD will present low-grade chronic systemic inflammation that will affect the vascular system [ 13 ]. Vascular inflammation involves the activation of platelets and leukocytes, which is an early characteristic of atherosclerotic disease since platelets will produce inflammatory and mitogenic molecules (interleukins, chemokines…) that facilitate the adhesion of monocytes and leukocytes to the endothelium.…”

Section: Introductionmentioning

confidence: 99%

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Exercise Training and Interventions for Coronary Artery Disease

Fernández-Rubio

Becerro‐de‐Bengoa‐Vallejo

Rodríguez‐Sanz

et al. 2022

JCDD

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Coronary artery disease (CAD) may be considered a main cause of mortality and the prevalence of CAD is increasing nowadays, leading to high health costs in many countries. Despite the fact of the regression of the atherosclerotic plaque, the decrease in blood viscosity and the growth of collateral vessels have been proposed as improvements that CAD patients may obtain under exercise performance. Thus, the present narrative review aimed to carry out a brief specific analysis of the results achieved when performing endurance, strength or inspiratory muscle training. Exercise attenuates certain pathophysiological processes of this disease, such as endothelial dysfunction or the vulnerability of atherosclerotic plaques, and produces improvements in functional capacity and muscle strength, among others. Within the different exercise modalities, the most important parameter to be considered seems to be the total caloric expenditure, and not so much the modality itself. As such, in cardiac rehabilitation, when prescribing exercise, we should possibly focus on the modality that obtains more adherence in patients. To conclude, it must be highlighted that total caloric expenditure is not being taken into account when comparing interventions and this relevant information should be considered in future studies.

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“…In addition, its impact on other sites such as the pulmonary and musculoskeletal systems should also be kept in mind, particularly when analysing data related to overall functional capacity as well as its impact in the face of the complex multimorbidity patient[ 20 , 31 - 33 ]. Moreover, and given recent reports illustrating the putative role of inflammation in IHD, the potential modulation of inflammatory pathways by physical activity has also been postulated as being one of the mechanisms underlying the benefits of exercise-based CR[ 25 , 34 ]. Of note, however, that while some mechanistic as well as clinical data have supported this hypothesis, further research is still needed to fully ascertain the potential relative contribution of inflammatory modulation and metabolic substrate utilization to the overall improvements in individuals undergoing CR[ 25 , 34 - 36 ].…”

Section: Cr In Ischaemic Heart Diseasementioning

confidence: 99%

Current role and future perspectives of cardiac rehabilitation in coronary heart disease

Vilela¹,

Ladeiras-Lopes²,

João³

et al. 2021

WJC

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Ischaemic heart disease (IHD) is a major cause of morbidity and mortality worldwide. While there have been major advances in this field, these patients are still a higher risk subgroup. As such, strategies to mitigate risk and tailor secondary prevention measures are of the utmost relevance. Cardiac rehabilitation (CR), encompassing several domains including exercise training, cardiovascular risk factor optimization, nutritional and psychological assessments, as well as other ancillary interventions has shown to be one of the pillars in the contemporary management of patients with IHD. Indeed, CR is associated with several benefits in this population, ranging from functional capacity to improvements in outcomes. Whilst this, there are still several issues concerning the optimal application of CR which are still not fully ascertained, such as lack of referral and completion, as well as questions related to programme design (particularly among patients with multiple comorbidities). In this review, we aim at presenting a pragmatic overview on the current role of CR in the management of individuals with IHD, while also discussing some of the caveats in the current data, as well as future concepts which could help improve the uptake and personalization of this pivotal time-tested intervention.

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Exercise and inflammation in coronary artery disease: A systematic review and meta-analysis of randomised trials

Cited by 17 publications

References 76 publications

Exercise, Physical Activity, and Cardiometabolic Health

Exercise, Physical Activity, and Cardiometabolic Health

Exercise Training and Interventions for Coronary Artery Disease

Current role and future perspectives of cardiac rehabilitation in coronary heart disease

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