Exemplifying Natural (R)-β-Transamination Potential of Fold Type-IV Transaminase for Kinetic Resolution of rac-β-Amino Acids Synthesized from Aldehydes
Amol D. Pagar,
Taresh P. Khobragade,
Pritam Giri
et al.
Abstract:Sustainable synthesis of chiral β-amino acids from renewable feedstocks is of significant importance. The Rodionov reaction is a popular method to synthesize rac-β-amino acids from aldehydes, which are abundant byproducts of biomass. rac-β-Amino acids are easily converted into the enantiopure (R)-form by kinetic resolution using (S)-β-transaminases (TAs). However, the inaccessibility of natural (R)-β-transaminases with a broader substrate scope limits the application of the Rodionov reaction to produce (S)-β-a… Show more
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