Exercise and immobilization in aging animals: The involvement of oxidative stress and NF-κB activation

Bar-Shai, Marina; Carmeli, Eli; Ljubuncic, Predrag; Reznick, Abraham Z.

doi:10.1016/j.freeradbiomed.2007.03.019

Cited by 112 publications

(85 citation statements)

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“…Low physical activity is one of the hallmarks of frailty (18), and has been consistently reported to significantly increase OS in both animal models and humans (13,32). Therefore, a vicious circle may occur between OS and frailty.…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress and frailty: A systematic review and synthesis of the best evidence

et al. 2017

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Highlights There is a lack of clarity around the relationship between oxidative stress and frailty.  Our review provides some cross sectional evidence of increased oxidative stress among frail older people.  There is some preliminary evidence of lower anti-oxidant parameters (vitamin C, E, α-tocopherol, biological anti-oxidant potential, total thiol levels) in frailty. ABSTRACT (250/250)Objective: Oxidative stress (OS) is associated with accelerated aging. Previous studies have suggested a possible relationship between OS and frailty but this association remains unclear.We conducted a systematic review to investigate potential interactions between OS and frailty.Methods: A systematic literature search of original reports providing data on 'OS and antioxidant' parameters and frailty was carried out across major electronic databases from inception until May 2016. Cross-sectional/case control and longitudinal studies reporting data on the association between frailty and anti-oxidants-OS biomarkers were considered for inclusion. Results were summarized with a best-evidence based synthesis.Results: From 1,856 hits, 8 studies (cross-sectional/case control) were included (N=6,349; mean age of 75±12 years; 56.4% females). Overall, there were 588 (=9.3%) frail, 3,036 prefrail (=47.8%), 40 (=0.6%) pre-frail/robust, and 2,685 (=42.3%) robust subjects. Six crosssectional/case control studies demonstrated that frailty was associated with an increase in peripheral OS biomarkers including lipoprotein phospholipase A2 (studies=1), isoprostanes (studies=2), Malonaldehyde (studies=2), 8-hydroxy-20-deoxyguanosine (studies=2), derivate of reactive oxygen metabolites (studies=2), oxidized Glutathione/ Glutathione (studies=1), 4-hydroxy-2,3-nonenal (studies=1), and protein carbonylation levels (study=1). In addition, preliminary evidence points to lower anti-oxidant parameters (vitamin C, E, α-tocopherol, biological anti-oxidant potential, total thiol levels) in frailty. Conclusion:Frailty and pre-frailty appear to be associated with higher OS and possibly lower anti-oxidant parameters. However, due to the cross sectional design, it is not possible to disentangle the directionality of the relationships observed. Thus, future high quality and in particular longitudinal research is required to confirm/refute these relationships and to further elucidate pathophysiological mechanisms.

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Section: Discussionmentioning

confidence: 99%

Oxidative stress and frailty: A systematic review and synthesis of the best evidence

et al. 2017

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“…Because the physiological effects of exercise are dose-dependent (Urso et al 2009), the duration of the training protocol seems to alter the metabolic, immune, and endocrine consequences of exercise. Indeed, Bar-Shai and colleagues (Bar-Shai et al 2008) proposed that if physical training is initiated prior to a critical physiological threshold in younger rodents, it may prove beneficial for the muscles and bones of older animals, but not in short-term trained elderly animals. Moreover, a recent population-based cohort study of 2,205 men with follow-up over 35 years concluded that there is a graded reduction in the total mortality risk at old ages with increasing physical activity levels during middle age (Byberg et al 2009).…”

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confidence: 99%

Long-term training induces a healthy inflammatory and endocrine emergent biomarker profile in elderly men

Gonzalo-Calvo

Fernández‐García

Luxán-Delgado

et al. 2011

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The objective of the present study was to investigate the changes in a large panel of emergent geriatric biomarkers in long-term trained elderly men to analyze the effects of long-term exercise on an aged population. We collected blood samples from two groups of male volunteers older than 65 years who maintain a measure of functional independence: one group of sedentary subjects without a history of regular physical activity and the other of subjects who have sustained training, starting during adulthood (mean training time=49±8 years). We studied morbidity, polypharmacy, cellular and serological inflammatory parameters, and endocrine mediators. After adjusting for confounding factors, we observed reduced medication intake per subject and lower number of diseases per subject with statistical differences nearly significant in the long-term exercise group. We showed that long-term training was associated with lower levels of white blood cell counts, neutrophil counts, interleukin-6, interleukin-10, interleukin-1 receptor antagonist, and soluble TNF receptor-I. Furthermore, we noted an increase in the concentrations of insulin-like growth factor-1 and dehydroepiandrosterone in the long-term training group. We concluded that long-term exercise training from adulthood to old age is clearly associated with a healthy profile of emergent geriatric biomarkers. Long-term training could improve the inflammatoryendocrine imbalance associated with disease, frailty, functional decline, and mortality in elderly men. Our results point to the benefits of prolonged exercise from adulthood to old age.

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“…Previous studies had shown that the expression of HMGB1, TNF-a, IL-6 was regulated by NF-κB. However NF-κB as a oxidation-reduction related sensitive transcription factor was under the regulation of ROS (Pahl 1999;Bar-Shai et al 2008). It was known that UTI may through suppress the expression of HMGB1 (Koga et al 2010), TNF-a (Cao et al 2010), IL-6 (Park et al 2010a) to act as anti-inflammatory.…”

Section: Decrease the Production Of Omentioning

confidence: 99%

Ulinastatin and Septic Cardiac Dysfunction

Lin¹,

Lin²

2012

The Transmission Electron Microscope

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Exercise and immobilization in aging animals: The involvement of oxidative stress and NF-κB activation

Cited by 112 publications

References 100 publications

Oxidative stress and frailty: A systematic review and synthesis of the best evidence

Oxidative stress and frailty: A systematic review and synthesis of the best evidence

Long-term training induces a healthy inflammatory and endocrine emergent biomarker profile in elderly men

Ulinastatin and Septic Cardiac Dysfunction

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