Exercise and food supplement of vitamin C ameliorate hypertension through improvement of gut microflora in the spontaneously hypertensive rats

Liu, Ying; Zafar, Salman; Ibrahim, Rawya Mohamed Salih; Chi, Hongli; Xiao, Tong; Xia, Wenjie; Li, Hong-Bao; Kang, Yu-Ming

doi:10.1016/j.lfs.2021.119097

Cited by 32 publications

(21 citation statements)

References 58 publications

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“…Owing to the microbiota s plasticity, lifestyle interventions (mainly in diet, exercise, and stress) are being increasingly recognized for their impact on physical and mental health, through gut-microbiota-mediated actions [136]. Exercise has been demonstrated to especially have an impact on Firmicutes and Actinobacteria [137,138], which include the Lactobacillus and Bifidobacterium genera, respectively, and to induce changes in the diversity and microbial production of SCFAs, specifically butyrate [139], which improves anxiety scores [140].…”

mentioning

confidence: 99%

Gut Microbiota and Neuroplasticity

Murciano-Brea

Garcia-Montes

Geuna

et al. 2021

Cells

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The accumulating evidence linking bacteria in the gut and neurons in the brain (the microbiota–gut–brain axis) has led to a paradigm shift in the neurosciences. Understanding the neurobiological mechanisms supporting the relevance of actions mediated by the gut microbiota for brain physiology and neuronal functioning is a key research area. In this review, we discuss the literature showing how the microbiota is emerging as a key regulator of the brain’s function and behavior, as increasing amounts of evidence on the importance of the bidirectional communication between the intestinal bacteria and the brain have accumulated. Based on recent discoveries, we suggest that the interaction between diet and the gut microbiota, which might ultimately affect the brain, represents an unprecedented stimulus for conducting new research that links food and mood. We also review the limited work in the clinical arena to date, and we propose novel approaches for deciphering the gut microbiota–brain axis and, eventually, for manipulating this relationship to boost mental wellness.

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confidence: 99%

Gut Microbiota and Neuroplasticity

Murciano-Brea

Garcia-Montes

Geuna

et al. 2021

Cells

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“…In addition, Treponema , Romboutsia , and Turicibacter were significantly increased at the genus level (Figure 1J). Notably, these altered genera are involved in SCFAs production (Kreznar et al, 2017; Li et al, 2019b; Li et al, 2021; Li et al, 2019c; Bian et al, 2020). These results verify that MSTN deficiency can alter the intestinal structure while promoting the growth of microbes related to SCFAs production.…”

Section: Resultsmentioning

confidence: 99%

“…The intestinal microflora composition of MSTN −/− pigs was analyzed, and we found that Romboutsia , Treponema, and Turicibacter were significantly enriched. Several studies have suggested that these microbes are involved in SCFAs production (Li et al, 2019b; Li et al, 2021; Li et al, 2019c; Bian et al, 2020). SCFAs are absorbed from the intestinal tract and play a metabolic regulatory role in different organs, which are recognized as a potential regulator of skeletal muscle metabolism and function (Frampton et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Myostatin gene deletion alters gut microbiota stimulating fast-twitch glycolytic muscle growth

Luo

Han

Yin

et al. 2022

Preprint

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The host genome may influence the composition of the intestinal microbiota, and intestinal microbiota performs an important role in muscle growth and development. Here, we showed that Myostatin (MSTN), a key factor for muscle growth, deletion alters muscularis, plica, and intestinal barrier in pigs. Mice transplanted with MSTN−/− pig intestinal flora showed increase in the cross-sectional area of myofibers and fast-twitch glycolytic muscle mass. The microbes responsible for the production of short chain fatty acids (SCFAs) were enriched in both MSTN−/− pigs and recipient mice, and SCFAs levels were elevated in the colon contents. We demonstrated that valeric acid can stimulate type IIb myofiber growth by activation of the Akt/mTOR pathway via GPR43 and improve muscle atrophy induced by dexamethasone. This is the first study to identify the MSTN gene-gut microbiota-SCFA axis and its regulatory role in fast-twitch glycolytic muscle growth.

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“…Exercise, associated with a supplementation of vitamin C, proved to be beneficial in reducing blood pressure value, along with down-regulating pro-inflammatory cytokines (PIC), in the gut mucosa, and reactive oxygen species (ROS), in the hypothalamus paraventricular nucleus (PVN), while up-regulating the anti-inflammatory cytokines (AIC) in the intestinal mucosa. Also, the intestinal microbiota showed significant improvement, through the up-regulation of deficient micro-organisms, such as Turicibacter and Romboutsia, involved in the production of short-chain fatty acids [ 124 ].…”

Section: The Benefits Of Physical Exercise: Good But Not Perfectmentioning

confidence: 99%

Beyond the Finish Line: The Impact and Dynamics of Biomarkers in Physical Exercise—A Narrative Review

Costache

Miftode

et al. 2021

JCM

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The research of biomarkers continues to emerge as a developing academic field which is attracting substantial interest. The study of biomarkers proves to be useful in developing and implementing new screening methods for a wide variety of diseases including in the sports area, whether for leisure activities or professional sports. Novel research has brought into question the immune system and the limitations it may impose on sports practicing. As the well-being of athletes is a priority, the state of their immune function offers valuable information regarding their health status and their ability to continue training. The assessment of various biomarkers may contribute to a more accurate risk stratification and subsequent prevention of some invalidating or even fatal pathologies such as the sudden cardiac death. Therefore, we have reviewed several studies that included sports-related pathology or specific morphofunctional alterations for which some immune biomarkers may represent an expression of the underlying mechanism. These include the defensins, immunoglobulin A (IgA), interleukin-6 (IL-6), the tumoral necrosis factor α (TNF-α), and the white blood cells (WBC) count. Similarly, also of significant interest are various endocrine biomarkers, such as cortisol and testosterone, as well as anabolic or catabolic markers, respectively. Literature data highlight that these values are greatly influenced not only by the duration, but also by the intensity of the physical exercise; moderate training sessions actually enhance the immune function of the body, while a significant increase in both duration and intensity of sports activity acts as a deleterious factor. Therefore, in this paper we aim to highlight the importance of biomarkers’ evaluation in connection with sports activities and a subsequent more adequate approach towards personalized training regimens.

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Exercise and food supplement of vitamin C ameliorate hypertension through improvement of gut microflora in the spontaneously hypertensive rats

Cited by 32 publications

References 58 publications

Gut Microbiota and Neuroplasticity

Gut Microbiota and Neuroplasticity

Myostatin gene deletion alters gut microbiota stimulating fast-twitch glycolytic muscle growth

Beyond the Finish Line: The Impact and Dynamics of Biomarkers in Physical Exercise—A Narrative Review

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