Exercise-acclimated microbiota improves skeletal muscle metabolism via circulating bile acid deconjugation

Aoi, Wataru; Inoüe, Ryo; Mizushima, Katsura; Honda, Akira; Björnholm, Marie; Takagi, Tomohisa; Naito, Yuji

doi:10.1016/j.isci.2023.106251

Cited by 11 publications

(7 citation statements)

References 69 publications

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“…It is important to note that besides acetate, the gut microbiota also produces various other metabolites, including branched-chain amino acids, biogenic amines, bile acids, trimethylamine N-oxide, tryptophan, and indole derivatives [36]. In recent years, bile acids have been found to affect glucose metabolism, insulin sensitivity, metabolic dysfunction, mass, and atrophy of skeletal muscle [32,[37][38][39]. Meanwhile, regarding branched-chain amino acids, it has been reported that skeletal muscle growth and development are closely related to branchedchain amino acid metabolism [40,41].…”

Section: Discussionmentioning

confidence: 99%

Acetate Alleviates Gut Microbiota Depletion-Induced Retardation of Skeletal Muscle Growth and Development in Young Mice

Yang,

Zhang,

Liu

et al. 2024

IJMS

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The normal growth and development of skeletal muscle is essential for the health of the body. The regulation of skeletal muscle by intestinal microorganisms and their metabolites has been continuously demonstrated. Acetate is the predominant short-chain fatty acids synthesized by gut microbiota through the fermentation of dietary fiber; however, the underlying molecular mechanisms governing the interaction between acetate and skeletal muscle during the rapid growth stage remains to be further elucidated. Herein, specific pathogen-free (SPF) mice, germ-free (GF) mice, and germ-free mice supplemented with sodium acetate (GS) were used to evaluate the effects of acetate on the skeletal muscle growth and development of young mice with gut microbiota deficiency. We found that the concentration of serum acetate, body mass gain, succinate dehydrogenase activity, and expression of the myogenesis maker gene of skeletal muscle in the GS group were higher than those in the GF group, following sodium acetate supplementation. Furthermore, the transcriptome analysis revealed that acetate activated the biological processes that regulate skeletal muscle growth and development in the GF group, which are otherwise inhibited due to a gut microbiota deficiency. The in vitro experiment showed that acetate up-regulated Gm16062 to promote skeletal muscle cell differentiation. Overall, our findings proved that acetate promotes skeletal muscle growth and development in young mice via increasing Gm16062 expression.

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Section: Discussionmentioning

confidence: 99%

Acetate Alleviates Gut Microbiota Depletion-Induced Retardation of Skeletal Muscle Growth and Development in Young Mice

Yang,

Zhang,

Liu

et al. 2024

IJMS

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“…In contrast, calorie restriction significantly altered microbiota and decreased the levels of non-12α-hydroxylated BAs ( Li et al, 2022 ). Exercise could also regulate intestinal microbiota and induce metabolic improvements by modifying circulating BAs ( Aoi et al, 2023 ). The molecular mechanism underlying metabolic improvement by exercise may involve FXR-FGF15 signaling ( Qiu et al, 2021 ).…”

Section: Targeting Ba Metabolism For Nafld Therapymentioning

confidence: 99%

Regulating bile acids signaling for NAFLD: molecular insights and novel therapeutic interventions

Wei,

Tu,

Huang

2024

Front. Microbiol.

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Nonalcoholic fatty liver disease (NAFLD) emerges as the most predominant cause of liver disease, tightly linked to metabolic dysfunction. Bile acids (BAs), initially synthesized from cholesterol in the liver, undergo further metabolism by gut bacteria. Increasingly acknowledged as critical modulators of metabolic processes, BAs have been implicated as important signaling molecules. In this review, we will focus on the mechanism of BAs signaling involved in glucose homeostasis, lipid metabolism, energy expenditure, and immune regulation and summarize their roles in the pathogenesis of NAFLD. Furthermore, gut microbiota dysbiosis plays a key role in the development of NAFLD, and the interactions between BAs and intestinal microbiota is elucidated. In addition, we also discuss potential therapeutic strategies for NAFLD, including drugs targeting BA receptors, modulation of intestinal microbiota, and metabolic surgery.

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“…Recently, exercise has been considered as a potentially effective intervention for gut frailty. A study using a mouse exercise model demonstrated that fecal microbiota changed with exercise, resulting in increased levels of bile acids as revealed by metabolomic analysis [32]. Absorbed bile acids are involved in the maintenance of skeletal muscle through the TGR-5 As the underlying pathology of gut frailty remains unclear, definitive treatments and prevention methods are currently in the research phase and several potential approaches have been suggested.…”

Section: Gut Frailtymentioning

confidence: 99%

Gut Frailty: Its Concept and Pathogenesis

Naito

2023

Digestion

Self Cite

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Background: There is still a considerable gap between average life expectancy and healthy life expectancy in Japan. Recent research has revealed that gut frailty may be a worsening factor for various diseases, a cause of chronic inflammation, and a precursor to frailty. Summary: Among self-reported symptoms, constipation is particularly significant as one of the key symptoms of gut frailty. Studies have demonstrated that individuals with constipation have significantly lower survival rates and are also at a higher risk of developing various diseases such as chronic kidney disease, cardiovascular diseases, and neurodegenerative disorders like Parkinson’s disease. Various molecular mechanisms could contribute to gut frailty, and the decrease in mucus secretion is an extremely early-stage pathology. Dysbiosis of gut microbiota has a major impact on many conditions associated with gut frailty. Prebiotics, probiotics, post-biotics, and fecal microbiota transplantation are under investigation as a treatment option for gut frailty. Key Message: Although the concept of gut frailty has not yet gained widespread recognition, we hope to propose more practical screening methods, diagnostic approaches, and specific interventions in the future.

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Exercise-acclimated microbiota improves skeletal muscle metabolism via circulating bile acid deconjugation

Cited by 11 publications

References 69 publications

Acetate Alleviates Gut Microbiota Depletion-Induced Retardation of Skeletal Muscle Growth and Development in Young Mice

Acetate Alleviates Gut Microbiota Depletion-Induced Retardation of Skeletal Muscle Growth and Development in Young Mice

Regulating bile acids signaling for NAFLD: molecular insights and novel therapeutic interventions

Gut Frailty: Its Concept and Pathogenesis

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