Exendin-4 Promotes Schwann Cell Proliferation and Migration via Activating the Jak-STAT Pathway after Peripheral Nerve Injury

Pan, Bin; Huo, Tianqun; Hu, Youzhong; Cao, Menghan; Bu, Xiangbo; Li, Ziang; Li, Jing; Luo, Xuanxiang; Xiao, Guohong; Hu, Feng; Yuan, Feng; Guo, Kaijin

doi:10.1016/j.neuroscience.2020.04.017

Cited by 10 publications

(5 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ex-4 enhanced the movement of IFRS1 cells toward the neurites and upregulated the protein expression of peripheral myelin protein 22 (PMP22) and myelin protein zero (MPZ). The existence of GLP-1R in both DRG neurons and IFRS1 Schwann cells was confirmed by knock-out validated anti-GLP-1R antibody ( Takaku et al, 2021 ), and Ex-4 promoted neurite outgrowth of DRG neurons ( Himeno et al, 2011 ; Tsukamoto et al, 2015 ) and survival/proliferation and migration of Schwann cells ( Pan et al, 2020 ; Takaku et al, 2021 ). These findings suggest that Ex-4 stimulates GLP-1R in both DRG neurons and Schwann cells to promote myelination.…”

Section: Glp-1ras As Favorable Factors For Myelin Formation and Maint...mentioning

confidence: 92%

“…To our knowledge, this is the first study to introduce GLP-1RAs as oligodendrocyte-protective molecules. Because the expression of GLP-1R in myelin-forming oligodendrocytes has been implicated ( Smith et al, 2022 ) and the stimulatory effects of GLP-1RAs on Schwann cells and OECs have been delineated ( Pan et al, 2020 ; Takaku et al, 2021 ; Tseng et al, 2021 ), it seems plausible that the agents can directly act on oligodendrocytes and their progenitor cells to promote remyelination under MS conditions.…”

Section: Potential Efficacy Of Glp-1ras Toward Demyelinating Disordersmentioning

confidence: 99%

See 1 more Smart Citation

Glucagon-Like Peptide-1 Receptor Agonists as Potential Myelination-Inducible and Anti-Demyelinating Remedies

Sango

Takaku

Tsukamoto

et al. 2022

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) were developed as insulinotropic and anti-hyperglycemic agents for the treatment of type 2 diabetes, but their neurotrophic and neuroprotective activities have been receiving increasing attention. Myelin plays a key role in the functional maintenance of the central and peripheral nervous systems, and recent in vivo and in vitro studies have shed light on the beneficial effects of GLP-1RAs on the formation and protection of myelin. In this article, we describe the potential efficacy of GLP-1RAs for the induction of axonal regeneration and remyelination following nerve lesions and the prevention and alleviation of demyelinating disorders, particularly multiple sclerosis.

show abstract

Section: Glp-1ras As Favorable Factors For Myelin Formation and Maint...mentioning

confidence: 92%

Section: Potential Efficacy Of Glp-1ras Toward Demyelinating Disordersmentioning

confidence: 99%

Glucagon-Like Peptide-1 Receptor Agonists as Potential Myelination-Inducible and Anti-Demyelinating Remedies

Sango

Takaku

Tsukamoto

et al. 2022

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

“…Peripheral nerve injury (PNI) is a common clinical problem that results in substantial disability worldwide [ 1 ]. Statistics show that the incidence of PNI ranges from 1.3 to 2.3 per 100,000 people in developed countries, and this incidence may be higher in developing countries [ 2 ]. The function of the peripheral nervous system can recover to some extent after PNI, and the extent depends on the severity of the injury and the method of treatment; thus, it is different from the central nervous system [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Schwann Cell Pyroptosis Promotes Nerve Regeneration in Peripheral Nerve Injury in Rats

Wang

Yuan

et al. 2023

Mediators of Inflammation

View full text Add to dashboard Cite

Background. Peripheral nerve injury (PNI) is one of the most debilitating injuries, but therapies for PNI are still far from satisfactory. Pyroptosis, a recently identified form of cell death, has been demonstrated to participate in different diseases. However, the role of pyroptosis of Schwann cells in PNI remains unclear. Methods. We established a rat PNI model, and western blotting, transmission electron microscopy, and immunofluorescence staining were used to confirm pyroptosis of Schwann cells in PNI in vivo. In vitro, pyroptosis of Schwann cells was induced by lipopolysaccharides (LPS)+adenosine triphosphate disodium (ATP). An irreversible inhibitor of pyroptosis, acetyl (Ac)-Tyr-Val-Ala-Asp-chloromethyl ketone (Ac-YVAD-cmk), was used to attenuate Schwann cell pyroptosis. Moreover, the influence of pyroptotic Schwann cells on the function of dorsal root ganglion neurons (DRGns) was analyzed by a coculture system. Finally, the rat PNI model was intraperitoneally treated with Ac-YVAD-cmk to observe the effect of pyroptosis on nerve regeneration and motor function. Results. Schwann cell pyroptosis was notably observed in the injured sciatic nerve. LPS+ATP treatment effectively induced Schwann cell pyroptosis, which was largely attenuated by Ac-YVAD-cmk. Additionally, pyroptotic Schwann cells inhibited the function of DRGns by secreting inflammatory factors. A decrease in pyroptosis in Schwann cells promoted regeneration of the sciatic nerve and recovery of motor function in rats. Conclusion. Given the role of Schwann cell pyroptosis in PNI progression, inhibition of Schwann cell pyroptosis might be a potential therapeutic strategy for PNI in the future.

show abstract

“…Peripheral nerve injury caused by trauma is a very common clinical disease (1) and the main repair method is direct end-toend repair by suturing the epineurium (2). However, complete recovery of nerve function is rarely achieved.…”

Section: Introductionmentioning

confidence: 99%

Electrospun Polycaprolactone (PCL)-Amnion Nanofibrous Membrane Promotes Nerve Regeneration and Prevents Fibrosis in a Rat Sciatic Nerve Transection Model

et al. 2022

View full text Add to dashboard Cite

Functional recovery after peripheral nerve injury repair is typically unsatisfactory. An anastomotically poor microenvironment and scarring at the repair site are important factors impeding nerve regeneration. In this study, an electrospun poly-e-caprolactone (PCL)-amnion nanofibrous membrane comprising an amnion membrane and nonwoven electrospun PCL was used to wrap the sciatic nerve repair site in the rat model of a sciatic nerve transection. The effect of the PCL-amnion nanofibrous membrane on improving nerve regeneration and preventing scarring at the repair site was evaluated by expression of the inflammatory cytokine, sciatic functional index (SFI), electrophysiology, and histological analyses. Four weeks after repair, the degree of nerve adhesion, collagen deposition, and intraneural macrophage invasion of the PCL-amnion nanofibrous membrane group were significantly decreased compared with those of the Control group. Moreover, the PCL-amnion nanofibrous membrane decreased the expression of pro-inflammatory cytokines such as interleukin(IL)-6, Tumor Necrosis Factor(TNF)-a and the number of pro-inflammatory M1 macrophages, and increased the expression of anti-inflammatory cytokine such as IL-10, IL-13 and anti-inflammatory M2 macrophages. At 16 weeks, the PCL-amnion nanofibrous membrane improved functional recovery, including promoting nerve Schwann cell proliferation, axon regeneration, and reducing the time of muscle denervation. In summary, the PCL-amnion nanofibrous membrane effectively improved nerve regeneration and prevent fibrosis after nerve repair, which has good clinical application prospect for tissue repair.

show abstract

Exendin-4 Promotes Schwann Cell Proliferation and Migration via Activating the Jak-STAT Pathway after Peripheral Nerve Injury

Cited by 10 publications

References 27 publications

Glucagon-Like Peptide-1 Receptor Agonists as Potential Myelination-Inducible and Anti-Demyelinating Remedies

Glucagon-Like Peptide-1 Receptor Agonists as Potential Myelination-Inducible and Anti-Demyelinating Remedies

Inhibition of Schwann Cell Pyroptosis Promotes Nerve Regeneration in Peripheral Nerve Injury in Rats

Electrospun Polycaprolactone (PCL)-Amnion Nanofibrous Membrane Promotes Nerve Regeneration and Prevents Fibrosis in a Rat Sciatic Nerve Transection Model

Contact Info

Product

Resources

About