Exenterative pelvic surgery

López, Marvin J.; Spratt, John S.

doi:10.1002/(sici)1096-9098(199910)72:2<102::aid-jso12>3.0.co;2-1

Cited by 26 publications

(15 citation statements)

References 53 publications

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“…Patients with cervical cancer may present at diagnosis with distant metastases (stage IVB) or have, after primary treatment, pelvic recurrence, distant metastases, or a combination of both. Recurrence rates vary from up to 20% to 70% in early stages and locally advanced disease, respectively [ 10 , 11 ] and the majority of recurrences occur within 2 years of diagnosis. At this stage, cervical cancer is even more difficult to treat because this clinical situation is the result of a more malignant phenotype resulting from accumulation of genetic defects during tumor progression and previous therapies; thus, the tumor at this stage is commonly resistant to chemotherapy.…”

Section: Overview Of Cervical Cancermentioning

confidence: 99%

Epigenetics of cervical cancer. An overview and therapeutic perspectives

et al. 2005

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Cervical cancer remains one of the greatest killers of women worldwide. It is difficult to foresee a dramatic increase in cure rate even with the most optimal combination of cytotoxic drugs, surgery, and radiation; therefore, testing of molecular targeted therapies against this malignancy is highly desirable. A number of epigenetic alterations occur during all stages of cervical carcinogenesis in both human papillomavirus and host cellular genomes, which include global DNA hypomethylation, hypermetylation of key tumor suppressor genes, and histone modifications. The reversible nature of epigenetic changes constitutes a target for transcriptional therapies, namely DNA methylation and histone deacetylase inhibitors. To date, studies in patients with cervical cancer have demonstrated the feasibility of reactivating the expression of hypermethylated and silenced tumor suppressor genes as well as the hyperacetylating and inhibitory effect upon histone deacetylase activity in tumor tissues after treatment with demethylating and histone deacetylase inhibitors. In addition, detection of epigenetic changes in cytological smears, serum DNA, and peripheral blood are of potential interest for development of novel biomolecular markers for early detection, prediction of response, and prognosis.

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Section: Overview Of Cervical Cancermentioning

confidence: 99%

Epigenetics of cervical cancer. An overview and therapeutic perspectives

et al. 2005

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“…Ten to fifteen per cent of patients with rectal cancer have a locally advanced tumour on presentation [1,2]. In the last 15 years improved surgery and neoadjuvant treatment have rendered many of these amenable to curative resection [3].…”

Section: Introductionmentioning

confidence: 99%

Health‐related quality of life after surgery for primary advanced rectal cancer and recurrent rectal cancer: a review

2012

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“…These patients subsequently require urinary and fecal diversions; this is usually achieved with an ileal conduit in the right iliac fossa and a separate colostomy in the left iliac fossa [1]. These two stomas result in the inherent difficulties of managing both collection devices besides being expensive and cosmetically depressing.…”

Section: Introductionmentioning

confidence: 99%

Revisiting the double-barreled wet colostomy for simultaneous urinary and fecal diversion—an Indian experience

Sukumar

Sivanandam

Bhat

et al. 2010

Indian J Gastroenterol

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Pelvic exenteration in advanced malignancies is usually a curative procedure aimed at improving quality of life. We analyzed the perioperative data and outcomes in 12 patients who underwent simultaneous urinary and fecal diversion with a double-barreled wet colostomy after total pelvic exenteration. Eight males and four females aged between 25 and 73 years underwent the procedure with mean operative duration of 350 min and mean postoperative stay of 15 days. Three patients developed early complications while four developed late complications. During follow up ranging from 6 to 64 months, four patients died of disease progression while four died of unrelated causes. One lady was lost to follow up, the remaining had a mean survival of 32.9 months. None had deterioration in renal function or peristomal dermatitis and all were well accustomed to managing one stoma. Our results show that double-barreled wet colostomy is technically simple and reduces surgical morbidity while providing satisfactory outcomes and patient comfort.

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Exenterative pelvic surgery

Cited by 26 publications

References 53 publications

Epigenetics of cervical cancer. An overview and therapeutic perspectives

Epigenetics of cervical cancer. An overview and therapeutic perspectives

Health‐related quality of life after surgery for primary advanced rectal cancer and recurrent rectal cancer: a review

Revisiting the double-barreled wet colostomy for simultaneous urinary and fecal diversion—an Indian experience

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