Exercise adaptations and TGF-β1 levels in recreational cyclists

Widiastuti, Ida Ayu Eka; Arsyad, Aryadi; Idris, Irfan; Patellongi, Ilhamjaya; Kadriyan, Hamsu; Buanayuda, Gede Wira; Sari, Dian Puspita; Rosyidi, Rohadi Muhammad

doi:10.1016/j.amsu.2021.102872

Cited by 6 publications

(6 citation statements)

References 25 publications

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“…They observed that the level of TGF-β1 was lower in the recreational cyclist than in the sedentary control group. Several other studies have confirmed that participating in moderate regular exercise would reduce the level of circulating TGF-β in both human and rodents [ 49 - 51 ].…”

Section: Resultsmentioning

confidence: 93%

“…They observed that 8 min/d (moderate) swimming decreased TGF-β1 levels both in serum and liver cancer tissues. In humans, a study compared the level of TGF-β1 in the regular cyclist (2–3 times a week, average 30–60 min each) with sedentary control [ 49 ]. They observed that the level of TGF-β1 was lower in the recreational cyclist than in the sedentary control group.…”

Section: Resultsmentioning

confidence: 99%

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Potential involvement of neutrophils on exercise effects in breast cancer malignancy

Ko,

Woo,

Chae

et al. 2023

Phys Act Nutr

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[Purpose] This review aimed to comprehensively explore and elucidate multifaceted neutrophils in breast cancer, particularly in the context of physical activity. Neutrophils play a critical role in the tumor microenvironment and systemic immune response, despite their short half-life and terminal differentiation. Through a thorough review of research related to changes in immunity in breast cancer during exercise, this review aims to provide comprehensive insights into immunological changes, especially focusing on neutrophils. Recognizing that much of the existing research has predominantly focused on T cells and nature killer (NK) cells, our review seeks to shift the spotlight toward understanding how exercise affects neutrophils, a less-explored but critical immune response component in breast cancer.[Methods] This study involved an extensive review of the literature (from 2000 to 2023) using the PubMed, Science Direct, and Google Scholar databases. The keywords chosen for the searches were “immune cells and exercise,” “exercise and breast cancer,” “tumor microenvironment and neutrophils,” and “neutrophils and exercise and breast cancers.”[Results] Neutrophils in the tumor microenvironment can exhibit distinct phenotypes and functions. These differences have yielded conflicting results regarding tumor progression. Exercise plays a positive role in breast cancer and alters the immune system. Physical activity can quantitatively and functionally regulate neutrophils under various conditions such as metabolic disruption or senescence.[Conclusion] This short communication outlines exercise-induced neutrophil diversification and its role in breast cancer progression, both within and systemically within the tumor microenvironment. Exercise may provide benefits through the potential neutrophil involvement in breast cancer.

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Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Potential involvement of neutrophils on exercise effects in breast cancer malignancy

Ko,

Woo,

Chae

et al. 2023

Phys Act Nutr

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“…The context in which this influence is explored and the timing after the PE could explain some of this variability. Regarding TGF-β, a key cytokine for tissue remodeling, given the context PE can either increase [ 57 , 58 , 59 ] or decrease [ 60 , 61 , 62 ] its production.…”

Section: Discussionmentioning

confidence: 99%

Low-Intensity Physical Exercise Decreases Inflammation and Joint Damage in the Preclinical Phase of a Rheumatoid Arthritis Murine Model

et al. 2023

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Lifestyle modifications in preclinical Rheumatoid Arthritis (RA) could delay the ongoing pathogenic immune processes and potentially prevent its onset. Physical exercise (PE) benefits RA patients; however, its impact in reducing the risk of developing RA has scarcely been studied. The objective was to describe the effects of low-intensity PE applied at the disease’s preclinical phase on the joints of DBA/1 mice with collagen-induced arthritis (CIA). Twelve mice with CIA were randomly distributed into two groups: the CIA-Ex group, which undertook treadmill PE, and the CIA-NoEx, which was not exercised. The effects of PE were evaluated through clinical, histological, transcriptomics, and immunodetection analyses in the mice’s hind paws. The CIA-Ex group showed lower joint inflammation and damage and a decreased expression of RA-related genes (Tnf Il2, Il10, Il12a, IL23a, and Tgfb1) and signaling pathways (Cytokines, Chemokines, JAK-STAT, MAPK, NF-kappa B, TNF, and TGF-beta). TNF-α expression was decreased by PE in the inflamed joints. Low-intensity PE in pre-arthritic CIA reduced the severity through joint down-expression of proinflammatory genes and proteins. Knowledge on the underlying mechanisms of PE in preclinical arthritis and its impact on reducing the risk of developing RA is still needed.

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“…Because ROS are produced more frequently when TGF-beta-1 (TGF-β1) is present in low concentrations, this would result in increased fitness. Consistent exercise starts a process of adaptation that makes antioxidant enzymes work harder to prevent TGF-β1 activation [ 82 ]. TGF-β1 and bone morphogenic protein (BMP) signaling are also crucial for chondrogenic and osteogenic differentiation.…”

Section: Interconnected Bone and Muscle Molecular Pathwaysmentioning

confidence: 99%

Crosstalk between Bone and Muscles during Physical Activity

Dalle Carbonare,

Minoia,

Zouari

et al. 2023

Cells

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Bone–muscle crosstalk is enabled thanks to the integration of different molecular signals, and it is essential for maintaining the homeostasis of skeletal and muscle tissue. Both the skeletal system and the muscular system perform endocrine activity by producing osteokines and myokines, respectively. These cytokines play a pivotal role in facilitating bone–muscle crosstalk. Moreover, recent studies have highlighted the role of non-coding RNAs in promoting crosstalk between bone and muscle in physiological or pathological conditions. Therefore, positive stimuli or pathologies that target one of the two systems can affect the other system as well, emphasizing the reciprocal influence of bone and muscle. Lifestyle and in particular physical activity influence both the bone and the muscular apparatus by acting on the single system but also by enhancing its crosstalk. Several studies have in fact demonstrated the modulation of circulating molecular factors during physical activity. These molecules are often produced by bone or muscle and are capable of activating signaling pathways involved in bone–muscle crosstalk but also of modulating the response of other cell types. Therefore, in this review we will discuss the effects of physical activity on bone and muscle cells, with particular reference to the biomolecular mechanisms that regulate their cellular interactions.

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Exercise adaptations and TGF-β1 levels in recreational cyclists

Cited by 6 publications

References 25 publications

Potential involvement of neutrophils on exercise effects in breast cancer malignancy

Potential involvement of neutrophils on exercise effects in breast cancer malignancy

Low-Intensity Physical Exercise Decreases Inflammation and Joint Damage in the Preclinical Phase of a Rheumatoid Arthritis Murine Model

Crosstalk between Bone and Muscles during Physical Activity

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